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National Health and Medical Research Council Act - National Health and Medical Research Council - Report - 1993


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1 9 9 3 ANNUAL REPORT

of the

National Health and

Medical Research Council

National Health and Medical Research Council

NHMRC

1 9 9 3 ANNUAL

REPORT

o f t h e

N a t i o n a l H e a l t h a n d

M e d i c a l R e s e a r c h

C o u n c i l

National Health and Medical Research Council

N H M R C

© Commonwealth of Australia 1994

ISSN 1322 - 929 X

This work is copyright. It may be reproduced in whole or in part for study or training purposes subject to the inclusion of an acknowledgement of the source and no commercial usage or sale. Reproduction for purposes other than those indicated above, require the written permission of the Australian Government Publishing Service, GPO Box 84, Canberra

ACT 2601.

The objective of the National Health and Medical Research Council is to advise the Australian community on the achievement and maintenance of the highest practicable standards of individual and public health and to foster research in the interests of improving those standards.

Enquiries about the content of this report should be directed to:

Mr J.P. Corcoran Executive Secretary National Health and Medical Research Council GPO Box 9848 CANBERRA ACT 2601

Telephone (06) 289 7019 Fax: (06) 289 7802

The H on Dr C Lawrence

M inister for H um an Services andH ealth

Parliam ent H ouse

Canberra ACT 2600

Dear Minister

In accordance with Section 83 of the National Health and Medical Research Council Act 1992,1 present the Annual Report of the National Health and Medical Research Council for 1993.

Subsection 83(3) of the above Act requires you to lay the Report before each House of the Parliament within 15 sitting days of receiving it.

Yours sincerely

R Smallwood

Chairm an of Council

2 9 AUS 1991 *

-

C ontents

Introduction...................................................................................................................... 1

Ministerial pow ers......................................................................................................1

Functions, composition and membership of Council............................................... 1

Functions............................................................................................................... 1

Composition and m em bership..........................................................................

Committee structure of the Council.........................................................................

Organisation chart for National Health and Medical Research Council...... Functions of Council Committees............................................................................

Executive Committee of Council.........................................................................

Australian Health Ethics Committee..................................................................

Health Care Committee......................................................................................

Medical Research Committee............................................................................

Public Health Committee.....................................................................................

Public Health Research and Development Committee....................................

Composition and membership of Council Committees........................................

Staff, consultants and work arrangements.............................................................

Council............................................................................................................................

Review of the National Health and Medical Research Council.............................. 1

Terms of reference.................................................................................................. 1

Conclusions............................................................................................................. 1

Proposals................................................................................................................ 1

Health and medical research program ..................................................................... 1

Research strategy................................................................................................... 1

Achievements of 1993 .......................................................................................... 1

Training aw ards................................................................................................ 1

Career structure................................................................................................1

Public health focus........................................................................................... 1

Aboriginal health..............................................................................................1

Mental h e a lth ................................................................................................... 1

National Rural Health Unit...............................................................................1

Research units................................................................................................... 1

Research institutes and centres....................................................................... 1

Project g ra n ts ................................................................................................... 1

Program grants................................................................................................. 1

Development program grants..........................................................................1

Small g ra n ts..................................................................................................... 1

Research funding statistics.............................................................................. 16

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Health care program .................................................................................................... 17

Achievements during 1 9 9 3 .................................................................................... 17

Standards for the provision of health c a r e .....................................................17

Guidelines for clinical practice........................................................................ 17

Guidelines for preventive health care.............................................................. 18

Better management of chronic conditions....................................................... 19

Improving the health of older persons............................................................. 19

Health technology assessment..........................................................................19

Public health program ..................................................................................................20

Communicable diseases........................................................................................ 20

Social issues............................................................................................................21

Population health issues............................................. 21

Radiation health ..................................................................................................... 21

Chemical safety...................................................................................................... 22

Environmental influences....................................................................................... 22

Food and health..................................................................................................... 22

Australian Health Ethics Committee........................................................................... 23

Support of I EC system ............................................................................................23

Ethics of resource allocation................................................................................. 23

APPENDIXES I Composition and membership of Executive Committee and Principal Committees........................................................................................ 25

Executive Committee....................................................................................25

Australian Health Ethics Committee.......................................................... 25

Health Care Committee.............................................................................. 27

Medical Research Committee..................................................................... 28

Public Health Committee.............................................................................30

Public Health Research and Development Committee..............................31

II Regulatory and interim regulatory recommendations made by Council in 1 9 9 3 .................................................................................................32

III Guidelines issued by Council in 1993 ............................................................... 33

IV A summary of grants expenditure for 1 993 ......................................................34

V Summary of Medical Research Committee grants for 1 9 9 4 ........................... 42

VI A summary of Public Health Research and Development grants for 1994 . 249 VII List of publications issued by Council 1 9 9 3 .....................................................263

VII Media releases issued by Council 1993 ........................................................ 264

IX Annual report of the NHMRC Commissioner of Complaints.......................... 265 X Inquiries by Parliamentary Committees........................................................... 266

XI Comments by the Om budsm an........................................................................267

XII Decisions of Courts and Administrative Tribunals......................................... 268

XIII Freedom of Information.....................................................................................269

XIV Privacy................................................................................................................ 270

XV Environmental and Energy Issues.................................................................... 271

XVI Acronyms used in this re p o rt........................................................................... 273

Introduction

The N ational H ealth and Medical Research Council was established in 1936 and it operated in accordance with an O rder in Council prior to 24 June 1993 when it became a statutory body authorised by the National H ealth and Medical Research Council Act 1992.

The objective of the Council is to advise the Australian community on the achievement and maintenance of the highest practicable standards of individual and public health and to foster research in the interests of improving those standards.

This is the first Annual Report of the Council and relates to the calendar year 1993.

M inisterial p o w e rs The Council is responsible to the M inister for H um an Services and Health. Subsection 9(1) of the Act provides that the Minister m ay refer to the Council any m atter within the scope of its functions while subsection 10(1) authorises the

M inister to give written directions to the Council as to the performance of its functions or the exercise of its powers. No such reference or direction was given during 1993.

Functions, com position a n d m em b ersh ip of Council Functions

The functions of the Council are as follows.

1. To inquire into, issue guidelines on, and advise the community on, matters relating to:

• the im provem ent of health;

• the prevention, diagnosis and treatment of disease;

• the provision of health care;

• public health research and medical research; and

• ethical issues relating to health.

2. To advise, and make recom m endations to, the Commonwealth, the States and Territories on the m atters referred to in paragraph 1.

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3. To m ake recommendations to the Com m onwealth on expenditure:

• on public health research and training; and

• on medical research and training;

including recommendations on the application of the Medical Research Endow m ent Fund.

4. Any functions incidental to any of the foregoing.

Com position an d m em bership

The composition and mem bership of the Council at 31 December 1993 was

Chairperson Dr D.G. H orvath

Secretary to the Council Dr J. Loy

Chairperson of each of the principal committees:

H ealth Care Committee, Professor R.A. Smallwood

Australian Health Ethics Committee, Ms R. Layton QC Medical Research Committee, Professor D.I. McCloskey Public Health Committee, and Dr A. Adam s

Public H ealth Research and Professor K. Donald

Development Committee

One nom inee from each State Dr P.S. Morey NSW

and Territory health Dr C. Brook VIC

instrum entality nom inated by the Dr D. Lange QLD

the appropriate Minister Dr K. Kirke SA

Dr A. Penm an WA

Dr J. Sparrow TAS

Dr M.V. Dunjey NT

Dr C. Mead ACT

An officer of the Department Dr A. Adam s

of H um an Services and Health nom inated by the Minister for Health

A person nom inated by the Ms N. M ayers

Aboriginal and Torres Strait Islander Commission, and having knowledge of the health needs of Aboriginal persons or Torres Strait Islanders

A person w ith expertise in Professor G.B. Ryan

health care training

A person with knowledge of Professor S.E. Dorsch professional medical standards and expertise in post-graduate medical training

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A person w ith a background in, and knowledge of, the medical profession

A person w ith a background in, and knowledge of, the nursing profession

An em inent scientist who has knowledge of public health research and medical research issues, and who has no current connection w ith the Council

A person w ith a background in, and knowledge of, the trade union m ovem ent

Dr B. Nelson

A /Professor R. Pratt

Professor P.I. Komer

Ms P. Staunton

A person w ith a background in, Ms M. Jackson and knowledge of, business

A person w ith a background in, Ms J.D. G raham and knowledge of, consumer needs

A person w ith knowledge of Mrs J. Roberts

the needs of users of social welfare services

A person w ith knowledge of Ms A.E.G. Reeves

environm ental issues

Three other persons with Professor M. Neave

expertise relevant to the Professor M. Charlesworth

functions of Council Professor S. Encel

The National Health and Medical Research Council Act provides for the composition of the Council to be varied through the inclusion of a person with background in, and knowledge of, public health issues and the reduction, from three to two, of the maximum num ber of members in the category of persons with

expertise relevant to the functions of the Council. The Act provided for those persons who were members of the Council as at 24 June 1993 to continue to be members until 31 December 1993. A ppointm ents to the Council for the triennium 1994 to 1996 have been m ade in accordance with this varied composition.

Com m ittee structure of th e Council During 1993 the NHMRC carried out its functions with the assistance of an executive committee, five principal committees and a range of standing committees, w orking parties and expert panels.

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O rg an isatio n chart for N ational H ealth a n d Medical Research Council Council Principal Com m ittees Standing Com m ittees Executive —

A ustralian H ealth Institutional Ethics Committees Ethics Ethics of Resource Allocation

H ealth Care Australian Health

Technology Advisory Committee Child Health Dental Health Mental Health Quality of Health Care W omen's Health

M edical Research Animal Welfare

Career Awards Grants Grants and Awards Access NHMRC Institutes and Units Advisory Committees * Research Strategy

Training Awards

Public H ealth Communicable Diseases

Drugs and Poisons Environmental Health Food and Health Public Health Awards Radiation Health

Toxicity

Public H ealth Research

Research and * Research Strategy

D evelopm ent Training Awards

Working Party on the Development of an NHMRC

Women's Health Strategy and Implementation Plan

Working Party on NHMRC interaction in respect of National Health Goals and Targets

------------------------------------ Communications Committee

------------------------------------ Publications Committee

* Joint Standing Committee

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Functions of Council Com m ittees The functions of the Executive Committee and the Principal Committees were as follows.

Executive Com m ittee of Council

1. To act on behalf of the Council as its executive organ.

2. To keep under regular consideration the work of the Council and its Principal Com m ittees and to ensure implem entation of their decisions.

3. To advise the Council on the organisation of the work of the Council and its Principal Committees.

4. To perform any other function that the Council may, from time to time, . determine.

NB Functions shown from 24 June 1993 as provided in National Health and Medical Research Council Act 1992.

A ustralian H ealth Ethics Com m ittee 1. To advise the Council on ethical issues relating to health.

2. To develop and give the Council guidelines for the conduct of medical research involving hum ans.

3. To develop and give the Council guidelines for ethical conduct in the health field, addtional to those require for function (2) and for the purposes of the Privacy Act 1988.

4. To prom ote community debate, and consult w ith individuals, community organisations, health professions and governm ents on health ethical issues.

5. To m onitor, and advise on, the workings of institutional ethics committees.

6. To m onitor international developm ents in relation to health ethical issues and liaise with relevant international organisations.

Health C are Com m ittee 1. To inquire into, and advise the Council on, m atters relating to health care and the provision of health services.

2. To inquire into, and advise the Council on, the merits of methods of disease prevention, diagnosis and treatment.

3. To receive, and make recom mendations to the Council in relation to:

• reports of expert groups and specialist working parties; and

• representations from community groups.

4. To prepare reports, submissions and any other documents relating to the functions of the committee for distribution by the Council.

5. To advise the Council on means of providing information to the Australian com m unity on m atters relating to the functions of the committee.

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M edical Research Com m ittee 1. To advise and make recom mendations to the Council on the application of the Medical Research Endow m ent Fund.

2. To m onitor the use of assistance provided from that Fund.

3. To advise the Council on matters relating to medical research, including the quality and scope of such research in Australia.

4. Other such functions as the Minister for Health from time to time determines.

NB Functions from 24 June 1993 as provided in National Health and Medical Research Council Act 1992.

Public Health Committee

1. To inquire into, and advise the Council on, m atters of public health, preventive medicine and the im provem ent of health, including environm ental health, and the health of Aboriginal and other ethnic groups.

2. To advise the Council on the legislation and administrative procedures that should be introduced by the Commonwealth, the States or the Territories to implem ent the m atters referred to in paragraph 1.

3. To receive, and make recommendations to the Council on, reports of expert groups and working parties in m atters relating to the Com m ittee's functions.

4. To prepare reports, submissions and any other documents relating to the functions of PHC for distribution by the Council.

5. To advise the Council on means of providing information to the Australian comm unity on m atters relating to the functions of the Committee.

Public Health Research a n d D evelopm ent Committee

1 · To develop guidelines for the funding of research in the field of public health.

2. To advise the Council on recommendations to be made by the Council to the Commonwealth in respect of research in the field of public health.

3. To advise and make recommendations to the Council on the allocation of funds for the conduct and promotion of research in the field of public health.

4. To advise the Council on means of providing information to the Australian comm unity on matters relating to the functions of the committee.

Com position a n d m em bership of Council Com m ittees The compositions and m emberships of the Executive Committee and the Principal Committees are shown in Appendix 1.

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Staff, co n su ltan ts a n d w o rk a rra n g e m e n ts The secretariat support for the Council and its committees is provided by staff of the D epartm ent of H um an Services and Health. To enhance the efficiency and

expertise of these staff in assisting the Council and the Department in their respective activities, the activities of supporting the Council are integrated into the functions of the Departm ent. The other resources utilised by the Council are also provided by the Departm ent and are not separately identified.

This arrangem ent is authorised by the Act which provides that the Council may make arrangem ents with the Secretary to the Departm ent of Hum an Services and Health for

• the services of officers or em ployees of the D epartm ent employed under the Public Service Act 1992 to be m ade available to the Council (subsection 45(2));

• persons having suitable qualifications or experience to be engaged as consultants to the Council (subsection 46(1)); and

• the provision of facilities to the Council that are necessary for the Council to perform its functions or to exercise its powers under the Act (subsection 47).

These resource m atters are therefore embraced w ithin the reports of the Departm ent of H um an Services and Health. However, it is estimated that the costs to the D epartm ent resourcing the NHMRC in 1992-93 w ould have been approxim ately $7 million including $2.2 million for salaries and $2.2 million for committee support. A broad range of on costs account for the remaining estimated expenditure of $2.6 million covering such expenditure items as superannuation, accom modation, information technology and other corporate support.

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Council

The M embers of the Council are part-time and are appointed for a period of up to three years. Consequently the work of Council is planned and reviewed on a triennial basis.

The Council usually meets in full session twice each year, in June and November, and publishes a report of the proceedings of each session. It undertakes its work through a network of Principal Committees, working committees and expert panels. The members of the network are part-tim e and give much of their time and expertise without remuneration.

In accordance with the National Health and Medical Research Council Act 1992 the Council prepared a strategic plan for the period June 1993 to June 1994 and undertook a review of its implementation of that Plan. The resultant publications entitled 'Strategic Plan June 1993-30 June 1994' and 'Revie.w of Implementation of Strategic Plan June 1993-June 1994' were tabled in both Houses of the Commonwealth Parliament.

The major issues addressed in the strategy were:

• inequalities in health status including the developm ent of a NHMRC Women's Health Strategy and Implementation Plan;

• improving understanding of chronic conditions;

• ageing;

• environmental health;

• national health goals and targets; and

• research.

These and further priorities were pursued through the Council's four programs

• health and medical research:

• public health;

• health care; and

• ethics.

These programs are reported upon later in this report.

The regulatory recommendations made by the Council and the guidelines issued by it in 1993 are listed in Appendices II and III respectively.

The Council places emphasis on undertaking its functions with the assistance of appropriate consultation. Committees, working committees and expert panels are constituted to ensure that relevant professional and community interests are

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represented. In form ulating guidelines, standards and advice the Council consults as widely as practicable and appropriate.

It is im portant that the advice of Council is widely disseminated and so significant effort is devoted to a publications program. The publications released during 1993 are listed at A ppendix VII

Media releases issued during the year are listed at Appendix XIII.

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Review of the National Health and Medical Research Council

On 8 A ugust 1993 the then M inister for Health, Senator the Hon G. Richardson, announced that there w ould be a review of the NHMRC to be conducted by Dr John Bienenstock, Dean and Vice-President, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.

Terms of reference The term s of reference of the review were to

' · examine the effectiveness of the NHMRC and its Principal Committees in carrying out the Council's function of advising Governments and the com m unity on health issues;

• examine the procedures adopted by the Council and its committees, including the processes for assessing proposals for funding of health and medical research through the NHMRC;

• report on the effectiveness of Australian health and medical research in meeting current and developing national health priorities. In particular the review should examine alternative mechanisms explicitly to direct research funding to identified priority areas; and

• make recommendations on the overall structure of the Council and its Principal Committees and on granting procedures for health and medical research.'

Conclusions

The review reported in December 1993. It concluded that:

...the NHMRC is an organisation of fundam ental importance to Australia. Most of the concerns that have been expressed about it, that it is a tool of governm ents or the medical profession, or that the research program is a 'club' that does not work in the national interest, are misplaced.'

'...Nevertheless ... the NHMRC has yet to develop a process which enables it to operate as a coherent and coordinated whole. ...In addition, at present the NHMRC does not have within itself the capacity to set its own priorities and strategies on a comprehensive and coordinated basis, or to m onitor its activities

in an ongoing and independent fashion.'

Another major conclusion of the report was that there is a need for data to be gathered to enable priority areas in health to be identified so that bodies such as the NHMRC can direct their efforts to those areas.

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P roposals The review proposed that

'available health information in Australia and overseas should be marshalled together and presented in a way that enables organisations such as the NHMRC to develop rational health plans and policies. The NHMRC should in addition have a structure in place — to be know n as the Strategic Health and Research

Planning (SHARP) Committee — that can analyse such information, recom m end priorities, strategies and plans, and m onitor their implementation.'

'...In im plem enting research priorities, strategies and plans ... the NHMRC needs to balance a continued high level of support for basic investigator-driven research with mechanisms for developing research in areas that are not sufficiently well supported through the general competitive scheme.'

'The review also recommends that the NHMRC move tow ards a m ultidisciplinary and interprofessional approach to health advice and research. Specific recom m endations are m ade to merge the Public Health Committee and the H ealth Care Committee, while retaining their special expertise and focus as

necessary, and to promote broader approaches in the funding and support of health research.'

'...more resources are urgently needed for the NHMRC. These resources are needed both for infrastructure support for the NHMRC, and also for the research funding program.'

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Health and medical research program

R esearch stra te g y The NHMRC Research Strategy 1993-95, was first presented to Government in 1992 and was re-presented in 1993.

The Research Strategy was specifically aligned with Council's overall Strategy, and proposed means for meeting the research needs of all elements of that overall strategy. Amongst the proposals in the Research Strategy were the establishment of special units on Aboriginal and Torres Strait Islander Health Research, Ageing Research, and Women's Health Research. Major program shifts to provide larger aggregates of research activity in some areas of high merit, and to assist the commercialisation of promising research results, were also proposed, together with enhancem ent to research training and retraining.

Overall, the Research Strategy identified enhancem ent of the qualities of excellence and relevance in health and medical research as goals for the decade ahead, and advocated increasing the nation's investment in medical and health research through the forthcoming decade from its (then) current level of 1.5% of total health

expenditure to a level more in keeping with the minimum of 2% recommended by the International Commission on Health Research for Development.

In a pre-election statement in March 1993, Prime Minister Keating reported the Governm ent's strong record of support for medical and health research, and noted that, the results, in terms of research which improves the health of all Australians, have been outstanding.’ He referred to the NHMRC Research Strategy, and undertook ’to work with medical researchers and the business sector to lift research funding to 2% of total health expenditure by the Year 2000’.

Upon assum ing the Health portfolio after the election, the Minister for Health commissioned an external review of the NHMRC with wide-ranging terms of reference, and an emphasis on research needs, capabilities and funding mechanisms. The reviewer, the eminent Canadian academic, researcher and adm inistrator, Dr John Bienenstock, from McMaster University, Ontario, Canada

visited Australia on two separate occasions in conducting his review. The Medical Research Committee (MRC) made every effort to see that he obtained the information he sought. The MRC has welcomed the Report by Dr Bienenstock, which is in general a most positive and constructively critical document, containing im portant recommendations for the developm ent of Australian health and medical research.

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Throughout 1993, further examination was m ade of difficulties in medical research funding that had been experienced during 1992. With the assistance of consultants from the private sector, various indexation factors were identified that had contributed to the previous difficulties. With the agreem ent and co-operation of the

Departm ent of H um an Services and Health and the Departm ent of Finance, these were rectified w ith the result that the funding position was somewhat improved.

The round of medical research grant applications processed during 1993 for award in 1994 resulted in a success rate of 27%, and no nett loss of grants in total, and a success rate of 20 % for PHRDC grants. Furthermore, major initiatives were begun in Aboriginal and Torres Strait Islander Health Research and in establishing a Netw ork of Brain Research in Mental Health. Nevertheless, the MRC continued to

find it necessary to apply 'contingency cuts' of approxim ately 15% to the budgets recom mended for all grants. Recommended budgets are themselves 15% less than requested budgets.

Despite difficulties, it is w orth noting that medical research remains an area of acknowledged national strength.

The PHRDC and MRC are conscious that this research sector must go beyond just high achievem ent in scientific endeavour. Health and medical research underpins national health and provides a pool of experts who share in, and then optimally translate the w orld's research into professional practice and education in the

service of all Australians.

A chievem ents of 1993 The health and m edical research program is m anaged jointly by the PHRDC and the MRC. These comm ittees develop guidelines for the funding of medical and public health research and advise the Australian Government, through Council, on

recom m endations for the allocation of funds to conduct and promote research.

Training a w a rd s

The Minister approved, on the advice of MRC, 334 MRC training awards, including 152 medical and dental scholarships, 56 Dora Lush (biomedical) scholarships, 58 CJ Martin Fellowships, 23 Neil Ham ilton Fairley Fellowships and 27 Australian Postdoctoral Fellowships. Two fellowships were aw arded with the assistance of

funds from the National Action Plan for Dementia Care and Soroptomist International.

Strong interest w as again show n in PHRDC training awards in 1993. The Committee was able to offer 12 new Fellowships and 12 new Scholarships which when combined w ith the continuing aw ards gives 49 awards which PHRDC will fund in 1994.

C areer structure The MRC provides a continuum of career support for outstanding researchers, from scholarship training through to the most senior levels of research. In 1994, the MRC recommended the aw ard of 16 new Research Fellowships, together with 26

promotions and reappointm ents of existing Fellows.

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A total of 48 RD Wright aw ards will be supported in 1994, with 15 new aw ards offered. These provide support for highly talented new researchers. One of these aw ards was supported with funds from the National Action Plan for Dementia Care.

PHRDC has agreed to develop a career structure within the training awards program which will be titled Principal/ Senior Research Fellowship and this will replace the Post Training Fellowship Award. The Fellowships are designed for people with an outstanding record of achievement in public health research as an independent researcher, and who wish to pursue careers in public health.

Public health focus Public health research is supported through both the MRC and the PHRDC. For 1994, over $12 million has been allocated to such research, $6.5 million through PHRDC.

At its meeting in October 1993, the Committee agreed that granting decisions should be guided by 6 priority topics, 7 priority groups and 4 priority strategies.

The priority topics are prevention of cardiovascular disease, prevention of injury, cancer, mental ill-health, nutrition in relation to health and public health aspects of environmental deterioration. The priority groups are Aborigines, people with disability, recent migrants, elderly people, women, adolescents and unemployed youth. The priority strategies are multi-disciplinary approaches, interventions rather than descriptive studies, improvement in equity of health outcomes and participation by people experiencing the health issues in the research.

A boriginal health

The joint PHRDC/M RC Aboriginal Health Working Party recom mendation that five grants be funded was approved. Grants were approved for periods of between one and three years. The Working Party will commence reviewing the success of the grants towards the end of 1994 when the first report is expected.

PHRDC and MRC have agreed to provide a further $250,000 each to fund a new round of Aboriginal Health Research Grants. It is an im portant initiative that the Aboriginal communities are responsible for the administration of these grants and

that in each case the community is represented on the grant in the conduct of the research.

M ental health

The MRC was able to direct additional resources to mental health research with the assistance of funding provided through the National Action Plan for Dementia Care, which enabled the support of additional research fellowships and an RD Wright award, and with additional funds provided in the 1992-93 Budget.

The MRC has used these funds in 1993 to establish a Network of Brain Research in Mental Health. The aims of the Network are to develop and coordinate m ulti­ disciplinary research into the nature and treatm ent of neuropsychiatric disorders. The Network will receive $0.5m each year for five years. The MRC will examine options for allocating the remaining Mental Health funds in 1994.

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The funds com plem ent the vigorous activity in research in this area that is being supported through the NHMRC. They bring the total support for mental health research, neuroscience, and psychiatry to over $21.5 million.

N ational Rural H ealth Unit

The establishm ent of a National Rural Health Unit was one of the recom m endations of the National Rural Health Strategy endorsed in principle by Australian H ealth Ministers.

PHRDC on behalf of AHMAC sought applications from organisations to establish and operate a National Rural Health Unit. Eight applications were received and the Rural Health Unit Working Party interviewed the two highest ranked groups. The Working Party's recom mendation was forwarded to AHMAC and the successful group has been recom mended to the Minister.

Research units

The MRC will support six research units in priority areas in 1994, at a total cost of $3.1 million. These are the Road Accident Research Unit (reviewed in 1993), a Mental Health Research Network, the Environmental Toxicology Research Unit, the Social Psychiatry Research Unit, the Schizophrenia Research Unit, and the Clinical

Trials Unit.

PHRDC supports one major research unit. This is the National Centre for Health Program Evaluation, located at Fairfield Hospital, M elbourne. Total PHRDC funding for the Centre was $335,00 which was virtually m atched by the Victorian Health Promotion Fund. It will be reviewed in April 1994.

Research institutes an d centres The MRC supports five major medical research institutes and centres with block grant funding. These are the Walter and Eliza Hall Institute, the Howard Florey

Institute, the Baker Institute, the Murdoch Institute for Research into Birth Defects, and the Garvan Institute. Total funding for these institutes was $18.1 million.

Project g ra n ts In 1993, the MRC received 1297 applications for funding support. Nearly 80% of applicants were interviewed, and the final allocations for 1994 comprised 322 com peting project grants. The success rate was 27%. The total allocated to project grants, including projects which continued from previous years, was $56.4 million.

The num ber of applications to PHRDC for project grants increased from 125 last year to 147 this year. The final allocations for 1994 comprised 29 new grants and continuations for 24 existing grants. The success rate for new grants was 20% and the total allocated to new and continuing grants was $2.47million.

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P rogram g ra n ts The MRC provides five year funding for larger groups of researchers which can provide an im portant focus for research activity. In 1994 the MRC recom mended $11.1 million for the support of 21 program grants. Two existing program s were reviewed in 1993 and one was recom mended to revert to project grants after the end of 1994.

D evelopm ent program g ra n ts

PHRDC provides three to five year funding to experienced researchers for population based public health research that is expected to have im m inent practical benefits to the Australian public. Thirteen applications were received this year and two have been approved for funding in 1994. There are four continuing grants and

the total allocated to new and continuing grants was $1.32million.

The broad research topics covered by these grants are workplace health promotion, prevention of cataract, prevention of skin cancer, prevention of cancer in rural communities, prevention of coronary heart disease, and dietary interventions and bone mass.

Small g ra n ts PHRDC Small grants were advertised twice this year to encourage the groups wishing to do public health research in a shorter timeframe and also to enable the basic research to be completed before applying for a project grant. These grants are also to encourage people who have not received a grant before to see if the type of research they are planning is viable. In the first round 62 applications were received and 12 of these are to be funded. In the second round 107 applications have been received and 11 are recommended for funding. The total allocated for Small grants in 1994 is $0.4million.

Research funding statistics Appendices IV to VI provide information on the research funding approved for the calendar years 1993 and 1994.

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Health care program

The Council's health care program is m anaged by the Health Care Committee (HCC). The role of the HCC is to advise the Council on m atters relating to health care and the provision of health services, including m ethods of disease prevention, diagnosis and treatment.

A chievem ents during 1993 The following is a summ ary of the Health Care Com m ittee's m ain activities during the year against the themes established in the strategic plan.

S ta n d a rd s for the provision of health care The M aternal M ortality Working Party reported on m aternal deaths for the 1988-90 period, based on an analysis of data provided by State M aternal Mortality Committees. The report found an increasing and unacceptably high rate of

m aternal deaths among Aboriginal women, with a high proportion of avoidable deaths. As a result, the Women's Health Committee has commenced discussions with representatives of the Aboriginal community on the establishment of a working party to address Aboriginal maternal health issues.

A report on options for effective care of women in childbirth was prepared by an expert panel of the Women's Health Committee. The report indicates a need to review the culture of obstetric care in Australia and recom mends that women should be informed early in their pregnancy of the options for maternity care

available to them. The public will be invited to comment on this report before it is finalised.

The Child Health Committee produced a report on perinatal morbidity which recommends action to be taken at the levels of policy and planning as well as clinical practice to reduce m orbidity from pre-term birth, perinatal asphyxia, intra­ uterine growth restriction, perinatal infection and congenital malformations.

G uidelines for clinical practice A recent, innovative initiative has been the establishment of the Standing Committee on Quality of Health Care (QHC). This committee's role is to develop a national approach to and m ethodology for the development of clinical practice guidelines which focus on im proving patient health outcomes. It will work with the clinical colleges and other expert groups to facilitate and encourage the developm ent of such guidelines and outcome measures.

17

The QHC has produced a draft methodology for developing clinical practice guidelines and established guideline developm ent dem onstration projects for the procedural and surgical m anagem ent of coronary heart disease and the treatment of diagnosed breast cancer.

Another major project during the triennium was the developm ent of general guidelines for medical practitioners on providing information to patients. The main purpose of these guidelines is to foster better communication betw een doctor and patient, so that patients can be assisted to make the best decisions about their medical care. The guidelines are being widely distributed to medical practitioners, medical schools, consumer organisations and the general public.

Guidelines have been developed for the m anagem ent of women w ith cervical abnorm alities detected in cancer screening.

The long term effects on women from assisted conception are being assessed, including the adequacy of both information provided to women and of follow-up.

Public consultation will be undertaken on revised guidelines for the donation of organs and tissues.

The educational material currently available on schizophrenia for health professionals, patients, families and the general public is being assessed by a working party of the Mental Health Committee. The working party has identified im portant gaps which it will address by developing new material suitable for different target groups.

G uidelines for preventive health care A review of the effectiveness of child and adolescent screening program s was completed. This review is part of a larger review of preventive health care activities, which is also examining prenatal, neonatal and adult programs.

A Working Party on Suicide Prevention was convened to produce a policy statem ent on suicide. The policy statement will outline ways of recognising at risk behaviour and provide guidelines to help prevent suicide. The Working Party will

also review existing m ethods for the collection of data on suicide in Australia.

The Mental Health Committee reported on the scope for prevention in the mental health field. This is a comprehensive scientific review of preventive strategies and draw s together the available evidence for the effective prevention of m ental ill health. W hen endorsing the report, Council suggested it should provide the starting point for further initiatives and agreed to the Mental Health Committee undertaking further work in target areas such as violence, abuse, youth mental health and depression.

The relationship between folic acid in m aternal diet and the prevention of neural tube defects in infants was addressed, with the HCC's previous statement being revised and updated in the light of new findings.

Interim recommendations on the adm inistration of vitamin K to prevent haemorrhagic disease of the newborn were produced following a report from the United Kingdom which suggested that the intram uscular route might be associated w ith a twofold increase in childhood cancer.

18

These recom m endations are now being reviewed in light of further overseas reports. Guidelines for health care workers and inform ation for parents will be produced.

Better m a n a g e m e n t of chronic conditions The expert panel on diabetes produced a statement on the relationship between diabetes and exercise.

A report on hom e mechanical ventilation for children defined the role of this treatm ent and established which individuals should be eligible for it. This report considered a range of legal, social and ethical issues in the m anagem ent of children w ith respiratory failure as well as making recom m endations about the organisation

and funding of services for such children.

An expert panel of the Child Health Committee is examining ways of improving the m anagem ent of chronic illness and disability in adolescence.

Im proving the health of o ld er persons The expert panel on the health of older persons produced reports relating to clinical m anagem ent problems, including incontinence, falls, musculoskeletal difficulties,

the value of exercise and minimising the effects of hospitalisation. Further reports on chronic pain and polypharm acy are being written. These reports are largely directed to health professionals.

In addition, the Dental Health Committee produced a report on oral health care for older adults and the Mental Health Committee reported on the diagnosis and m anagem ent of mental disorders in older persons.

H ealth technology asse ssm e n t In 1992, the Australian Health Technology Advisory Committee (AHTAC) became a standing committee of Health Care Committee. AHTAC is developing its role as the central co-ordinating body for health technology assessm ent in Australia.

During the year, AHTAC has m ade recommendations on applications for nationally funded centre status for bone m arrow transplantation, heart transplantation and liver transplantation. Other work completed included a report on the treatment of sleep apnoea and a pam phlet giving consumers up-to-date information on the

safety and effectiveness of the new technology of laser corneal sculpting.

AHTAC working parties have been established to address several areas of health technology, including microwave therapy of the prostate, beam and isotope radiotherapy, and health service guidelines for acute cardiac interventions.

19

Public health program

The public health program covers those aspects of NHMRC activities w ith a population-w ide focus, and is m anaged by the Public Health Committee.

PHC develops policies, guidelines and standards to protect the health of the com m unity from hazards in the environment. In m any instances these activities augm ent those of the HCC and specific health problems are dealt w ith by both committees working together.

PHC also provides the mechanism to prom ote uniform legislation throughout Australia in m atters affecting public health concerns including air, water and soil quality, communicable diseases, food and nutrition, dm g and poison scheduling and radiation health.

The following is a sum m ary of the PHC's m ain activities during 1993 against the them es established in the NHMRC Strategic Plan.

C om m unicable d iseases At the request of the Australian Health M inisters' Advisory Council (AHMAC), the Communicable Disease Standing Committee developed a National Immunisation

Strategy to address inadequacies in childhood imm unisation arrangem ents in Australia. The strategy was endorsed in principle by AHMAC and it was agreed to establish a Com m onw ealth/State working group to further develop an im plem entation plan.

A 'Strategic Framework for Tuberculosis Control in Australia' was a major project undertaken by the Communicable Diseases Standing Committee. The docum ent outlines the nature of the current tuberculosis problem in Australia, stresses the continued importance of planned tuberculosis control in the Australian community, and provides a framework for a course of action to maintain Australia's position as

having one of the lowest rates of tuberculosis in the world.

A recent initiative has been the establishment of an expert panel to m onitor tuberculosis in Australia. This panel is to advise the Communicable Diseases Standing Committee on the control of tuberculosis, and to prepare and distribute updated information on this disease. The first task for the panel will be to develop detailed guidelines and protocols recom mended in the strategic framework.

An information pam phlet for parents on Haemophilus influenzae type b (Hib) disease and immunisation was produced by another expert panel of the Communicable Diseases Standing Committee. Sponsorship has been obtained for the printing of the pam phlet and it is proposed to have the document translated into four com m unity languages.

20

The Panel on M alaria produced new guidelines for prophylaxis against malaria. The use of 'M aloprim ' has been phased out and a greater reliance placed on the use of doxycycline and mefloquine. The new recom mendations are considered safer and sim pler than previous recommendations, and bring Australia more in line with

the World Health Organization recommendations.

The joint N H M R C / AHMAC Task Force on Hepatitis C produced a report and recom mendations on the epidemiology, natural history and control of hepatitis C. The Task Force is currently examining the evidence on the use of interferon as a treatm ent for hepatitis C.

Other activities in the area of communicable diseases undertaken during 1993 include the preparation of detailed guidance for the prevention of infectious diseases in child care settings, and the development of surveillance case definitions for the purpose of m onitoring diseases in Australia. A w arning to travellers,

medical practitioners and pathology laboratories about the risks from a new strain of cholera w as issued. The NHMRC also drew attention to precautions that travellers should take to avoid infection.

Social issues A report on boxing injuries of the brain, eye, cervical spine and other parts of the body was produced by an expert panel. The report updates a 1986 NHMRC publication, and indicates new directions for those concerned with public health

and legislation related to boxing.

A similar investigation into head and neck injuries resulting from participation in football (all codes) is underway.

P opulation health issues A joint PH C /H C C Working Party on Asthma was established in late 1993 to review national and international statistical information on asthm a and report on changes

which have occurred in Australia in asthm a m orbidity and mortality. The Working Party is to review current asthm a m anagement procedures and recommend future strategies and action which can improve compliance w ith optimal asthma m anagem ent procedures.

R adiation health The Radiation Health Standing Committee continued with its three main programs of:

• updating existing NHMRC advice related to radiation health and drafting new standards;

• developing A ustralia's new radiation protection standards jointly with Worksafe Australia and in line with international practice; and

• taking steps tow ards achieving national uniformity of radiation control legislation and practices.

21

D uring 1993, increased attention was given to the latter program and a special three day workshop, attended by State and Territory radiation control officers, was held in Adelaide. Arising from the workshop, a report containing a num ber of recom mendations for achieving more uniform ity w as prepared for submission to

AHMAC.

Chem ical sa fe ly A scientific review of the toxicity of dioxins was produced by the Standing Committee on Toxicity. The data indicated that the levels typical in most food and environm ental exposures are unlikely to pose any appreciable public health risk. On the basis of this review, NHMRC has agreed to consider setting a tolerable daily intake and will seek public comment on the proposal before final consideration.

The Standard for the uniform scheduling of drugs and poisons (SUSDP) No. 8 was issued in late 1993, and the Drugs and Poisons Schedule Standing Committee further developed recommendations for the harm onisation between Australia and New Zealand of packaging and labelling of poisons and pharmaceuticals.

The cessation of NHMRC involvement w ith the setting of m aximum residue limits in foods and animal feedstuffs and the disbanding of the Pesticides and Agricultural Chemicals Standing Committee occurred in early 1993. The responsibility has been transferred to the Chemicals Safety Unit of the Department of H um an Services and Health.

Environm ental influences The prim ary focus of the Environmental Health Standing Committee has been the revision of the Australian guidelines for lead in blood and the timeframe for achieving the goal for all Australians to have blood lead concentrations below ten

micrograms per decilitre.

Other areas of activity for the Environmental Health Standing Committee has been the continued revision of the Australian Drinking Water Guidelines, the developm ent of air quality goals for nitrogen dioxide and sulphur dioxide, the preparation of a report outlining principles for ecology and health, and an assessment of the implications of risk and economic factors in environmental health management.

Food a n d h ealth Many of the Food and Health Standing C om m ittee's activities are long-term and involve extensive public comment. One activity of major importance is the preparation of a discussion paper on the core food groups, which will provide the basis for the developm ent of future nutrition education tools.

Other activities include the development of dietary guidelines for children to com plem ent the existing NHMRC dietary guidelines for Australians, and the preparation of guidelines for health workers to promote and support breastfeeding.

22

A ustralian Health Ethics Committee

The work of AHEC has been directed to the promotion of ethical research through support of the system of institutional ethics committees and the fostering of consideration of the ethics of resource allocation in health.

S u p p o rt of IEC system Clarification of AHEC's role has occurred particularly in relation to its task of providing institutional ethics committees (IECs) w ith information, guidance and support. In May 1993, AHEC conducted a survey of IECs to gather information on

the establishm ent and current operation of IECs. This was followed by a series of w orkshops in July and August. While principally for mem bers of IECs, an opportunity was also provided for researchers and consumers to contribute their views on the workings of IECs and AHEC. These two major activities were of

considerable im portance in the clarification of AHEC's role in the IEC system, and in the identification of priority areas for attention by AHEC in the coming year.

The clear, general view expressed was that although there will always be some aspects on which guidelines will be necessary, AHEC's role should be to give guidance as to w hat is ethically relevant, allowing IECs to make their own decisions. M any IECs are looking to AHEC to operate as a reservoir of information

on which they can call, as well as a central point from which relevant information can be dissem inated.

AHEC places considerable importance on effective communication to facilitate its work. The IEC workshops and survey were components of a strategy to strengthen links with IECs and researchers. Communication is also undertaken through the ’Australian Health Ethics Committee Newsletter’ which is published twice a year,

and through TEC N ew s’, specifically intended for IECs. The first issue of ’IEC New s’ was published in April and the second in December 1993. Contributions to this newsletter are welcomed m aking it a vehicle for IECs to communicate with each other as well as with AHEC. Correspondence and phone contact are, of

course, also im portant and regularly used for communicating information on AHEC's activities, and seeking comment.

Ethics of resource allocation Two significant papers issued by AHEC were

• a discussion paper on the legal liability, insurance and indem nity arrangements for IECs; and

• an information paper on hum an gene therapy and related procedures.

23

The ethics of resource allocation, which is fundam ental to the equitable provision of health care, has been an area of focus for AHEC during 1993. Activities have included preparation of a case study using the example of screening blood donors for HTLV-I to explore the ethical and legal ramifications of the decision-making

process and preparation of a brief discussion paper exploring ethical considerations relating to health care resource allocation decisions.

The ethics of health resource allocation is an aspect which is inherent in the consideration of the ethics of any health care, research or public health matter. As such this aspect will continue to be a fundam ental part of AHEC's work, but not as a major focus. AHEC believes it can provide a valuable function in relation to health care and public health similar to that which it provides in the promotion of ethical research. That is, it can disseminate information and provide guidance on

what is ethically relevant to help providers of health care and public health services make ethical decisions. AHEC will be looking to develop this role in 1994.

24

APPENDIX I — Com position a n d m em bership of Executive Committee an d Principal Committees

Executive Com m ittee

Com position a n d m em bership Chairperson of Council

Chairperson of the Health Care

Dr D. Horvath

Committee Professor R.A. Smallwood

Chairperson of the Australian

Health Ethics Committee

Chairperson of the Medical

Ms R. Layton QC

Research Committee

Chairperson of the Public

Professor D.I. McCloskey

Health Committee Dr A. Adams

Chairperson of the Public Health

Research and Development

Committee

Two other m em bers of Council

Professor K. Donald

Mrs J. Roberts

Dr D. K Kirke

A ustralian H ealth Ethics Committee

Com position a n d m em bership Chairperson

A person w ith a knowledge of the ethics of medical research

Ms R. Layton QC

Professor R. Kalucy

A person who has expertise in law

A person who has expertise in philosophy

Professor D. Chalmers

Professor M. Charlesworth

A person w ho has expertise in religion Sister R. Dunne RSM

A person w ho has experience in medical research Professor J. Funder

A person who has experience in public health research Dr H. Mitchell

A person who has experience in social science research Dr S. Gifford

25

A person who has experience in clinical medical practice Professor A. Woolcock

A person who has experience in nursing or allied health practice Ms R. Watts

A person with knowledge of the regulation of the medical profession

Dr R. Simpson

A person with understanding of health issues of concern to consumers

Ms H. Bastian

Member in common with HCC Ms H. Bastian

Member in common with MRC Sister R. Dunne RSM

Member in common with PHC Dr S. Gifford

Member in common with PHRDC Dr H. Mitchell

26

H ealth C are Com m ittee Composition and membership

Chairperson Professor R.A. Smallwood

Two NHMRC m em bers nom inated Dr J. Sparrow by the Australian H ealth M r P. Read

M inisters' A dvisory Council

Six nominees from the Specialist Medical Colleges

Australian College of Paediatrics

Royal A ustralasian College of Surgeons

Royal Australian College of General Practitioners

Professor A. Carmichael

Professor R.C. Bennett

Dr J. Gambrill

Royal Australian and New Zealand College of Psychiatrists

Royal Australian College of Obstetricians and Gynaecologists

The Royal College of Pathologists of Australasia

One of three nom inees from the Australian Medical Association

One of three nominees from the Australian Dental Association

Professor B. Raphael

Professor C. Michael

Professor H.K. Muller

Dr B. Walpole

Dr R.G. Woods

One of three nominees from the Royal College of Nursing, Australia

One of three nom inees from the Australian Federation of Consum er Organisations

One of three nominees from the Australian Hospital Association

One of four nom inees from para­ medical professional associations

One of three nom inees of the Pharmaceutical Society of Australia

Chairm an of the Australian Health Technology Advisory Committee

Miss J.L. Meppem

Ms H. Bastian

M r). Tribe

Professor L.T. Twomey

Mr J. Bell

Dr B. Kearney

One nom inee of the Com m onwealth Ms D. Ariotti Departm ent of H um an Services and Health

27

Three persons appointed on the advice of HCC Chairman, being persons with expertise respectively in

• health economics

• epidemiology

• comm unity health

M ember in common w ith AHEC

M ember in common with MRC

M ember in common w ith PHC

M ember in common with PHRDC

Secretary to the Council

Ms H. Lapsley

Professor F. Stanley

Ms J. Dwyer

Ms H. Bastian

Professor L.T. Twomey

Mr J. Bell

Ms D. Ariotti

Dr J. Loy

M edical R esearch Committee Composition and membership

Chairperson

One of three nominees of the Com m ittee of Deans of Australian and New Zealand Dental Schools, being citizens or perm anent

residents of Australia engaged in research

One person from among persons nom inating themselves as interested in appointm ent, being persons engaged in research in health sciences other than medicine and dentistry

Two nominees from a list composed of three nominees from the Australian Federation of Consum er Organisations and

three from the Australian Council of Social Service

Eleven persons experienced in medical research appointed on the advice of the Chairm an of MRC after the Chairman has consulted with the Dean of each medical school at an Australian University and with the Australian Society for

Professor D.I. McCloskey

Professor P. Reade ·

Professor L.T.Twomey

Dr R. Walker(AFCO) Mr A.E. Clarke (ACOSS)

Dr J. Angus Professor C. Burrell Professor M. Clark Dr A. Green Professor E. McLachlan) Professor G. Tregear) Professor T.J. Martin Professor S. Pond

28

Medical Research Professor N. Saunders

Dr R. Scollay Professor R. Sutherland Professor J. W hitworth

Member in com m on with HCC Professor L.T. Twomey

M ember in com m on w ith AHEC Sister R. Dunne RSM

M ember in com m on with PHC A /Professor I. Calder

M ember in com m on with PHRDC Professor K. O'Dea

Secretary to the Council Dr J. Loy

Co-opted members:

Dr W. Anderson, Baker Medical Research Institute

Professor P.J. McDonald, Flinders Medical Centre

Dr J.G. McDougall, H ow ard Florey Institute

Professor J. McLeod, University of Sydney

Mr J. Plunkett, Industry Research and Development Board

29

Public H ealth Com m ittee C om position and m em bership

Chairperson

One nom inee w ith expertise in public health from each of the Com m onwealth Departm ent of H um an Services and Health, and State, NT and ACT health authorities (9 in all)

One of three nominees of the National Occupational Health and Safety Commission

One of three nominees of the Confederation of Australian Industry

One of three nominees of the Australian Council of Trade Unions

One of three nominees of the Australian Federation of Consum er Organisations

One epidem iologist from three epidem iologists nom inated by the Public Health Association of Australia

A person with knowledge and expertise relevant to environmental health A person with experience and

knowledge of behavioural research

A person with knowledge of public health issues affecting Aboriginal people

M ember in common with HCC

M ember in common with AHEC

M ember in common w ith MRC

M ember in common with PHRDC

Secretary to the Council

Dr A. Adams

Dr A.L. Black CWTH

Dr G. Frost NSW

Dr G.J. Rouch VIC

Dr G. M urphy QLD

A /Prof. I. Calder SA

Dr A. Penman WA

Dr M. Jacobs TAS

Dr P. Wilson NT

Dr C. Mead ACT

Dr E.A. Emmett

Mr H. Boulton

A /Professor G. Duggin

Dr V. Brown

Professor R. Douglas

Professor A. McMichael

Professor C. Ewan

Ms M. Baldwin-Jones

Mr J. Bell

Dr S. Gifford

A /Professor I. Calder

Professor J. McNeil

Dr J. Loy

30

Public H ealth R esearch a n d D evelopm ent Com m ittee Com position and m em bership

Chairperson Professor K. Donald

Nom inee of the Com m onwealth D epartm ent of H um an Services and Health

Ms D. Ariotti

An NHMRC m em ber nom inated by the A ustralian Health M inisters' Advisory Council

Dr P.S. Morey

One nom inee of the Australian Institute of H ealth and Welfare Dr J. Donovan

One of three nom inees of the Public H ealth Association of Australia

Ms P. Hawe

One of three nom inees of the Australian Com m unity Health Association

Ms L. King

One of three nom inees of the Consum ers' H ealth Forum of Australia

Dr S. Short

One of three nom inees of the Australian Council of Social Service M sG. Walker

Six persons appointed on the advice of the Chairm an of PHRDC, being persons w ith expertise in one or more of the following

fields:

• epidemiology • health economics and statistics • hum an behaviour in relation to disease

• public health adm inistration • research in health services • social analysis

Professor J. Reid M r S. Nangala Professor J. M athews Dr H. Mitchell Professor M. Liveris

Dr P. Saunders

Member in common with HCC Ms D. Ariotti

Member of AHEC Dr H. Mitchell

M ember in common with MRC Professor K. O'Dea

M ember in common with PHC Professor J. McNeil

Secretary to the Council Dr J. Loy

31

APPENDIX II — R egulatory an d interim reg u lato ry recom m endations m a d e by Council in 1993 Standard for the uniform scheduling of drugs and poisons No. 8.

Standard for the uniform scheduling of drugs and poisons No. 8, Am endm ent No. 1.

Boxing injuries.

32

APPENDIX III — G uidelines issued by Council in 1993 A ustralian Guidelines for lead in blood and lead in ambient air

General Guidelines for m edical practitioners on providing inform ation to patients

Screening to prevent cervical cancer: guidelines for the m anagement of women w ith screen detected abnormalities.

33

APPENDIX IV — A su m m a ry of g ra n ts e x p e n d itu re for 1993

GRANTS NSW VIC QLD SA WA TAS ACT NT

Project 273 267 123 121 62 7 12 1

$17,105,799 $17,681,571 $8,017,789 $7,969,145 $4,730,716 $419,058 $884,309 $80,299 Equipment 8 13 4 6 1 1

$208,671 $438,550 $132,807 $117,031 $44,773 $9,800

Special 19 12 4 9 1 1 4 2

Initiatives $887,122 $487,682 $208,256 $395,899 $39,244 $45,780 $207,725 $170,069

Priming 17 10 9 7 2

$624,711 $356,250 $333,443 $259,568 $61,095

Bridging 3 1 1 2 1

Support $166,839 $61,019 $37,262 $107,078 $39,410

Special 1 4 2

Investigation $99,966 $223,442 $81,586

Programs 2 9 2 2 5

$1,125,093 $4,200,008 $1,009,307 $1,331,571 $1,882,366 Research 1 1 1 1 1

Units $498,331 $338,259 $538,905 $493,059 $669,933

Research 1 1

Centres $2,081,625 $1,135,477 •

Research 3

Institutes $14,530,981

Training 99 139 29 34 14 2 5 1

Awards $2,644,575 $4,195,605 $721,038 $971,721 $381,318 $95,870 $161,840 $15,974

New 10 18 6 5 6

Investigator $597,861 $1,095,621 $366,179 $315,812 $351,486

TOTAL 434 478 179 189 92 11 22 4

$26,040,599 $44,744,465 $11,364,988 $12,042,474 $7,530,411 $570,509 $1,923,809 $266,343

National Total

866

$56,888,689 33 $951,634 52 $2,441,782

45

$1,635,068 8 $411,610 7 $404,996

20

$9,548,346 5 $2,538,489 2

$3,217,103 3 $14,530,981 323

$9,187,945 45 $2,726,960

1409

$104,483,605

S u m m a ry o f P roject G rants fo r 1993 — b y State, b y in s titu tio n

C om peting grants

Grants

In s titu tio n s — N ew South Wales

Centenary Institute Children's Medical Research Foundation Cum berland College of Health Sciences H unter Area Health Service Eastern Sydney Area Health Service Garvan Institute of Medical Research

H eart Research Institute Institute of Dental Research John H unter Hospital Macquarie University

M ater Misericordiae Hospital Red Cross Blood Transfusion Service Prince Henry & Wales Hospital Royal Alexandra Hospital for Children Royal North Shore Hospital Rozelle Hospital Royal Prince Alfred Hospital SENSW & ACT Hydatid Control St Vincent's Hospital

University of New England University of Newcastle University of N.S.W. University of Sydney

University of Wollongong University of Western Sydney, Nepean Westmead Hospital

TOTAL NEW SOUTH WALES

Cont. grants

$ s u p p o rt No. No.

supported a p p li­

cations

No. supp­ orted as %

o f total

Total

$ support No.

supp­

orted

41840.26 1 2

83843.03 2 7

0.00 0 0

0.00 0 2

0.00 0 0

0.00 0 1

259837.93 3 5

98072.66 2 9

0.00 0 4

126580.10 3 11

75447.61 1 1

0.00 0 3

46236.50 1 2

0.00 0 4

46262.16 1 21

35960.06 1 1

268849.94 6 21

48736.48 1 1

0.00 0 12

0.00 0 1

591283.62 10 40

1863577.86 26 99

1802361.83 34 154

45838.66 1 8

0.00 0 0

396287.22 6 19

5831015.92 99 428

50.00 42802.58 1

28.57 400897.26 6

0.00 41470.55 1

0.00 51242.23 1

0.00 40816.53 1

0.00 121295.42 1

60.00 251458.19 5

22.22 93492.48 2

0.00 46885.46 1

27.27 200012.12 4

100.00 42312.04 1

0.00 9808.08 1

50.00 106086.82 2

0.00 38120.66 1

4.76 366554.17 8

100.00 0.00 0

28.57 927792.49 14

100.00 0.00 0

0.00 206630.66 5

0.00 35052.95 1

25.00 1352882.23 21

26.26 3145389.07 51

22.07 5104195.23 80

12.50 100771.92 2

0.00 47028.12 1

31.57 489098.42 11

23.13 13262095.68 222

$ to ta l Total

No.

84642.84 2

484740.29 8 41470.55 1

51242.23 1

40816.53 1

121295.42 1 511296.12 8 191565.14 4 46885.46 1

326592.22 7 117759.65 2 9808.08 1

152323.32 3 38120.66 1

412816.33 9 35960.06 1

1196642.43 20 48736.48 1

206630.66 5 35052.95 1

1944165.85 31 5008966.93 77 6906557.06 114 146610.58 3

47028.12 1

885385.64 17 19093111.60 321

C om peting grants Cont. grants Total

$ s u p p o rt No. supp- No. No. supp- $ support

orted a p p li- orted as %

Grants cations o f total

V ictoria Austin Hospital 0.00 0 6 0.00 95618.02

Alfred Hospital 26435.74 1 7 14.28 0.00

Austin Research Institute 9800.00 1 2 50.00 57366.54

La Trobe University College of N th Vic 0.00 0 1 0.00 34132.80

Baker Medical Research Institute 29400.00 1 1 100.00 99097.00

Peter MacCallum Cancer Institute 133748.47 3 18 16.66 142316.86

Deakin University 0.00 0 7 0.00 150375.93

Fairfield Hospital 0.00 0 2 0.00 40677.13

Howard Florey Institute 58800.00 1 1 100.00 41003.89

ω International Diabetes Institute 0.00 0 1 0.00 78524.34

O· La Trobe University 231458.58 5 19 26.31 601989.43

Ludwig Institute for Cancer Research 82100.50 2 4 50.00 358953.10

Macfarlane Burnet Centre 0.00 0 6 0.00 47915.53

Mental Health Research Institute 90097.30 1 3 33.33 111898.28

M urdoch Institute 12250.10 1 2 50.00 0.00

Monash University 1512195.37 27 112 24.10 3871168.29

National Gerontology Institute 37662.33 1 1 100.00 0.00

National Vision Research Institute 0.00 0 2 0.00 115008.99

Prince H enry's Institute 655920.56 7 13 53.84 1121842.49

Royal Children's Hospital Research Fd 0.00 0 12 0.00 610149.17

Royal Melbourne Hospital 91710.90 2 12 16.66 49200.77

Royal Women's Hospital 80028.57 2 3 66.66 0.00

St Vincent's Hospital 233281.09 4 8 50.00 177014.32

St Vincent's Institute 148252.90 3 4 75.00 453720.90

University of Melbourne 2559940.07 36 141 25.53 4858870.40

Victorian College of Pharmacy 0.00 0 6 0.00 50389.54

Walter & Eliza Hall Institute 88200.00 1 1 100.00 0.00

TOTAL VICTORIA 6081282.48 99 395 25.06 13167233.72

No. $ total Total

supp- No.

orted

1 95618.02 1

0 26435.74 1

1 67166.54 2

1 34132.80 1

2 128497.00 3

3 276065.33 6

4 150375.93 4

1 40677.13 1

1 99803.89 2

1 78524.34 1

10 833448.01 15

7 441053.60 9

1 47915.53 1

1 201995.58 2

0 12250.10 1

62 5383363.66 89

0 37662.33 1

3 115008.99 3

14 1777763.05 21

11 610149.17 11

1 140911.67 3

0 80028.57 2

4 410295.41 8

4 601973.80 7

74 7418810.47 110

1 50389.54 1

0 88200.00 1

208 19248516.20 307

Competing grants Total

Grants

Queensland Griffith University James Cook University of Nth Qld Queensland Institute of Medical

Queensland University of Technology Royal Brisbane Hospital Foundation Royal Children's Hospital University of Queensland TOTAL QUEENSLAND

South A u stra lia \ l ACCART Adelaide C hildren's Hospital Adelaide Medical Centre

University of Adelaide Child Health Research Institute The Flinders University of SA Institute of Medical & Veterinary Science

Mclnnes ENERMATION Queen Elizabeth Hospital Royal Adelaide Hospital Dr R.V.Southcott

South Australian Institute of Technology TOTAL SOUTH AUSTRALIA

$ sup p o rt No. supp- No. No. sup;

orted a p p li- orted as

cations o f total

Cent, grants

69734.05 1 8 12.50

45838.66 1 16 6.25

872389.06 14 36 38.88

33843.46 1 29 3.44

95413.27 1 3 33.33

9800.00 1 1 100.00

1827912.15 33 125 26.40

2954930.65 52 218 23.85

0.00 0 0 0.00

19600.00 1 1 100.00

316188.82 5 15 33.33

618671.77 13 40 32.50

0.00 0 0 0.00

1185855.32 16 57 28.07

561198.81 10 26 38.46

53684.40 1 1 100.00

0.00 0 16 0.00

51257.99 1 20 5.00

0.00 0 0 0.00

0.00 0 0 0.00

2806457.11 47 176 26.70

$ support No. $ total Total

supp- No.

orted

243912.52 5 313646.57 6

0.00 0 45838.66 1

842714.37 14 1715103.43 28

73128.18 2 106971.64 3

0.00 0 95413.27 1

401176.12 5 410976.12 6

4213696.28 63 6041608.43 96

5774627.47 89 8729558.12 141

31606.80 1 31606.80 1

0.00 0 19600.00 1

446391.71 7 762580.53 12

1715754.16 29 2334425.93 42

35717.67 1 35717.67 1

2476385.85 36 3662241.17 52

687275.44 10 1248474.25 20

0.00 0 53684.40 1

184832.81 4 184832.81 4

506068.14 10 557326.13 11

6143.52 1 6143.52 1

33677.40 1 33677.40 1

6123853.50 100 8930310.61 147

DISCIPLINE CLASSIFICATION OF NHMRC PROJECT GRANTS 1993

Competing grants D I S C I P L I N E S

Cont. grants Total

$ s u p p o r t N o . N o . N o . s u p p $ s u p p o r t N o .

s u p p - a p p lic - o rte d as % s u p p -

_______________ o r te d a tio n s o f to ta l________________ o rted

$ to ta l

s u p p ­

o rt

010 Anaesthetics & intensive care 0.00 0 9 0.00 103430.57 2

011 Biochemistry &clinical chemistry 1655612.21 28 90 31.11 3361061.32 49

012 Biomedical engineering & biophysics 93926.35 2 15 13.33 142057.36 2

013 Biostatistics 38786.88 1 2 50.00 209863.16 2

014 Cardiovascular diseases & sciences 1159849.01 14 61 22.95 1656819.11 27

015 Community health 48736.48 1 13 7.69 261976.83 4

016 Dentistry & oral surgery 257261.83 6 26 23.07 742441.89 14

017 Dermatology 63311.39 1 4 25.00 86393.47 1

018 Endocrinology 1316688.31 20 77 25.97 2496098.54 35

ω 019 Epidemiology 470175.98 5 25 20.00 700204.02 8

Ό 020 Gastrointestinal diseases & sciences 241304.52 5 16 31.25 1417900.92 27

021 Gerontology & geriatrics 0.00 0 11 0.00 90071.29 1

022 Gynaecology 178257.51 3 21 14.28 372247.10 8

023 Haematology 618332.06 11 42 26.19 1153302.56 19

024 Hepatology 146391.23 3 16 18.75 684455.45 13

025 Immunology 1541103.52 23 91 25.27 3882153.58 63

026 Microbiology, parasitology, virology 1631460.03 27 91 29.67 3332060.18 51

027 Morphology (including embryology) 322966.59 5 13 38.46 150027.87 2

028 Neurological diseases & neurosciences 2151047.17 29 105 27.61 5497093.21 74

029 Nutrition 135824.69 3 19 15.78 93990.99 2

030 Oncology & carcinogenesis 424556.62 8 69 11.59 1967214.23 33

031 Orthopaedics 164715.94 3 14 21.42 277033.99 4

032 Otorhinolaryngology 0.00 0 11 0.00 35052.95 1

033 Paediatrics 84536.27 2 15 13.33 358728.34 8

034 Pathology 73539.40 1 14 7.14 293401.50 4

035 Pharmacology 888781.19 14 62 22.58 2173662.86 32

036 Physiology 1433767.57 24 50 48.00 1587430.92 28

103430.57 5016673.53 235983.71 248650.04 2816668.12

310713.31 999703.72 149704.86 3812786.85 1170380.00 1659205.44

90071.29 550504.61 1771634.62 830846.68 5423257.10 4963520.21

472994.46 7648140.38 229815.68 2391770.85

441749.93 35052.95 443264.61 366940.90 3062444.05

3021198.49

T otal

2 77 4 3 41

5 20 2 55 13 32

1

11 30 16 86

78 7 103 5

41 7 1

10 5 46 52

Com peting grants D I S C I P L I N E S

Cont. grants Total

$ s u p p o r t N o . N o . N o s u p p $ s u p p o r t N o .

s u p p - a p p lic - o rte d as % s u p p -

_______________ o rte d a tio n s o f to ta l_______________ o rted

$ total supp­ ort

037 Psychiatry & psychology 460648.92 8 66 12.12 1773201.55 38

039 Renal diseases &sciences-including urology 247951.02 5 27 18.51 947185.14 16

040 Reproduction 628947.08 9 31 29.03 1582411.28 22

041 Respiratory diseases & sciences 555003.07 9 35 25.71 1486764.16 25

042 Rheumatology 0.00 0 21 0.00 470364.29 9

043 Surgery 456057.28 8 27 29.62 316134.52 7

044 Toxicology 42340.06 1 10 10.00 406595.60 4

045 Vision & ophthalmology 423367.13 5 31 16.12 1063086.46 18

046 Nuclear medicine 65499.43 2 6 33.33 30962.52 1

047 Genetics 803088.91 10 33 30.30 1090159.00 15

^ 048 Public Health 0.00 0 18 0.00 220864.81 5

2233850.47 1195136.16 2211358.36 2041767.23

470364.29 772191.80 448935.66 1486453.59

96461.95 1893247.91 220864.81

T otal

46 21 31 34

9 15 5 23

3 25 5

TOTAL 1SS13835.65 W, Ϊ287 ΣΓ39 42513903.54 074 61337739.19 WO

NB: The above disciplines DO NOT reflect ALL grants supported d u rin g 1993.

S um m ary of PHRDC g ra n ts fo r 1993 New Awards STATE Projects Seeding Grants Fellowships Post Training

Fellowships

NSW 7 357,289 3 28,736 1 56,313 7 150,549

VIC 8 349,369 2 19,369

QLD 1 42,026 1 5,169 3 62,516

SA 2 88,684 2 20,000 1 64,774

WA 2 80,086 1 9,872 1 56,620

TAS ACT NT 3 141,906

Sub Total 1,059,360 83,146 56,313 121,394

Scholarships

1 19,903 6 130,646

2 42,613

406,227

Continuing Awards STATE Projects Development Evaluation Grants Fellowships Post Training Scholarships

_________________________Program Grants__________________________________________Fellowships________________

NSW 5 256,532 2 471,652 1 50,638 4 180,928 4 71,064

VIC 4 221,777 2 416,092 1 19,057 5 228,825 3 62,516

QLD 1 39,050 1 213,636 1 73,801 1 21,061 1 45,296 1 22,710

SA 2 49,024 1 80,471 6 254,972

WA 5 363,427

TAS 1 36,433 1 39,818

ACT NT 1 59,657 1 233,600 1 54,293

Sub Totals 1,025,900 1,344,980 223,967 779,897 45,296 156,290

Other Continuing

1 313,038

2 60,000

393,038

APPENDIX V — S um m ary of M edical R esearch C om m ittee g ra n ts for 1994

GRANTS NSW VIC QLD SA WA TAS A.C.T

Project 268 274 115

$16,647,624 $18,542,324 $7,717,713 Equipment 15 16 5

$351,991 $615,656 $162,500

Special 14 4 6

Initiative $655,125 $139,793 $310,573

Priming 17 3 6

$633,477 $85,262 $226,593

Bridging 3 4

support $160,477 $234,349

Special 2 5

investigatns $150,024 $215,047

Programs 3 8 3

$1,597,470 $4,128,485 $1,544,933 Research 1 2 1

units $525,841 $849,679 $544,833

Research 1 1

centres $2,297,531 $1,087,966

Research 3

institutes $14,552,777

Training 88 148 28

awards $2,383,716 $4,177,252 $781,046

New 11 19 7

Investigator $689,461 $1,175,103 $422,814 Total 423 487 171

104 74 8 13

$6,837,721 $5,254,518 $450,030 $878,229 7 $172,027 7 $293,673

6

$213,251

4

$113,000 4 $180,634

1

$10,400

2

$87,394

3

$100,220 4 5

$2,333,513 $1,895,677 1 1

$457,757 $754,096

45 15 3 4

$1,323,278 $416,613 $76,451 $128,991 6 5

$372,091 $296,549 183 107 12 20

NT National

total

4 860

$214,359 $56,542,521 1 49

$10,000 $1,435,574 2 39

$171,940 $1,839,135 32 $1,158,584 7

$394,826 10 $465,292 23 $11,500,081

6

$3,132,208 2 $3,385,498 3 $14,552,777

2 333

$27,073 $9,314,420 48 $2,956,020 9 Ϊ412

$26,092,739 $45,803.695 $11.711.006 $12.103,533 $8,156,992 $536,882 $1.848.712 $423,374 $106,676,936

S u m m ary of Project G ra n ts for 1 9 9 4 — by S tate, by institution

Competing grants Cont. grants

Institutions $ s u p p o r t No.

s u p p ­

orted

N o .

a p p lic ­

a tio n s

N o . s u p p ­

o rte d a s %

o f to ta l

$ s u p p o r t N o .

s u p p ­

o rte d

Overseas Auckland Hospital 6000.00 1 1 100.00 0.00 0

Total overseas 6000.00 1 1 100.00 0.00 0

N ew South Wales

Centenary Institute 12000.00 1 4 25.00 85573.92 2

Children's Medical Research In 238862.26 4 5 80.00 302717.15 4

Garvan Institute of Medical Res 45000.00 1 1 100.00 0.00 0

Heart Research Institute 311219.95 6 11 54.54 362074.71 5

Institute of Dental Research 45350.43 1 4 25.00 48384.69 1

John Hunter Hospital 29739.44 1 3 33.33 47401.20 1

Macquarie University 56029.39 2 13 15.38 250183.49 5

Mater Misericordiae Hosp 0.00 0 1 0.00 76277.53 1

Prince Henry & Wales Hosp 0.00 0 11 0.00 46745.10 1

Ryl Alexandra Hosp for Childn 0.00 0 5 0.00 38539.99 1

Royal North Shore Hospital 88882.06 2 28 7.14 220384.18 5

Rozelle Hospital 0.00 0 0 0.00 36355.62 1

Royal Prince Alfred Hospital 775453.19 13 22 59.09 509103.44 10

St. Vincent's Hospital 53121.26 2 6 33.33 162084.45 4

University of Newcastle 525806.45 11 42 26.19 1400445.31 21

University of N.S.W. 1459813.20 29 122 23.77 3583694.65 50

University of Sydney 2489905.42 42 143 29.37 4056650.66 66

University of Wollongong 78806.69 3 8 37.50 128803.93 3

Westmead Hospital 293554.07 7 18 38.88 739756.17 13

Total New South Wales 6503543.81 125 447 27.96 12095176.19 194

Total

$ to ta l

S u p p o r t

6000.00 1

6000.00 1

97573.92 3

541579.41 8

45000.00 1

673294.66 11

93735.12 2

77140.64 2

306212.88 7

76277.53 1

46745.10 1

38539.99 1

309266.24 7

36355.62 1

1284556.63 23 215205.71 6

1926251.76 32 5043507.85 79

6546556.08 108 207610.62 6

1033310.24 20 18598720.00 319

T otal

no.

Institutions 5 s u p p o r t

Competing grants N o . N o . N o . su p p -

su p p - a p p lic - o rte d as %

o rte d a lie n s o f to ta l

Cont. grants 5 s u p p o r t N o .

s u p p ­

o rte d

V icto ria Anti-Cancer Council 105312.87 1 1 100.00 0.00 0

Austin Hospital 36172.06 1 9 11.11 96669.82 1

Austin Hospital Medical Research 49822.77 1 1 100.00 0.00 0

Alfred Hospital 0.00 0 3 0.00 26726.54 1

Austin Research Institute 100097.89 2 3 66.66 0.00 0

Baker Medical Research Institute 89082.40 3 3 100.00 0.00 0

Peter MacCallum Cancer Institute 219462.72 4 13 30.76 279102.06 6

Deakin University 126556.14 4 5 80.00 111341.25 3

H ow ard Florey Institute 125167.79 2 2 100.00 0.00 0

La Trobe University 343672.92 6 18 33.33 644653.19 10

Ludwig Institute for Cancer Res 248451.25 4 9 44.44 282209.99 6

Macfarlane Burnet Centre 98869.08 1 7 14.28 48442.60 1

Mental Health Research Inst 9000.00 1 4 25.00 100156.69 1

M urdoch Institute 19000.00 1 1 100.00 0.00 0

M onash University 2061493.31 31 96 32.29 3452174.39 54

N ational Gerontology Institute 0.00 0 1 0.00 38076.61 1

National Vision Research Inst 0.00 0 2 0.00 61640.82 2

Prince H enry's Institute 632624.69 7 15 46.66 338081.70 5

Royal Children's Hospital Res Fd 402523.09 5 22 22.72 249457.71 5

Royal Melbourne Hospital 115310.92 2 7 28.57 92719.71 2

Royal Melbourne Inst of Tech 20000.00 1 4 25.00 0.00 0

Royal Women's Hospital, 0.00 0 2 0.00 80908.88 2

St Vincent's Hospital 41182.80 2 6 33.33 232048.61 4

St. Vincent's Institute 149541.84 3 4 75.00 434445.05 4

Sw inburne University 61281.82 1 4 25.00 0.00 0

University of Melbourne 2916687.17 45 152 29.60 5184264.09 69

Walter & Eliza Hall Institute 108000.00 1 1 100.00 0.00 0

Total V icto ria 8079313.53 129 395 32.65 11753119.71 177

Total

S to ta l T otal

S u p p o r t no.

105312.87 1

132841.88 2

49822.77 1

26726.54 1

100097.89 2

89082.40 3

498564.78 10

237897.39 7

125167.79 2

988326.11 16

530661.24 10

147311.68 2

109156.69 2

19000.00 1

5513667.70 85

38076.61 1

61640.82 2

970706.39 12

651980.80 10

208030.63 4

20000.00 1

80908.88 2

273231.41 6

583986.89 7

61281.82 1

8100951.26 114 108000.00 1

19832433.24 306

Competing grants Cont. grants

Institutions $ s u p p o r t N o .

s u p p ­

o rte d

N o .

a p p lic ­

a tio n s

N o . s u p p ­

o rte d as %

o f to ta l

$ s u p p o r t N o .

s u p p ­

o r te d

Q ueensland Griffith University 52751.35 1 9 11.11 159115.61 3

James Cook Uni of Nth Qld 0.00 0 6 0.00 38258.12 1

Queensland Institute of Medical 1005437.86 17 32 53.12 826595.31 12

Queensland Uni of Technology 132747.69 4 30 13.33 44286.57 1

Royal Brisbane Hospital 46789.77 1 2 50.00 0.00 0

Royal Brisbane Hospital Res Fnd 0.00 0 1 0.00 96462.82 1

Red Cross Blood Transfusion Svce 14154.00 1 1 100.00 0.00 0

Royal C hildren's Hospital 51369.21 2 6 33.33 221749.89 2

University of Queensland 1462689.25 20 97 20.61 4264972.26 66

Total Queensland 2765939.13 46 184 25.00 5651440.58 86

South A u stra lia ACCART 30000.00 1 1 100.00 0.00 0

Adelaide Medical Centre for 319461.03 6 21 28.57 222447.17 4

University of Adelaide 646713.53 12 55 21.81 1375846.39 23

C.S.I.R.O. 0.00 0 0 0.00 20220.00 1

The Flinders University of SA 1092121.96 16 52 30.76 2223394.63 32

Inst of Med and Vet Science 206329.80 5 18 27.77 863377.88 14

Queen Elizabeth Hospital 47695.59 1 6 16.66 0.00 0

Royal Adelaide Hospital 324882.50 7 16 43.75 117668.72 2

Repatriation General Hospital 89471.41 2 4 50.00 0.00 0

University of South Australia 37262.43 1 3 33.33 0.00 0

Total South A u stra lia 2793938.25 51 176 28.97 4822954.79 76

Total

$ to ta l T otal

S u p p o r t no.

211866.96 4

38258.12 1

1832033.17 29

177034.26 5

46789.77 1

96462.82 1

14154.00 1

273119.10 4

5727661.51 86

8417379.71 132

30000.00 1

541908.20 10

2022559.92 35

20220.00 1

3315516.59 48

1069707.68 19

47695.59 1

442551.22 9

89471.41 2

37262.43 1

7616893.04 127

Institutions

Competing grants Cont. grants

S support No. No. No. supp- $ support No.

supp- applic- orted as % supp-

____________ orted ations of total_________________ orted

Total

5 total Total

Support no.

Western A u stra lia Aust N eurom uscular Research Inst 126018.21 2 4 50.00 23583.09 1 149601.30

Curtin University of Technology 6000.00 1 11 9.09 65707.29 2 71707.29

Murdoch University 125831.44 3 11 27.27 38288.44 1 164119.88

Royal Perth Hospital 109856.26 2 21 9.52 42778.73 1 152634.99

Sir Charles G airdner Hospital 221152.03 4 5 80.00 31217.00 1 252369.03

Australian N eurom uscular Inst 43328.43 1 2 50.00 0.00 0 43328.43

University of Western Australia 1844188.43 28 75 37.33 2718849.64 32 4563038.07

WAR1CH 151353.87 3 5 60.00 0.00 0 151353.87

Total Western A u stra lia 2627728.67 44 134 32.83 2920424.19 38 5548152.86

Tasmania University of Tasmania 124138.88 4 24 16.66 336291.12 5 460430.00

Total Tasmania 124138.88 4 24 16.66 336291.12 5 460430.00

A u stra lia n C a p ita l T e rrito ry (ACT)

Australian National University 58405.43 1 3 33.33 543778.44 9 602183.87

University of Canberra 0.00 0 0 0.00 56568.77 1 56568.77

Woden Valley Hospital 32772.44 1 4 25.00 ■ 274099.59 3 306872.03

T O T A L A C T 91177.87 2 7 28.57 874446.80 13 965624.67

N orthern T e rrito ry Menzies School of Health Res 143176.63 4 9 44.44 253123.51 3 396300.14

Total N o rth e rn T errito ry 143176.63 4 9 44.44 253123.51 3 396300.14

3 3 4

3 5 1

60 3 82

9 9

10 1 4 15

7 7

Discipline classification of NHMRC Project G ra n ts 1994

Competing grants Cont. grants

D I S C I P L I N E S $ s u p p o r t N o . N o . N o s u p p $ s u p p o r t

s u p p - a p p lic - o r te d a s %

____________________________________________________________ o rte d a tio n s o f to ta l___________

010 Anaesthetics and intensive care 55884.39 1 6 16.66 0.00

Oil Biochemistry and clinical chemistry 2630869.91 37 98 37.75 3254357.76

012 Biomedical engineering and biophysics 49871.62 1 17 5.88 145979.36

013 Biostatistics 0.00 0 0 0.00 154326.15

014 Cardiovascular diseases and sciences 1117066.20 21 72 29.16 1409509.27

015 Community health 0.00 0 6 0.00 56564.36

016 Dentistry and oral surgery 90366.57 2 19 10.52 753274.90

017 Dermatology 89932.24 1 4 25.00 65502.02

018 Endocrinology 918480.35 13 56 23.21 2250744.69

019 Epidemiology 105312.87 1 14 7.14 748473.64

020 Gastrointestinal diseases and sciences 582761.46 9 32 28.12 1026381.21

021 Gerontology and geriatrics 46400.36 1 11 9.09 0.00

022 Gynaecology 140561.99 2 15 13.33 352441.99

023 Haematology 527326.17 11 37 29.72 1321683.76

024 Hepatology 207196.78 4 10 40.00 543289.79

025 Immunology 2486685.61 36 108 33.33 3120446.70

026 Microbiology, parasitology, virology 1750478.83 29 99 29.29 3122127.74

027 Morphology (including embryology) 146993.40 2 4 50.00 383111.34

028 Neurological diseases and neurosciences 2565238.95 41 124 33.06 5215895.39

029 Nutrition 176527.43 3 9 33.33 199782.03

030 Oncology & carcinogenesis 847712.71 15 72 20.83 1625757.26

031 Orthopaedics 192177.09 3 11 27.27 149012.07

032 Otorhinolaryngology 54813.57 1 7 14.28 143424.23

033 Paediatrics 131950.72 3 22 13.63 392531.93

034 Pathology 348997.29 5 14 35.71 329596.55

Total

N o . $ to ta l T otal

s u p p - s u p p ­

o r te d o rt__________

0 55884.39 1

48 5885227.67 85

2 195850.98 3

2 154326.15 2

21 2526575.47 42

1 56564.36 1

16 843641.47 18

1 155434.26 2

34 3169225.04 47

7 853786.51 8

21 1609142.67 30

0 46400.36 1

7 493003.98 9

21 1849009.93 32

9 750486.57 13

50 5607132.31 86

48 4872606.57 77

6 530104.74 8

65 7781134.34 106

4 376309.46 7

25 2473469.97 40

3 341189.16 6

3 198237.80 4

8 524482.65 11

4 678593.84 9

D I S C I P L I N E S

Competing grants Cont. grants Total

$ s u p p o r t N o . N o . N o s u p p $ s u p p o r t N o .

s u p p - a p p lic - o rte d as % s u p p -

_______________ o rte d a tio n s o f to ta l_______________o rte d

$ to ta l T otal

s u p p ­

o rt

035 Pharmacology 900175.65 13 49 26.53 2072892.91 29

036 Physiology 846206.91 17 45 37.77 2313540.41 36

037 Psychiatry and psychology 1352500.95 25 79 31.64 1177264.65 23

039 Renal diseases and sciences - including ur 379217.53 6 32 18.75 671030.43 11

040 Reproduction 397197.23 7 32 21.87 1068797.34 16

041 Respiratory diseases and sciences 1044105.88 17 40 42.50 1070420.84 18

042 Rheumatology 136168.71 3 25 12.00 189232.98 4

043 Surgery 110278.07 3 21 14.28 472175.48 9

044 Toxicology 61380.73 2 9 22.22 373688.53 4

045 Vision and ophthalmology 554035.25 9 35 25.71 799551.33 12

046 Nuclear medicine 0.00 0 3 0.00 63307.30 2

047 Genetics 387259.16 6 34 17.64 1408230.46 17

048 Public Health 0.00 0 17 0.00 58588.20 1

2973068.56 3159747.32 2529765.60 1050247.96

1465994.57 2114526.72 325401.69 582453.55

435069.26 1353586.58 63307.30 1795489.62

58588.20

42 53 48 17

23 35 7 12

6

21 2

23 1

59935067.58

NB: The above disciplines do NOT reflect ALL grants supported during 1994.

INSTITUTE AND CENTRE BLOCK GRANTS FOR 1994

REGKEY Amount

Awarded $

Remew Year

Prof. G. Nossal Walter and Eliza Hall Institute 913212 6,552,431.98 1991 - 95

Prof. J. Coghlan Howard Florey Institute

923001 4,819,145.62 1992-96

Prof. D. Danks Murdoch Institute for Research into Birth Defects

923051 1,087,966.65 1992-96

Prof. J. Funder Baker Medical Research Institute 933001 3,181,199.72 1993-97

Prof. J. Shine Garvan Institute of Medical Research 933050 2,297,531.41 1993-97

BRIDGING SUPPORT 1994 REGKEY Future support

$ 1995 1996

NEW SOUTH WALES Royal North Shore Hospital

A /Prof. P. Ghosh Prof. T. Taylor Raymond Purves Research Laboratories the causes of disc degeneration

Project Bridging Support starting in 1994 940048 54,087.62 No No

49

Bridging S upport 1994 coni. R E G K E Y F u tu r e su p p o r t

_____________________________________________________________ $ 1995 1996

University of New South Wales Dr N. O'Dwyer Dr P. Neilson Ms L. Ada Neurology Recovery of movement in stroke compared

with cerebral palsy Project Bridging Support starting in 1994 941002 59,989.20 No No NEW SOUTH WALES University of Sydney

Prof. G. Broe Dr H. Creasey Prof. C. Harper Dr W. Brooks .

Geriatrics Research program on the ageing brain Project Bridging Support starting in 1994 940015 46,400.36 N o No

VICTORIA Monash University Dr B. Adler Prof. S. Paine Microbiology How leptospires cause disease and how im m unity to infection functions Project Bridging Support starting in 1994 940942 61,715.16 No No

Prince Henry's Institute of Medical Research Dr J. Clements Endocrinology Kallikrein-like enzymes in the uterus Project Bridging Support starting in 1994 941011 59,007.86 No No

University of Melbourne Dr P. Busby Prof. G. Clark Dr P. Blarney Otolaryngology Studies of hearing in children using cochlear implants Project Bridging Support starting in 1994 940208 54,813.57 No No

50

Bridging S u p p o rt 1 9 9 4 cont, REGKEY Future support

$ 1995 1996

U niversity of M elbourne Dr W. Phillips Surgery Regulation of phagocyte function by inflam m atory mediators Project Bridging Support continued from 1993 931431 58,812.45 No No

UNIT GRANTS 1994

REGKEY

$

Future support 1995 1996

NEW SOUTH WALES University of Sydney Dr R. Simes Research Unit Grant continued from 1993

VICTORIA

933302 525,841.01 Yes Yes

M ental H ealth Research Institute of Victoria Prof. D. Copolov Prof. B. Singh Research Research Unit Grant continued from 1992 923301 341,980.31 Yes Yes

Prof. D. Copolov Research Brain network Research Unit Grant starting in 1994

QUEENSLAND

943302 507,698.92 Yes Yes

U niversity of Q ueensland Dr A. Seawright Toxicology National Centre for Environmental Toxicology Research

Research Unit Grant continued from 1991 913301 544,833.31 Yes No

SOUTH AUSTRALIA U niversity of A delaide Dr A. Mclean NHMRC Road Accident Research Unit

Research Unit Grant starting in 1994 943301 457,757.63 Yes Yes

51

AUSTRALIAN CAPITAL TERRITORY Australian National University Prof. A. Henderson Research Unit Grant continued from 1993 933301 744,096.90 Yes Yes

R DOUGLAS WRIGHT AWARDS Nam e & REG K EY Institution Level of Appointm ent

Dr R. Barnard University of Queensland Senior Research Officer

947704 Level 2

Dr J. Brock University of Newcastle Senior Research Officer

947768 Level 1

Dr P. Cameron Macfarlane Burnet Centre for Senior Research Officer

947764 Medical Research Level 6

Dr D. Calermajer Heart Research Institute Senior Research Officer

947706 Level 1

Dr H. Christensen Australian National University Senior Research Officer 947769 (NHMRC Social Psychiatry Level 1

Research Unit)

Dr A. Fosang University of Melbourne Senior Research Officer

947765 Level 1

Dr S. Jane Monash University Senior Research Officer

947728 Level 1

Dr C. Jones Royal Children's Hospital Research Senior Research Officer 947729 Foundation Level 1

Dr M. Lewitt Royal Prince Senior Research Officer

947770 Alfred Hospital Level 1

Dr D. Pow University of Queensland Senior Research Officer

947740 Level 1

Dr H. Richardson University of Adelaide Senior Research Officer

947742 Level 4

52

R D ouglas W right A w ard s coni. Name & REGKEY Institution Level of Appointment

Dr D. Spina 947751

University of Western Australia

Senior Research Officer Level 1

Dr E. Storey 947749

University of Melbourne Senior Research Officer

Level 1

Dr M. Veronese 947755 The Flinders University of South Australia

Senior Research Officer Level 1

Dr H. Young 947759

University of Melbourne Senior Research Officer

Level 1

SPECIAL INVESTIGATIONS 1994 REGKEY Future support

$ 1995 1996

OVERSEAS Auckland Hospital Dr S. MacMahon Medicine

Pulm onary Embolism Prevention Trial Special Investigations starting in 1994 942805 6,000.00 No No

NEW SOUTH WALES

Royal Prince Alfred Hospital Dr A. Phippard Renal Medicine Baboon Colony Support Special Investigations continued from 1993 931429 50,024.48 Yes No

University of Sydney Prof. P. Reeves Microbiology Australian National Genomic Information Service Special Investigations starting in 1994 942806 100,000.00 No No

53

Special Investigations 1 9 9 4 cant, R E G K E Y F u tu r e su p p o r t

_____________________________________________________________ $ 1995 1996

VICTORIA

Baker Medical Research Institute Dr W. Anderson Research Research Assistant for Animal Experimentation Ethics Committee Special Investigations starting in 1994 942803 26,082.40 Yes Yes

Dr W. Anderson Research Animal Welfare Workshops Special Investigations starting in 1994 942807 10,000.00 No No

Howard Florey Institute Dr J. Mcdougall Physiology Research Evaluation Special Investigations starting in 1994 942801 45,167.79 Yes Yes

University of Melbourne Prof. I. Darian-Smith Anatomy Macaque Colony Support Special Investigations continued from 1993 931428 49,539.00 Yes No

Dr J. Hopper Medicine Australian NHMRC Twin Registry Special Investigations continued from 1993 931426 84,258.41 Yes Yes

SOUTH AUSTRALIA

Australian Council for the Care of Animals for Research and Teaching Dr R. Baker Research Australian Council for the Care of Animals in Research and Teaching Special Investigations starting in 1994 942804 30,000.00 Yes Yes

54

Special Investigations 1994 cant. REGKEY $ Future support

1995 1996

Adelaide Medical Centre for Women and Children Prof. G. Sutherland Cytogenetics H um an Genome Organisation contribution

Special Investigations starting in 1994 942802 50,000.00 Yes Yes

CSIRO, S.A. Division Prof. P. Nestel H um an Nutrition Marmoset Colony Support

Special Investigations continued from 1993 931430 20,220.00 No No

55

Project G rants NEW SOUTH WALES

REGKEY Future supoport

__________________________________________________________ $_____________1995 1996

C entenary In s titu te of Cancer M e d icin e and C e ll B io lo g y Dr B. Fazekas De St. Groth Research The control of the im m une response Standard Project continued from 1993 930167 42,300.51 Yes No

Dr J. Sedgwick A /Prof. J. Pollard Research Development of dam aging im m une response in the central nervous system

Standard Project continued from 1992

Children's M edical Research In stitu te Dr P. Gunning Genetics Control of cell structure Standard Project continued from 1992

Dr E. Hardeman Dr K. Esser Dr P. Gunning Muscle Development Control of muscle repair following injury Standard Project continued from 1993

Dr E. Hardeman Muscle Development Analysis of skeletal muscle maturation Standard Project starting in 1994

Dr R. Red del Genetics Can the p53 gene control the unlimited proliferation of cancer cells?

Standard Project continued from 1992

Dr R. Red del Cancer Research Unit Identification of genes involved in disordered growth of cancer cells

920597 43,273.41 No No

920175 171,802.39 Yes Yes

930990 46,164.69 Yes No

940507 74,682.37 Yes Yes

920686 46,149.45 No No

56

Standard Project starting in 1994 940500 76,580.82 Yes Yes

REGKEY Future supoport

$ 1995 1996

Dr P. Tam Embryology Germ layer developm ent in m ouse embryos Standard Project starting in 1994 940502 79,599.07 Yes Yes

Dr R. Weinberger Neurobiology Control of neuronal structure Standard Project continued from 1993 930330 38,600.62 Yes No

Heart Research In s titu e Dr D. Celermajer Cardiology Early blood vessel disease: is it reversible in adults at high risk? Standard Project starting in 1994 940264. 5,055.00Yes Yes

Prof. R. Dean Cell Biology Does protein dam age play a significant role in ageing

Standard Project continued from 1993 930230 42,118.99 Yes No

Prof. R. Dean Cell Biology Metals and lipoprotein oxidation Standard Project starting in 1994 940914 40,295.43 Yes Yes

Dr C. Geczy Dr P. Ale wood Immunology

Studies of basic mechanisms of inflammation Standard Project continued from 1993 930345 44,321.70 Yes No

Dr C. Geczy Im m unology Characterisation of new proteins m ediating inflam m ation

Standard Project continued from 1993 930617 179,349.11 Yes Yes

57

REGKEY

$

Future supoport 1995 1996

Heart Research Institue cont. Dr C. Geczy Dr S. Iismaa Im m unology Characterisation of cell receptors of a novel protein involved in cell migration Standard Project starting in 1994

Dr W. Jessup Dr J. Dawes Cell Biology Control of lipid deposition in the artery wall Standard Project continued from 1992

Dr W. Jessup Cell Biology Docs nitric oxide prevent atherosclerosis? Standard Project starting in 1994

Dr R. Stocker Biochemistry Why do cells degrade tryptophan? Standard Project continued from 1992

Dr R. Stocker Biochemistry Lipoprotein oxidation and antioxidation Standard Project starting in 1994

In s titu te o f D ental Research Dr N. Jacques Dr P. Giffard Dentistry Enzymes that build up plaque on teeth Standard Project continued from 1993

Dr N. Jacques Dentistry A bacterial enzyme that aids in bacterial proliferation in the m outh Standard Project starting in 1994

940257 72,382.22 Yes Yes

1 I

920874 49,909.99 No No

940891 34,059.31 Yes Yes

l

920371 46,374.92 No No

940915 147,427.99 Yes Yes

930498 48,384.69 Yes No

940038 45,350.43 Yes Yes

58

REGKEY

$

Future supoport 1995 1996

John H u n te r H o sp ita l Dr J. Leitch Cardiovascular M edicine Physical training and baroreflexes after

m yocardial infarction Standard Project starting in 1994

Dr P. Robinson Endocrine Unit The role of a new brain-specific protein, dephosphin, in neurotransm ission Standard Project continued from 1992

M acquarie U n iv e rs ity

Dr G. Lawrence A /Prof. J.W halley Biological Science H erpesvirus infection: study of the role of a conserved gene in the virus life cycle Standard Project continued from 1993

Dr G. Rossmanith Dr J. Hoh Mathematics Mechanisms whereby nerves control the

functions of the heart Standard Project continued from 1993

Dr H. Stokes Dr R. Hall Biological Science Spread of antibiotic resistance by a novel DNA

element Standard Project continued from 1992

Dr H. Stokes Dr R. Hall Biological Science The spread of antibiotic resistance in bacteria

Standard Project continued from 1993

940983 29,739.44 Yes No

920502 47,401.20 No No

931254 51,819.65 Yes No

931102 36,055.02 Yes No

920752 58,387.47 No No

930505 40,097.80 Yes No

59

RECKEY $

Future supoport 1995 1996

M acquarie U n iv e rs ity cont.

Prof. K. Williams Dr K. Emslie Prof. R. Raison Biological Science New vaccines produced by genetic engineering Standard Project continued from 1992 920275 63,823.55 No No

Prof. K. Williams Dr M. Slade Dr K. Emslie Biological Science Protection against cryptosporidiosis: an intestional infection from water Standard Project starting in 1994 940418 50,829.39 Yes Yes

M ater M isericordiae H ospital, Newcastle Prof. P. Hersey Oncology

Analysis of im m une responses to hum an m elanoma Standard Project continued from 1993 930009 76,277.53 Yes No

Prince H e n ry and Prince o f Wales H ospital A /Prof. J. Charlesworth A /Prof. B. Pussell Dr C. Morris Medicine Does inhibition of inflammatory plasma proteins reduce kidney filter damage Standard Project continued from 1993 930604 46,745.10 Yes No

Royal N o rth Shore H o sp ita l Dr B. Baldo Dr G. Donovan Dr S. Sutherland Rolling Institute of Medical Research Allergic reactions to ant stings Standard Project continued from 1992 920958 39,883.98 No No

Dr N. Manolios Rheumatology M apping structural determ inants on T-cell antigen receptor chains necessary for assembly Standard Project starting in 1994 940057 34,794.44 Yes Yes

60

REGKEY $

Future supoport 1995 1996

Royal N o rth Shore H o sp ita l cont.

A /Prof. C. O 'N eill Hum an Reproduction Unit How em bryos m ake their own grow th stimulant

Standard Project continued from 1993 930122 46,771.04 Yes No

A /Prof. R. Smith Prof. M. Cousins Prof. L. M ather Dr S. Barratt

Anaesthesia Pain m anagem ent and intravenous feeding for surgical patients Standard Project continued from 1992 920985 45,219.00 No No

Dr H. Ward A /Prof. N. Berend Thoracic Medicine The effect of radiation on the tissues of the lung Standard Project continued from 1992 920981 47,902.49 No No

Royal Prince Alfred Hospital Dr S. Anderson Respiratory Medicine Dehydration of the airways and asthma

Standard Project starting in 1994 940439 69,313.33 Yes Yes

Dr R. Baxter Dr S. Firth Dr J. Martin Endocrinology The way in which the growth factor binding

protein igfbp-3 binds to proteins and cells Standard Project starting in 1994 940447 121,518.18 Yes Yes

Dr C. Bishop A /Prof. C. M cCaughan Prof. A. Sheil G astroenterology

What are the mechanisms of acceptance of transplanted liver? Standard Project starting in 1994 940430 37,506.99 Yes Yes

61

REGKEY Future supoport

$ 1995 1996

R oyal Prince A lfre d H o sp ita l cont.

Dr P. Bye Mr D. Bailey Dr G. Bautovich Nuclear Medicine New treatm ents to clear m ucus and aid breathing in cystic fibrosis Standard Project continued from 1993 930322 39,351.49 Yes No

Dr I. Caterson Dr P. Williams Dr L. Storlien Mrs J. Bryson Endocrinology Do muscles use sugar differently in obesity? Standard Project continued from 1993 930353 55,475.54 Yes No

Dr G. Cooney Dr I. Caterson Medicine The role of glucocorticoid hormones in the

control of obesity Standard Project continued from 1992 920544 99,937.06 Yes Yes

A /Prof. S. Dunn A /Prof. A. Coates Dr P. Butow Oncology The effects of psychological factors on breast cancer and melanoma Standard Project starting in 1994 940419 57,724.66 Yes Yes

Dr M. Gardiner-Garden Dr S. Clark Dr D. Tremethick Biomolecular Engineering Exploring the role in developm ent played by DNA structures called "CpG islands" Standard Project starting in 1994 940497 52,255.55 Yes Yes

62

RECKEY

$

Future supoport 1995 1996

Royal Prince A lfre d H o sp ita l cent.

Dr A. Gillin Dr G. Duggin Renal M edicine Prim ate urea transport Standard Project starting in 1994 940859 34,731.51 Yes Yes

Dr G. Halm agyi Dr I. C urt hoys Mr M. Todd Neurology

Inner ear balance functions Standard Project continued from 1993 930287 41,529.20 Yes No

Mr B. H utton Mr D. Bailey Dr R. Jeremy Dr M. Yeates Nuclear Medicine

Improved im aging of myocardial blood flow using quantitative photon emission tomography Standard Project continued from 1992

Dr H. Hand Dr P. Molloy Ms J. Thorn Kanematsu Memorial Inst. Res. Lab

Characterisation of the control region of a cancer-associated gene Standard Project continued from 1992

Dr H. Hand Dr G. Young Kanematsu Memorial Inst. Res. Lab A sensitive m ethod for detection of residual

leukemia and incipient relapse Standard Project continued from 1993

A /Prof. D. Joshua Mr R. Brown Dr J. Gibson H aem atology

A study of mechanisms of relapse in myeloma Standard Project continued from 1992

920036 31,303.11 No No

920545 64,700.36 No No

930270 42,181.15 Yes No

920546 50,150.20 No No

63

REGKEY Future supoport

__________________________________________________________ $_____________1995 1996

Royal Prince A lfre d H o sp ita l cont.

Dr M. Lewitt Dr R. Baxter Medicine Role of proteins which bind insulin-like grow th factors in the circulation Standard Project starting in 1994

A /Prof. G. McCaughan Dr M. Gorrell Gastroenterology and Liver Unit Structure of the liver molecule dpp-iv Standard Project starting in 1994

Dr B. O'Sullivan Dr J. Watson Dr D. Kavanagh Dr P. Michie Nuclear Medicine PET and MRI studies of the brain: thinking and m em ory in health and schizophrenia Standard Project starting in 1994

Dr C. Scott Medicine Regulation of proteins involved in mediating insulin-like growth factor type II action Standard Project starting in 1994 940472 148,458.92 Yes Yes

Dr L. Storlien Endocrinology How saturated fats in muscle cell walls lead to diseases like diabetes and obesity Standard Project starting in 1994 940885 96,461.21 Yes Yes

St. Vincent's Hospital, Sydney A /Prof. K. Atkinson A /Prof. J. Biggs Dr P. Kearney Dr K. Scott

Haematology Development of new drugs to treat leukemia by genetic engineering Standard Project continued from 1992 920417 45,219.00 No No

941164 38,932.30 Yes Yes

940860 46,789.77 Yes Yes

940864 50,620.77 Yes Yes

64

St. V incent's H o s p ita l, Sydney cont.

Dr S. Breit Dr G. Morgan Im m unology Lung injury associated w ith radiotherapy

Standard Project continued from 1992

Dr S. Breit Im m unology Localisation and processing of platelet derived growth factor

Standard Project starting in 1994

Dr M. Cooley Ms C. Farrell Im m unology Im m une responses predicting complications

after bone m arrow transplant Standard Project continued from 1992

U n iv e rs ity of Newcastle

Dr M. Agrez Prof. G. Burns Cancer Research Unit cell-adhesion receptors in large bowel cancer

Standard Project continued from 1993

Dr K. Beagley Pathology B cells in mucosal immunity

Standard Project starting in 1994

Prof. B. Boettcher A /Prof. J. McCluskey Dr R. Dunstan Biological Science Processing viral coat protein by aboriginal hepatitis b carriers and those with im m unity Standard Project starting in 1994

D r). Brock Dr D. Van Helden H um an Physiology Neural control of blood vessels Standard Project starting in 1994

REGKEY Future supoport

$ 1995 1996

920044 47,054.06 No No

940118 48,621.26 Yes Yes

920554 41,641.51 No No

931048 66,303.16 Yes No

940578 38,273.43 Yes Yes

940576 10,000.00 No No

940501 9,099.00 Yes Yes

65

REGKEY

$

Future supoport 1995 1996

U n iv e rs ity of Newcastle cont.

Dr S. Bunn A /P ro f. P. Dunkley M edical Biochemistry M olecular regulation of hormone releasing cells S tandard Project continued from 1992

Prof. G. Burns Dr J. Gani Cancer Research Unit A nalysis of a receptor involved in cell migration Standard Project continued from 1992

Prof. G. Burns Dr M. Agrez M edicine H ow colon cancer cells attach together Standard Project continued from 1992

Prof. G. Burns M edicine U nderstanding how cells move Standard Project continued from 1993

Prof. V. Carr Mr T. Lewin Psychiatry Abnorm alities of attention in schizophrenia Standard Project continued from 1992

A /P ro f. L. Chahl Clinical Pharmacology Interactions between opioid and tachykinin neurones in the brain Standard Project starting in 1994

Prof. R. Clancy Dr G. Pang A /P rof. A. Cripps Pathology Lymphocytes in sputum drive inflammation Standard Project starting in 1994

920746 45,341.08 No No

920681 58,409.66 No No

920684 ' 64,833.24 No No

930359 41,289.91 Yes No

920669 35,519.84 No No

940519 66,149.94 Yes Yes

940952 51,183.29 Yes Yes

I

6 6

REGKEY $

Future supoport 1995 1996

U n iv e rs ity of Newcastle cont.

A /Prof. A. Cripps Dr M. D unkley Prof. R. Clancy Pathology

Im m unity to pathogenic bacteria in the lung Standard Project starting in 1994 940492 87,141.63 Yes Yes

Prof. A. Dobson Prof. R. Heller Clinical Epidemiology M onitoring trends and determ inants of cardiovascular disease Standard Project continued from 1993 930357 118,423.35 Yes No

A /Prof. P. Dunkley Medicine The control and function of a calmodulin-kinase Standard Project continued from 1993 930383 80,982.41 Yes No

Prof. J. Forbes Dr M. Byrne Dr J. Collins A /Prof. A. Coates

Oncology Chem otherapy trials for women with node negative operable breast cancer Standard Project continued from 1992 920876 99,026.82 No No

Prof. J. Forbes Dr D. Joseph Dr J. Collins A /Prof. A. Coates Surgery

Optimal treatm ent for pre invasive breast cancer in women Standard Project continued from 1993 930428 17,237.84 Yes No

67

REGKEY

$

Future supoport 1995 1996

U n iv e rs ity of Newcastle cont.

Prof. J. Forbes A /Prof. A. Coates D rM . Byrne Dr R. Snyder Oncology New treatm ent trials for women with early breast cancer and involved lym ph glands Standard Project starting in 1994

Dr P. Gibson Respiratory Medicine Airway inflammation in asthma Standard Project starting in 1994

Dr P. Robinson A /Prof. R. Smith Dr J. Liu Endocrine Unit M echanism regulating stress horm one release by the pituitary Standard Project continued from 1993

A /Prof. J. Rostas A /Prof. J. Heath Medicine Molecular mechanisms that regulate the responsiveness of nerve cells Standard Project continued from 1992

Dr P. Sah Dr D. Van Helden Physiology Regulation of calcium in nerve cells Standard Project continued from 1993

Dr J. Silberberg Medicine Why do some families develop chd? A population-based study of men and women Standard Project starting in 1994

940892 102,795.85 Yes Yes

940316 37,092.31 Yes Yes

930468 75,174.71 Yes No

920925 102,285.50 No No

930469 4,396.09 Yes No

941169 34,729.88 Yes Yes

6 8

REGKEY $

Future supoport 1995 1996

U n iv e rs ity of Newcastle cont.

Dr A. Sim A /Prof. P. D unkley A /Prof. J. Rostas Medical Biochemistry The control of key regulatory molecules in the brain

Standard Project continued from 1992 920921 61,006.85 No No

A /Prof. R. Smith Endocrinology Placental corticotrophin-releasing hormone

Standard Project continued from 1992 920400 100,253.53 No No

Dr D. Van Helden H um an Physiology >

A basis for lymphatic pum ping Standard Project continued from 1993 930440 106,365.76 Yes Yes

Dr B. Walmsley Medical Biochemistry Connections between nerve cells in the central nervous system

Standard Project continued from 1992 920230 150,379.94 Yes Yes

Prof. W. Walters Prof. A. Boura O bstetrics/G ynaecology Effects of reduced placental oxygen in high blood

pressure of pregnancy Standard Project continued from 1992 920922 40,688.80 No No

Prof. S. White Dr A. Quail H um an Physiology Cardiac reflex control of bronchial and coronary circulations Standard Project starting in 1994 940967 56,341.12 Yes Yes

U n iv e rs ity of N e w South Wales Dr K. Ashwell Anatomy

The inner ear and the developm ent of the brainstem Standard Project continued from 1993 931248 45,038.55 Yes No

69

REGKEY

$

Future supoport 1995 1996

U n iv e rs ity of N ew South Wales cont.

Dr A. Bagnara Dr M. Edwards Prof. I. Dawes Biochemistry Developm ent of new drugs against sexually-transm itted disease caused by trichom onas Standard Project starting in 1994

A /Prof. P. Barry Physiology and Pharmacology How ions pass through GABA and glycine activated channels Standard Project continued from 1993

A /Prof. A. Blaszczynski Prof. D. Si love Prof. K. Hillman Dr D. Sloane Mental Health The nature and extent of emotional and psychiatric

disabilities after motor vehicle accidents Standard Project starting in 1994

Dr B. Brew Mr M. Perdices A /Prof. J.K aldor Immunology Predicting and improving treatm ent of AIDS dem entia Standard Project continued from 1992

Prof. H. Brodaty Dr P. Sachdev Dr P. Kitchener Psychogeriatric Schizophrenia in the elderly Standard Project continued from 1992

Dr E. Burcher Physiology and Pharmacology Actions of tachykinin peptides in bladder, gut and brain Standard Project continued from 1993

940978 44,157.85 Yes Yes

930704 60,794.30 Yes No

941163 35,888.28 Yes Yes

j

920213 43,273.41 No No

)

I

920211 43,624.55 No No

\

|

931200 167,449.44 Yes Yes

70

I

REGKEY Future supoport

$ 1995 1996

U n iv e rs ity of N e w South Wales cont. Prof. D. Burke Dr I. M ogyoros Research

Abnormal conduction in hum an nerves Standard Project starting in 1994 940958 58,611.67 Yes Yes

Prof. D. Burke A /Prof. S. Gandevia Clinical N europhysiology m icroneurography and m otor control in man 5 yr extended grant continued from 1991 910614 229,058.21 Yes No

A /Prof. T. Campbell Dr D. Martin Clinical Pharmacology Antiarrhythmic d ru g action in simulated

ischaemia Standard Project starting in 1994 940904 50,054.61 Yes Yes

Dr S. Catts Dr P. Ward A /Prof. D. Wakefield Prof. G. Paxinos Pathology and Immunology Neurochem istry in the tem poral lobe in

schizophrenia Standard Project starting in 1994 940964 45,072.90 Yes Yes

Dr J. Colcbatch Medicine Activating the balance organ by clicks Standard Project continued from 1993 931188 40,178.26 Yes No

Dr I. Cook Dr D. H unt Dr D. De Carle

Gastroenterology Studies on diseases of swallowing Standard Project continued from 1992 920218 64,509.15 No No

71

U n iv e rs ity of N ew South Wales cont.

Dr I. Cook Dr D. De Carle Dr D. Lubowski Medicine Studies on colonic propulsion in health and in constipation Standard Project starting in 1994

Dr S. Crewther A /Prof. D. Crewther Optometry Acuity loss in strabismic amblyopia Standard Project starting in 1994

Dr P. Curmi Dr B. Hambly Physics A study of the proteins that control force generation in muscle and other cells in the body Standard Project starting in 1994

Dr J. Dangain A /Prof. I. Neering Physiology and Pharmacology Membrane function in dystrophic and pre-dystrophic mouse muscles Standard Project continued from 1992

Prof. R. Day Prof. J. Miners Prof. D. Birkett A /Prof. G. Graham Clinical Pharmacology

Allopurinol actions in man Standard Project continued from 1992

Prof. R. Day Dr D. Cutler Dr S. Tett Clinical Pharmacology Rational therapy of rheumatic diseases with hydroxychloroquine Standard Project continued from 1992

REGKEY Future supoport

$ 1995 1996

940465 32,981.16 Yes Yes

>

940531 52,907.27 Yes Yes

940534 44,157.85 Yes Yes

I

920877 52,433.42 No No

I I rl

920221 58,329.08 No No

' I

920932 40,709.99 No No

72

REGKEY $

Future supoport 1995 1996

U n iv e rs ity o f N e w South Wales cont.

Dr N. D udm an Prof. D. Wilcken Prof. C. Chesterm an Medicine

Vascular dam age and sulphur-containing am ino acids Standard Project continued from 1992 920363 106,783.61 Yes Yes

Dr K. D uggan Prof. G. M acdonald H ypertension Unit Interactions of horm ones involved in body

sodium regulation Standard Project continued from 1993 931201 43,391.95 Yes No

Dr M. Duncan Medicine DNA dam age and the ageing brain Standard Project starting in 1994 940588 45,774.39 Yes Yes

Dr R. Faull Medicine How white blood cells use adhesion molecules to migrate to sites of inflammation Standard Project starting in 1994 940884 37,092.31 Yes Yes

A /Prof. M. Feneley Medicine Study of the heart's ability to adapt to altered pum ping requirem ents

Standard Project continued from 1993 931218 49,355.26 Yes No

Prof. M. Fraser Children's Leukaem ia/C ancer Research Unit DNA repair and cell death m ediated by the same hum an enzym e

Standard Project continued from 1992 920393 42,549.72 No No

Dr A. Gero Biochemistry Targetting new drugs through the m em brane of the m alaria parasite

Standard Project starting in 1994 940589 151,063.05 Yes Yes

73

REGKEY

$

Future supoport 1995 1996

U n iv e rs ity of N ew South Wales cont.

Prof. J. Hales Physiology and Pharmacology Some factors which may cause failure of body tem perature during heat stress Standard Project continued from 1993 931220 67,230.52 Yes No

Dr B. Hall Medicine Studies on the mechanisms that lead to early and late rejection of transplanted organs Standard Project continued from 1992 921129 175,537.47 No No

Prof. B. Hall Medicine Studies on im m une m ediators of injury in

nephritis ·

Standard Project starting in 1994 940965 49,394.43 Yes Yes

Dr S. Hazell Dr H. Mitchell Microbiology and Immunology U nderstanding the spread of bacterial infection may help to prevent gastric cancer Standard Project starting in 1994 940882 51,334.89 Yes Yes

Dr I. Hickie Dr A. Wilson Mr D. Hadzi-Pavlovic Psychiatry Is chronic fatigue a common complaint in general practice?

Standard Project continued from 1993 931215 64,389.08 Yes No

Prof. G. Jackson Dr W. Sewell Microbiology and Immunology Im m une activity in the liver Standard Project starting in 1994 940333 41,306.43 Yes Yes

74

REGKEY

$

Future supoport 1995 1996

U n iv e rs ity of N e w South Wales cont.

Dr R. Kelly A /Prof. M. Feneley Cardiac Surgery The effect of hardening of the arteries on the

perform ance of the heart Standard Project continued from 1993 931209 97,886.90 Yes No

Dr S. Krilis Medicine Proteins that interfere with blood clotting Standard Project continued from 1993 931221 83,227.40 Yes No

Dr S. Krilis Medicine Investigation of cells and grow th factors involved in allergic disease

Standard Project starting in 1994 940554 47,838.70 Yes Yes

Dr T. Kron Physics High resolution dosim etry of therapeutic radiation in three dim ensions

Standard Project continued from 1993 930734 15,158.93 No No

A /Prof. R. Kumar Pathology Role of cells lining the airspaces in the developm ent of chronic lung scarring

Standard Project starting in 1994 940322 42,467.87 Yes Yes

Prof. A. Lee Microbiology and Immunology Exploration of strategies for the prevention of gastroduodenal disease

Standard Project continued from 1993 931211 64,159.03 Yes Yes

Dr F. Levy Dr D. Hay Child Psychiatry Hyperactivity in twins

Standard Project starting in 1994 940877 56,823.10 Yes Yes

75

REGKEY

$

Future supoport 1995 1996

University of New South Wales cont. Prof. E. Lumbers School of Physiology & pharmacology Control of fetal and neonatal fluid and electrolyte balance Standard Project continued from 1992 920136 85,444.48 No No

Prof. E. Lumbers Dr A. Stevens School of Physiology & pharmacology Why do drugs that block angiotensin cause fetal distress?

Standard Project continued from 1993 930515 43,695.13 Yes No

Dr B. Mabbutt Biochemistry Characterisation of the molecular structure of '

leukaemia inhibitory factor Standard Project continued from 1992 920139 38,104.20 No No

Prof. E. McLachlan Medical Research How sympathetic nerves control different tissues Standard Project continued from 1993 930521 180,981.48 Yes Yes

Prof. E. McLachlan Research Sympathetic effects after peripheral nerve dam age Standard Project starting in 1994 940909 30,217.51 Yes Yes

Dr C. Mcndz Dr S. Ha/.cll Biochemistry Studies of metabolism of bacterium: the aetiological agent of acute chronic gastritis Standard Project continued from 1992 920358 101,213.57 No No

A /Prof. P. Mitchell Prof. B. Waters A molecular genetic study of manic-depressive illness Standard Project starting in 1994 940957 47,247.42 Yes Yes

76

RECKEY Future supoport

$ 1995 1990

U n iv e rs ity o f N e w South Wales cont.

Dr V. M urray Dr G. Wickham Dr W. M cFadyen Biochemistry

A new m ethod to determ ine DNA sequences dam aged by the anti-tum our agent cisplatin Standard Project continued from 1992 920216 41,205.73 No No

Prof. G. Parker Mr D. Hadzi-Pavlovic Dr I. Hickie Dr K. Wilhelm Psychiatry

Sub-grouping depressive disorders by clinical features and causes Standard Project continued from 1993 931196 86,929.01 Yes No

Prof. G. Paxinos Psychology The hum an brain: identification of its regions and an electronic atlas

Standard Project continued from 1991 910669 85,274.17 No No

A /Prof. M. Perry Physiology and Pharmacology Why do drugs used to treat joint pain cause gut ulcers Standard Project continued from 1993 931173 43,141.32 Yes No

Dr E. Potter Prof. D.I. McCloskey Research Regulation of the heart and blood vessels by the

nervous system 5 yr extended grant continued from 1993 931177 267,598.24 Yes Yes

Prof. M. Rowe Dr J. Morley Dr G. M urray Physiology and Pharmacology Brain m echanism s in sensation Standard Project continued from 1992 920351 88,862.36 Yes Yes

77

REGKEY Future supoport

$ 1995 1996

U n iv e rs ity of N ew South Wales cont.

Dr P. Sachdev Neuropsychiatry Characteristic of late-onset restlessness due to antipsychotic drugs Standard Project continued from 1992 920233 36,699.03 No No

A /Prof. P Schofield Dr M. Edwards Prof. W. O'Sullivan Biochemistry New pathways of fuel metabolism in Giardia Standard Project continued from 1992 920768 57,388.42 No No

Dr W. Sewell Immunology Control of growth factor production by steroids and other drugs Standard Project starting in 1994 940950 42,965.28 Yes Yes

Dr T. Stewart Prof. W. O'Sullivan Biochemistry Human malarial enzymes as chemotherapeutic targets Standard Project continued from 1992 920763 43,273.41 No No

Dr G. Symonds Prof. P. Rowe Clinical Pathology Use of genetically altered im m ature bone marrow cells to induce leukaemia Standard Project continued from 1992 920721 125,733.41 Yes Yes

A /Prof. D. Tracey Dr J. Walker Anatomy The sympathetic nervous system in chronic pain

Standard Project continued from 1993 931234 37,247.53 Yes No

Dr B. Tuch Medicine Resistance to diabetes of the hum an fetal beta cell Standard Project continued from 1992 920103 54,540.05 No No

78

REGKEY Future supoport

1995 1996

U n iv e rs ity o f N e w South Wales cont.

Dr B. Tuch Dr S. M ackowiak Dr X. D ennett Endocrinology The fetal beta cell

Standard Project starting in 1994

A /Prof. G. Turner Genetics Retardation results if the gene changes size — w hat size is just right?

Standard Project continued from 1993

Dr P. Waite Anatomy Chemical pathw ays in the brain Standard Project continued from 1992

Dr P. Waite Anatom y A study of dual sensory nerve pathw ays Standard Project continued from 1992

940840 49,818.39 Yes Yes

931235 50,809.06 No No

920881 50,405.86 No No

920884 20,329.78 No No

Dr P. Ward Dr S. Catts Dr P. Michie Dr S. Andrews

Psychiatry Relationship between brain structure and function m easures in schizophrenia

Standard Project continued from 1992 920183 85,570.32 No No

Prof. J. W hitworth Medicine H ow steroids raise blood pressure Standard Project starting in 1994 940351 45,871.80 Yes Yes

Prof. D. Wilcken Dr Xi Wang Prof. C. McGilchrist Dr B. McDonald M edicine Genes and coronary heart disease Standard Project starting in 1994 940521 56,120.61 Yes Yes

79

REGKEY Future supoport

$ 1995 1996

U n iv e rs ity o f N ew South Wales cont.

Dr K. Wilhelm Prof. G. Parker Psychiatry Longitudinal study of sex differences in depressive experience: a 15 year follow-up Standard Project starting in 1994 940448 35,888.28 Yes No

Dr K. Williams Prof. R. Day Clinical Pharmacology U nderstanding the therapeutic and toxic effects of drugs used in arthritis Standard Project continued from 1993 930516 61,983.21 Yes No

U n iv e rs ity of Sydney Prof. D. Allen Physiology Why muscles become weak during intense exercise Standard Project continued from 1993 931008 67,703.01 Yes No

Prof. D. Allen Physiology Intracellular calcium and muscle damage Standard Project starting in 1994 940012 36,635.61 Yes Yes

Dr C. Armour A /Prof. J. Black Pharmacy U nderstanding the interactions between cells in asthma Standard Project continued from 1993 930041 52,729.19 Yes No

Dr V. Balcar Dr B. Dreher Prof. W. Burke Anatomy Location of excitatory nerve endings in brain Standard Project continued from 1993 931018 42,877.35 Yes No

80

REGKEY Future supoport

$ 1995 1996

U n iv e rs ity o f S ydney cont.

Dr B. Baldo Dr G. Donovan Kolling Institute of Medical Research Studies in allergy to drugs and environmental

antigens Standard Project starting in 1994 940036 133,684.63 Yes Yes

A /Prof. R. Bandler Dr P. Carrive Dr M. Christie Dr P. Davis

Anatomy N eural mechanism s m ediating physiological responses to stress Standard Project continued from 1992 920345 52,617.61 No No

A /Prof. R. Bandler Dr K. Keay Anatomy and Histology Neural m echanisms of pain Standard Project starting in 1994 940527 55,378.89 Yes Yes

Dr J. Barden Anatomy Elucidation of the structure of parathyroid horm one related protein

Standard Project continued from 1992 920896 108,671.46 Yes Yes

Prof. M. Bennett Physiology M ethods of com munication betw een nerves Standard Project continued from 1993 931032 49,441.68 Yes No

Prof. M. Bennett Dr W. Phillips Dr W. Gibson Physiology

Electrical current flow in smooth muscle during synaptic transm ission Standard Project starting in 1994 940623 35,240.43 Yes Yes

81

REGKEY Future supoport

$ 1995 1996

U n iv e rs ity o f Sydney cont.

Prof. M. Bennett Dr N. Lavidis Physiology

N eurom uscular transmission Standard Project starting in 1994 940625 51,058.99 Yes Yes

Prof. M. Bennett Dr N. Lavidis Physiology Sympathetic neurotransm ission Standard Project starting in 1994 940634 67,673.20 Yes Yes

A /Prof. N. Berend Thoracic Medicine Role of a bacterial factor in bronchitis Standard Project continued from 1992 920376· 31,436.66 No No

A /Prof. J. Black Dr C. A rm our Mr P. Johnson Pharmacology Airway smooth muscle in asthma Standard Project starting in 1994 940051 124,294.05 Yes Yes

Prof. R. Boakes Prof. M. Tattersall Psychology Comparisons of treatm ents for side-effects of chem otherapy for cancer patients Standard Project continued from 1992 920904 44,687.81 No No

Dr A. Brownlee Dr D. Ellis Prof. T. Sorrell

Animal H usbandry M olecular study of the distribution of cryptococcu neoformans Standard Project continued from 1993 931038 38,258.12 Yes No

82

REGKEY Future supoport

$ 1995 1996

U n iv e rs ity of S ydney cont.

Dr P. Bye Prof. C. Sullivan Respiratory M edicine New treatm ents to im prove breathing in chronic lung and chest w all disease Standard Project continued from 1992 920380 37,439.84 No No

Dr S. Carlile Physiology Processing of complex sounds by the nervous system

Standard Project starting in 1994 940610 51,973.16 Yes Yes

Dr T. Chan-Ling Prof. J. Stone Anatomy and Histology Developing a treatm ent for retinopathy of

prem aturity Standard Project starting in 1994 940011 90,807.17 Yes Yes

Dr H. Cheung Prof. M. Tattersall Dr M. Smal Pharmacy

Generating an anti-cancer drug at tum our sites Standard Project continued from 1992 920306 56,354.57 No No

Dr M. Christie Pharmacology Molecular mechanisms controlling excitability of mam m alian cells Standard Project continued from 1993 930621 44,745.48 Yes No

A /Prof. R. Christopherson Biochemistry Inhibitors of cell replication as potential anticancer drugs

Standard Project continued from 1992 920321 96,904.13 No No

A /Prof. R. Christopherson Biochemistry A new prim ary mechanism of action of the anticancer drug methotrexate Standard Project continued from 1993 930019 42,118.99 Yes No

83

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Future supoport 1995 1996

U n iv e rs ity of Sydney cont.

Dr C. Clarke Oncology Steroid horm one receptors in breast cancer Standard Project continued from 1993 930510 104,464.32 Yes Yes

Dr D. Cook Physiology Ion transport in early developm ent Standard Project continued from 1992 920722 41,536.98 No No

Dr D. Cook Prof. J. Young Physiology Sodium chloride transport by salivary ducts Standard Project starting in 1994 940682 45,425.44 Yes Yes

Prof. Y. Cossart Ms K. Vickery Dr C. Harbour Dr R. Givney Infectious Diseases Hepatitis b virus changes in response to vaccination Standard Project continued from 1993 930327 51,861.95 Yes No

Dr I. C urt hoys Dr G. Halmagyi Eye and Ear How the balance organs in the inner ear operate Standard Project continued from 1992 920205 44,740.79 No No

Dr I. Curthoys Psychology Does the balance system control the axis of eye rotation Standard Project starting in 1994 940615 49,898.90 Yes Yes

Dr R. Dampney Physiology Functions of brain cells controlling blood pressure Standard Project continued from 1991 910735 94,722.56 Yes No

84

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Future supoport 1995 1996

U n iv e rs ity of S ydney cont.

Dr G. Denyer Biochemistry How the insulin sensitivity of enzym es changes during obesity and NIDDM

Standard Project continued from 1992 920927 41,205.73 No No

A /Prof. C. Dos Remedies Anatomy and Histology How do the contractile proteins produce force Standard Project starting in 1994 940605 71,049.39 Yes Yes

Dr B. Dreher Prof. W. Burke Anatomy Organization of visual pathw ays in the brain

Standard Project continued from 1992 920705 41,313.67 No No

Prof. G. Farrell Medicine Liver enzymes and obstructed bile flow Standard Project continued from 1992 920341 42,770.79 No No

Prof. G. Farrell Gastroenterology How do drugs cause hepatitis and jaundice Standard Project starting in 1994 940027 79,955.34 Yes Yes

Dr M. Field Dr C. Pollock Medicine Regulation of kidney growth in disease

Standard Project continued from 1992 920249 58,574.59 No No

A /Prof. S. Freedman Dr R. Jeremy Dr G. Bautovich Mr S. Meikle

Cardiology Improving clot dissolving therapy for heart attack Standard Project starting in 1994 940013 45,998.28 Yes No

85

REGKEY $

Future supoport 1995 1996

U n iv e rs ity o f Sydney cont.

Dr J. Gready Biochemistry New anti-folates as selective anti-cancer drugs Standard Project continued from 1993 930025 47,777.27 Yes No

Dr J. Gready Biochemistry Development of a probe for pteridine actions in the im m une system Standard Project continued from 1993 930789 43,586.73 Yes No

Dr J. Gready Dr P. Cummins Biochemistry New drugs for cancer chem otherapy Standard Project starting in 1994 940616' 128,034.81 Yes Yes

Dr J. Guss Dr G. Cox Chem istry U nderstanding the conversion of foodstuffs into energy by all living cells Standard Project continued from 1993

Prof. A. Gyory Medicine Diuresis in health and disease Standard Project continued from 1992

Dr G. Halliday Dr J. Morris Dr R. Pamphlett Dr M. Hely Pathology Are motor symptoms linked to specific brain lesions in Parkinson's disease?

Standard Project continued from 1992 920390 76,824.91 No No

930037 42,118.99 Yes No

920377 75,651.39 No No

8 6

REGKEY

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Future supoport 1995 1996

U n iv e rs ity of S ydney cont.

Dr G. H alliday Dr G. O'Sullivan Prof. R. Barnet son Dermatology Regulation of the skin im m une system Standard Project continued from 1993 931068 51,819.65 Yes No

Dr G. H alliday Ms J. Kril Pathology Do only certain brain lesions cause m em ory loss?

Standard Project continued from 1993 931260 99,592.84 Yes Yes

Dr B. Ham bly Dr G. King Pathology A study of the molecular basis of muscle contraction

Standard Project continued from 1993 931130 46,161.38 Yes No

A /Prof. D. H andelsm an Dr E. Gorczynska Obstetrics/G ynaecology How horm ones and electrical properties govern

the function of sertoli cells Standard Project continued from 1993 930135 82,057.96 Yes No

A /Prof. D. H andelsm an Obstetrics/G ynaecology How horm ones control sperm production

Standard Project starting in 1994 940017 57,422.61 Yes Yes

Dr D. Henderson-Sm art Perinatal M edicine Breathing defences against asphyxia in babies Standard Project continued from 1992 920788 57,815.04 No No

Dr S. H odgkinson Medicine The m echanisms of nerve dam age in im m une neurological diseases

Standard Project starting in 1994 940528 33,048.31 Yes Yes

87

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Future supoport 1995 1996

U n iv e rs ity of Sydney cont.

D rJ.H o h Physiology Studies on cat jaw muscle genes Standard Project continued from 1993 931139 50,809.06 Yes No

A /Prof. G. Holder Prof. M. McManus Pharmacy How environmental cancer causing chemicals are processed by hum an enzymes Standard Project continued from 1993 930133 42,805.80 Yes No

Prof. N. Hunt Pathology What controls the grow th and m ultiplication of lymphocytes?

Standard Project continued from 1992 920314 56,402.50 No No

A /Prof. R. Kefford Dr P. Harnett Dr J. Donald Prof. W. McCarthy Medicine A search for the gene(s) responsible for melanoma Standard Project continued from 1992 920333 106,363.71 No No

A /Prof. J. Kellow Prof. C. Tennant Dr R. Hoschl Ms E. Bennett Medicine Emotional distress and normal and abnormal gastrointestinal function Standard Project starting in 1994 940028 35,888.28 Yes Yes

Dr G. King Dr A. Weiss Biochemistry A molecular study of protein dimerisation via 'leucine zippers' Standard Project continued from 1993 931044 45,635.47 Yes No

88

REGKEY Future supoport

$ 1995 1996

U n iv e rs ity of S ydney cont.

Prof. P. Kuchel Dr B. C hapm an Mr B. Bulliman Biochemistry

Functional characterisation of the hum an erythrocyte using NMR spectroscopy Standard Project starting in 1994 940931 114,361.18 Yes Yes

A /Prof. C. M artin Surgery A combined phyciological and anatomical study of gastro-oesophageal reflux in the dog

Standard Project continued from 1993 930050 36,758.00 Yes Yes

Dr P. Martin Prof. A. Sefton Physiology A study of colour and from vision in prim ates

Standard Project continued from 1993 931011 62,019.44 Yes No

Dr R. Mason Physiology Direct and indirect effects of estrogens in a hum an bone formation model Standard Project continued from 1992 920295 45,155.42 No No

Prof. L. M ather Prof. M. Cousins Dr C. Duke Anaesthesia

Left- and right-handed molecules — effects and fate in the body Standard Project starting in 1994 940784 55,884.39 Yes Yes

Dr J. McAvoy Dr C. Cham berlain Anatomy and Histology Effects of grow th factors on cultured lens cells:

implications for understanding cataract Standard Project starting in 1994 940602 69,201.09 Yes Yes

89

REGKEY

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Future supoport 1995 1996

U niversity of Sydney cont. Dr B. Morris Physiology Molecular mechanism of operation of an im portant cardiovascular control gene Standard Project starting in 1994 940606 44,034.31 Yes Yes

Dr C. Mountford Dr B. Kunnecke Prof. P. Russell Dr W. Hull Cancer Medicine Cancer pathology determ ined by magnetic resonance Standard Project starting in 1994 940584 39,284.43 Yes Yes

Dr M. M urray Medicine Pesticides that destroy liver enzymes involved in the breakdow n of drugs Standard Project continued from 1991 910592 144,515.94 Yes No

Dr M. M urray Medicine Vitamin a control of liver enzymes that metabolise drugs Standard Project starting in 1994 940607 41,630.35 Yes Yes

A /Prof. E. Mylecharane Dr H. Lloyd Pharmacology U nderstanding how new drugs can affect brain function related to schizophrenia Standard Project starting in 1994 940783 23,686.21 Yes Yes

Dr C. Nicholson Dr D. Ross Medicine Finding the gene for the commonest genetic disease of peripheral nerve Standard Project continued from 1991 910591 156,138.89 No No

90

REGKEY $

Future supoport 1995 1996

U n iv e rs ity o f S ydney cont.

Prof. R. Oates Dr B. O'Toole Paediatrics and Child Health M edium -term effects of child sexual abuse

Standard Project continued from 1992

Dr P. Penfold Dr J. Pro vis Prof. F. Billson Ophthalm ology

Im m une cells in the hum an retina Standard Project starting in 1994

Prof. A. Pettigrew Dr J. Freeman Veterinary Physiology Control of neuronal excitability

Standard Project continued from 1992

Dr W. Phillips Physiology Organisation of nerve to muscle signalling molecules

Standard Project starting in 1994

A /Prof. J. Pollard Medicine Mechanisms by which antibodies gain access to m yelinated nerve fibres Standard Project starting in 1994

920940 57,599.74 No No

940171 35,070.31 Yes Yes

920409 97,275.49 No No

940529 47,372.43 Yes Yes

940001 67,998.19 Yes Yes

Prof. B. Roufogalis Pharmacy The role of calcium in the properties of red blood cells

Standard Project continued from 1992 920118 108,837.20 No No

Dr P. Satchell Surgery Urine storage and the sym pathetic nervous system Standard Project continued from 1993 930026 40,970.35 No No

91

REGKEY $

Future supoport 1995 1996

U n iv e rs ity o f Sydney cont.

A /Prof. L. Schrieber Prof. B. Robinson Dr V. Hyland Rheumatology The mechanisms of inflam m ation in rheum atoid arthritis Standard Project continued from 1992 920346 44,969.75 No No

Prof. A. Sheil Dr G. Kelly Dr P. Healy Agriculture Prevention of inherited defects by foetal transplantation Standard Project continued from 1993 931043 56,448.84 Yes No

Prof. R. Skurray Microbiology N ature and evolution of antibiotic resistance in hospital staphylococci Standard Project continued from 1990 900225 91,835.83 No No

Prof. J. Stone Dr T. Chan-Ling Dr S. Tout Anatom y and Histology The formation m aturation and vascular function of the neuroglia of the retina Standard Project starting in 1994 940773 67,394.33 Yes Yes

Prof. C. Sullivan Medicine Effects of repeated falls of blood oxygen on breathing Standard Project continued from 1992 920315 74,574.30 No No

Prof. C. Sullivan Dr R. Grunstein Ms H. Bearpark Sleep disorders Effect of snoring and sleep apnoea on sleepiness and driving performance Standard Project continued from 1993 930342 43,762.05 No No

92

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Future supoport 1995 1996

U n iv e rs ity of S ydney cont.

Prof. C. Sullivan Dr I. Wilcox Dr R. Grunstein Prof. D. Kelly

Medicine Abnormal breathing during sleep in heart failure: causes, effects and response to treatm ent Standard Project continued from 1993 931028 92,770.06 Yes No

Prof. C. Tennant Dr J. Ungerer Prof. D. Saunders Ms J. Beaurepaire

Psychiatry IVF parents & children: a com parative study of cognitive developm ent & psychosocial adjust Standard Project starting in 1994 940684 51,991.99 Yes Yes

Dr R. Thompson A /Prof. B. Trudinger Obstetrics/Gynaecology Explanation of blood flow patterns in the unborn

fetus Standard Project continued from 1992 920089 53,031.52 Yes Yes

Prof. R. Trent Dr A. Smith Molecular Genetics Laboratory The genetics basis for obesity and m ental retardation

in the Prader Willi syndrome Standard Project continued from 1992 920303 163,654.26 Yes Yes

A /Prof. B. Trudinger Obstetrics/Gynaecology Why the placenta fails to nourish the baby before birth

Standard Project continued from 1992 920490 38,156.61 No No

I

93

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U n iv e rs ity of Sydney cont.

A /Prof. W. Webster Dr P. Brown-Woodman Dr A. Howe Anatomy The role of vitam in k in prenatal developm ent

Standard Project starting in 1994 940675 37,912.30 Yes Yes

Dr E. W hitelaw Biochemistry Designing vectors for the tissue-specific expression of genes in mammals Standard Project continued from 1993 931067 56,872.63 Yes No

Prof. A. Woolcock Dr E. Tovey Medicine -

The developm ent of house dust mite allergen avoidance strategies Standard Project continued from 1993 931277 91,753.35 Yes No

Prof. A. Woolcock Ms J. Peat Dr C. Mellis Prof. S. Leeder Medicine Role of allergens in asthm a Standard Project starting in 1994 940174 74,678.50 Yes Yes

University of Wollongong Dr M. Baker Biological Science Plasminogen receptors and breast cancer Standard Project starting in 1994 940857 51,798.08 Yes Yes

A /Prof. A. Hulbert Biological Science Factors influencing tissue tolerance of hypotherm ia Standard Project starting in 1994 941277 23,308.61 Yes Yes

Dr M. Walker Biology

The developm ent of a safer whooping cough vaccine Standard Project continued from 1993 930123 46,342.89 Yes No

94

REGKEY

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Future supoport 1995 1996

U n iv e rs ity of W o llo n g o n g cont.

Dr G. Wickham Dr 1. Radford Prof. D. Craik Pharmaceutical Chem istry

Novel D N A -dam aging agents as potential anticancer drugs Standard Project continued from 1992 920524 50,943.83 No No

Westmead H o s p ita l Dr R. Allen Dr ]. Chapm an A /Prof. G. Stewart

Prof. J. Little Surgery Towards transplantation of pig islets for treatm ent of Juvenile Diabetes

Standard Project continued from 1993

Dr T. Amis Dr J. Wheatley Respiratory Medicine Soft palate function during breathing Standard Project starting in 1994

Dr S. Boyages Prof. C. Eastman Dr P.J. Hal pern Endocrinology

Monitoring iodine deficiency disorders Standard Project continued from 1992

Dr K. Brad stock Haematology What controls the growth of acute leukaemia cells? Standard Project continued from 1992 920127 70,566.29 No No

A /Prof. A. Cunningham Virology Transmission of herpes simplex virus from neurone to epiderm al cell

Standard Project starting in 1994 940466 58,310.95 Yes Yes

931098 104,719.36 Yes No

940955 51,930.86 Yes Yes

920923 44,745.26 No No

95

RECKEY

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Future supoport 1995 1996

W estmead H o sp ita l cont.

Dr N. Dorsch Ms Y. Zurynski Dr Y. M udaliar Dr D. Farlow N eurosurgery Prediction of brain artery narrowing and outcome after severe head injury Standard Project starting in 1994 940858 21,256.41 Yes Yes

Dr E. Favaloro Haem atology How cell surface molecules help to prevent blood loss Standard Project continued from 1992 920630 29,203.72 No No

Dr E. Gordon .

Dr C. Latimer Dr R. Barry Psychiatry Eye m ovem ent patterns to faces in schizophrenia Standard Project starting in 1994 940485 34,110.03 Yes Yes

Dr D. Gottlieb H aem atology A ttachm ent of leukaemia cells to bone m arrow and how its reduction may help cure leukaemia Standard Project continued from 1992 920632 38,539.99 No No

Dr M. Hertzberg H aem atology Role of a clotting protein in the control of bleeding Standard Project starting in 1994 940401 39,710.56 Yes Yes

Prof. S. Feeder Dr A. Wilson Dr M. Gliksman Dr R. Lazarus Com m unity Medicine Causes of stroke in the elderly Standard Project continued from 1993 931167 12,499.68 Yes Yes

96

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Future supoport 1995 1996

Westmead H o s p ita l cont.

Prof. R. Meares Mr C. Rennie Neurosciences

Variability of brain electrical activity as a marker of schizophrenia Standard Project continued from 1992

Prof. R. Meares Dr R. Barry Psychiatry Nervous system dysfunction in a chronic pain disorder Standard Project continued from 1992

Prof. R. Meares Dr J. Stevenson Psychiatry A linguistic and economic study of outcome in severe personality disorder Standard Project continued from 1993

Dr D. Ross Cardiology New m ethod of treatm ent for dangerous

heart rhythm Standard Project continued from 1993

Dr D. Ross Dr A. Denniss Ms J. Hall Cardiology

Early return to normal activities after a heart attack Standard Project starting in 1994

Dr D. Ross Cardiology Com parison of Sotalol and Lignocaine for treatm ent of refractory cardiac arrest

Standard Project starting in 1994

920052 37,272.24 No No

920074 34,814.56 No No

930914 43,202.53 Yes No

930933 45,516.12 Yes No

940496 42,919.48 Yes Yes

940499 45,315.78 Yes Yes

97

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Future supoport 1995 1996

Westmead H o sp ita l cont.

A /Prof. G. Stewart Dr M. Ferrara Dr D. Anson Dr J. Hop wood Clinical Immunology Treatment of an inherited brain disease in dogs

by gene therapy Standard Project continued from 1993 931086 153,836.69 Yes No

Dr J. Wheatley Medicine Function of the throat and breathing muscles Standard Project continued from 1992 920200 84,407.13 No No

98

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___________________________________________________ $

Anti-Cancer Council

Dr G. Giles Dr M. McCredie Dr D. English Mr W. Johnson Cancer Research Unit W hy do som e m en get prostate cancer? Standard Project starting in 1994 940394

Austin Hospital Prof. G. Donnan A /Prof. S. Davis Dr B. Chambers

Dr E. Stewart-W ynne Neurology A ustralian study of a clot dissolving agent for acute stroke Standard Project continued from 1992 920033

Dr R. Sewell Dr R. Jones Medicine Kupffer cell function in liver transplantation

Standard Project starting in 1994 940450

Austin Hospital Medical Research Foundation Dr J. Wiley Dr P. Thurlow H aem atology Calcium signalling between endothelium and

lym phocytes Standard Project starting in 1994 940886

Alfred Hospital, Vic Dr F. Dudley Gastroenterology Study of the factors that contribute to fluid

retention in liver disease Standard Project continued from 1993 930231

Future supoport 1995 1996

105,312.87 Yes Yes

96,669.82 No No

36,172.06 Yes Yes

49,822.77 Yes Yes

26,726.54 Yes No

99

REGKEY Future supoport

$ 1995 1996

A ustin Research Institute Mr M. Smyth Medical Research Control of natural killer cell genes Standard Project starting in 1994 940490 53,074.87 Yes Yes

Dr J. Trapani Cellular Cytotoxicity Chemical mediators of cancer cell killing by killer lymphocytes Standard Project starting in 1994 940493 47,023.02 Yes Yes

Peter M acCallum Cancer Institute Dr I. Bertoncello Dr N. Williams Dr I. McNiece Cell Biology The action of a new blood grow th factor in

sustaining blood cell levels Standard Project continued from 1992 920037 62,545.01 No No

Dr I. Bertoncello Dr N. Williams Cell Biology The ability of blood-derives stem cells to sustain blood cell production Standard Project continued from 1993 931082 57,459.44 Yes No

A /Prof. N. Hacker Dr J. Campbell Dr C. Bull Dr J. Bishop Gynaecology Clinical trial of concurrent radiotherapy and chem otherapy for cancer of the cervix Standard Project continued from 1992 921138 29,118.13 No No

Dr M. Joschko Dr J. Bishop Dr L. Webster Dr D. Ball Experimental Chem otheraphy Unit Establishing the best schedule for giving drugs with radiotherapy Standard Project starting in 1994 940934 51,051.81 Yes No

100

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Future supoport 1995 1996

Peter M acC allum Cancer Institute cont. Dr R. M artin Dr R. Cooper Molecular Sciences Group

New drugs for cancer radiotherapy: basic studies of radiation and molecules Standard Project continued from 1992 920029 52,219.21 No No

Dr R. M artin Molecular Sciences Group Study of dam age caused by a single radioactive atom in a DNA molecule Standard Project continued from 1993

Dr J. Sambrook Oncology A transgenic model of ocular melanoma Standard Project starting in 1994

Dr D. Woodcock Molecular Genetics Laboratory H um an jum ping genes Standard Project starting in 1994

D eakin U niversity Dr G. Collier Prof. K. O'Dea Prof. P. Zimmet Nutrition Development of non-insulin-dependent diabetes m ellitus in the sand rat: a unique rodent model Standard Project starting in 1994 941171 40,295.43 Yes Yes

Dr I. Cooke Dr P. Berger Reproductive Medicine Development of the ability to breathe

Standard Project starting in 1994 940468 38,273.43 Yes Yes

Dr J. M uir Prof. K. O'Dea H um an N utrition Possible health benefits from undigested starch

Standard Project continued from 1992 920155 47,304.33 No No

930356 32,004.19 Yes No

940470 118,670.88 Yes Yes

940580 45,240.03 Yes Yes

101

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Future supoport 1995 1996

Dr J. M uir A /Prof. G. Young N utrition The effect of undigested starch on bowel function

and cancer Standard Project starting in 1994 940461 44,987.28 Yes Yes

La Trobe University Prof. C. Bernard Psychology Role of autoim m une t cells in multiple sclerosis Standard Project continued from 1993 931145 52,224.95 Yes No

Mr M. Fryer Dr D. Stephenson Zoology Calcium cycling within muscle cells .

Standard Project starting in 1994 940887 46,259.30 Yes Yes

Dr J. Graves Dr M. Schmidt Genetics and Hum an Variation H um an genetic disease caused by abnormal X chromosome control Standard Project continued from 1992 920018 73,947.74 No No

Dr J. Graves Genetics and Hum an Variation How is sex determ ined in man and other animals?

Standard Project continued from 1992 920523 51,857.19 No No

Dr J. Graves Genetics and Human Variation Why do genes passed from the mother or father have different effects?

Standard Project starting in 1994 940894 77,612.51 Yes Yes

Dr J. Graves Genetics and Human Variation A search for im portant new genes involved in sexual differentiation Standard Project starting in 1994 940895 58,017.60 Yes Yes

1 0 2

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Future supoport 1995 1996

La Trobe U niversity cont. Dr S. Head Dr D. Stephenson Zoology How m uscular dystrophy affects the structure and function of muscle Standard Project continued from 1993 930495 56,408.59 Yes No

Dr P. Hoj Prof. N. Hoogenraad Biochemistry The role of protein folding catalysts in cells

under stress Standard Project continued from 1993 931127 54,851.44 Yes No

Dr N. Kerlero de Rosbo Prof. C. Bernard Psychology Im m une responses in a new m odel of m ultiple sclerosis Standard Project starting in 1994 940454 93,570.78 Yes Yes

Dr G. Lamb Dr D. Stephenson Zoology Control of contraction in normal m uscle and in dystrophic myscle. Standard Project continued from 1991 911070 101,554.88 Yes No

Dr D. Loesch Dr I. H udson Dr D. Hay Psychology

Grow th study in normal children and in genetic abnorm ality 'fragile X' Standard Project continued from 1991 911072 110,341.99 Yes No

Prof. M. Prior Dr A. Sanson Dr F. Oberklaid Prof. G. Bowes

Psychology Psychosocial adjustm ent across the early adolescence transition period

Standard Project starting in 1994 940381 55,212.73 Yes Yes

103

REGKEY

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Future supoport 1995 1996

La Trobe U niversity cont. Dr G. Stephenson Dr D. Stephenson Zoology

H orm one action on heart and skeletal muscle contraction Standard Project continued from 1991 910410 47,528.49 No No

Dr L. Tilley Biochemistry N ew drugs to combat malaria Standard Project continued from 1992 920543 51,192.44 No No

Dr L. Tilley Dr L. Deady Biochemistry Antimalarial drugs — mechanisms of action and .

resistance Standard Project continued from 1993

L udw ig Institute for Cancer Research Dr G. Baldwin Epithelial Biology Group

Signalling m echanisms of the hormone gastrin Standard Project continued from 1992

Dr G. Baldwin Biochemistry Signalling mechanisms of the hormone gastrin Standard Project starting in 1994

Prof. A. Burgess Dr E. Nice Epithelial Biology Group Designing inhibitors for cancer cells Standard Project continued from 1992

Dr A. Dunn M olecular Biology Laboratory The role of the SRC-related molecule, hck, in the developing embryo and blood cells Standard Project starting in 1994 940918 43,752.39 Yes Yes

930481 44,745.48 Yes No

920527 49,909.99 No No

940924 101,713.42 Yes Yes

920525 47,408.76 No No

104

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$

Future supoport 1995 1996

Ludw ig In stitu te for Cancer Research cont. Dr H. M aruta Prof. A. Burgess Tumour Cell Biology

Developm ent of anti-cancer reagents that counteract oncogenic ras genes Standard Project continued from 1992 920025 52,494.58 No No

Dr R. Ramsay Dr A. Dunn Molecular Biology Laboratory Studies of mice w ith a cancer gene that affects blood and colon cells Standard Project starting in 1994 940936 54,220.36 Yes Yes

Dr R. Simpson Dr L. Ward Dr A. Ham m acher Protein Chem istry Laboratory Characterisation of a protein involved in

lym phoid cancer Standard Project continued from 1992 920528 49,393.06 No No

Dr R. W hitehead Dr J. Joseph Cancer Research The im m ortalisation of hum an colonic mucosal epithelial crypt cells

Standard Project starting in 1994 940397 48,765.08 Yes Yes

Dr A. Wilks Dr A. Gabriel Growth Regulation A model for hum an colon cancer

Standard Project continued from 1993 930160 46,766.67 Yes No

Dr A. Wilks Growth Regulation Role of a new class of proteins in normal and

cancerous growth Standard Project continued from 1993 930228 36,236.93 Yes No

I

105

REGKEY Future supoport

__________________________________________________________ $____________ 1995 1996

M acfarlane B um et Centre for M edical Research Dr D. Bowden Mr T. Shaw Dr S. Locarnini H epatitis Research New treatments for chronic hepatitis B virus infection Standard Project continued from 1992 920841 48,442.60 No No

Prof. J. Mills Dr J. Meanger Dr J. Gorman Virology Characterisation and identification of the cell receptor for respiratory syncytial virus Standard Project starting in 1994 940706 98,869.08 Yes Yes

Mental Health Research Institute of Victoria .

Dr A. Lim Neuroendocrinology N eurotransm itter m odulation of striatial and hypothalm ic neurons Standard Project continued from 1993 930807 100,156.69 Yes No

M onash University Prof. D. de Kretser Dr M. H edger Dr N. Wreford Reproductive Medicine Local factors involved in controlling spermatogenesis Standard Project continued from 1993 930925 72,516.91 Yes No

Prof. D. de Kretser Dr G. Jenkin Reproductive Medicine The role of inhibin and related proteins in

gonadal developm ent Standard Project continued from 1993 930941 48,001.07 Yes No

Dr B. Adler Microbiology How shigella bacteria cause dysentery Standard Project starting in 1994 940941 60,912.71 Yes Yes

1 0 6

REGKEY $

Future supoport 1995 1996

M onash U niversity cont. Dr C. Barclay Prof. C. Gibbs Physiology

Does the high metabolic cost of w ork increase skeletal muscle fatigue? Standard Project starting in 1994 940939 14,305.65 Yes No

Dr P. Beart Pharmacology Receptors in brain for glutamate, the major excitatory transm itter Standard Project continued from 1992 920398 136,767.97 Yes Yes

Dr P. Beart Pharmacology Brain cholecystokinin receptors: interfaces with

classical transm itters Standard Project starting in 1994 940937 50,699.46 Yes Yes

Dr P. Berger Reproductive Medicine Im provem ent of breathing after birth due to labour Standard Project starting in 1994 940487 106,113.89 Yes Yes

Dr P. Bird Dr W. Hancock Prof. H. Salem Medicine

In vivo and in vitro studies of throm bom odulin m odular regulation Standard Project starting in 1994 940926 112,151.73 Yes Yes

Dr D. Bowden Anatomy A study of possible protection against m alaria by some com m on inherited blood disorders Standard Project starting in 1994 941000 54,086.28 Yes Yes

Dr R. Boyd Pathology and Immunology How does the thym us produce T lym phocytes Standard Project continued from 1993 930433 60,915.01 Yes No

107

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Future supoport 1995 1996

M onash U niversity cont. Dr R. Boyd Pathology and Immunology Intrathym ic selection mechanisms Standard Project starting in 1994 940590 85,798.57 Yes Yes

A /Prof. R. By water Dr D. Lyster A /Prof. G. Taylor Physiology Development of the nerves and muscles in the large bowel Standard Project continued from 1992 920994 46,394.93 No No

Dr B. Canny Physiology The control of horm one secretion from single cells .

Standard Project continued from 1993 930424 40,973.60 Yes No

Dr F. Carbone Pathology and Immunology The elimination of T lym phocytes that attack self tissues Standard Project continued from 1992 921039 49,105.10 No No

Dr F. Carbone Pathology and Immunology The stucture of the molecules involved in T lym phocyte recognition Standard Project continued from 1993 930425 52,830.25 Yes No

Dr D. Clarke Prof. G. Smith Prof. H. Flerrman Mr D. McKenzie Psychological Medicine Psychological problems in the severely medically ill Standard Project continued from 1992 920493 64,516.58 No No

Dr H. Coleman Prof M. Holman Physiology Ion channels allowing calcium influx in smooth muscle

Standard Project starting in 1994 940998 63,615.41 Yes Yes

108

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Future supoport 1995 1996

M onash U niversity cont. Dr W. Com per A /Prof. E. Glasgow Biochemistry

Kidney filtration Standard Project starting in 1994

Dr H. Critchley Dr P. Rogers Prof. D. Healy O bstetrics/Gynaecology Study of uterine lining in wom en w ith excessive

m enstrual blood loss Standard Project continued from 1993

Dr J. Davies Microbiology Assembly of adhesive structures on bacterial cell surfaces

Standard Project continued from 1993

Dr M. Dziadek Centre for Early Human Development Development of the blood-brain barrier Standard Project continued from 1992

Dr M. Dziadek Dr M. Overall Prof. A. Trounson

Centre for Early Human Development Genetic control of mouse developm ent Standard Project continued from 1993

Prof. C. Gibbs Dr I. Wendt Physiology Muscle mechanics and metabolism Standard Project continued from 1992

Dr P. Gleeson Pathology and Immunology Characterisation of cellular signals for protein sorting and secretion

Standard Project starting in 1994

941009 49,871.62 Yes Yes

930284 63,143.79 Yes No

930272 63,172.34 Yes No

920484 83,922.11 No No

930949 66,634.08 Yes No

920489 84,387.33 Yes Yes

940878 71,803.41 Yes Yes

109

RECKEY

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Future supoport 1995 1996

M onash U niversity cont. Prof. J. Coding Ms J. Favaloro Pathology and Immunology M embrane proteins of antibody-secreting cells Standard Project starting in 1994 940871 48,807.39 Yes Yes

Dr W. Hancock Pathology and Immunology Effects of anticoagulant proteins on inflammation and transplant rejection Standard Project continued from 1993 930390 74,348.33 Yes No

Dr C. Handley Dr H. Robinson Biochemistry Degradation of cartilage in joint disease .

Standard Project continued from 1992 920990 58,125.79 No No

Dr C. Handley Dr M. Campbell Biochemistry Ligaments and synovial capsule in health and disease Standard Project continued from 1993

Dr C. Handley Dr H. Robinson Dr J. Underwood Biochemistry Sulphite production by inflammatory cells Standard Project starting in 1994

Dr R. Harding Physiology Control of lung development in the fetus Standard Project continued from 1990

Dr Ma Hedger Prof. D. de Kretser Reproductive Medicine Functions of the testicular macrophage Standard Project starting in 1994

930985 77,234.95 Yes No

940409 66,909.50 Yes Yes

900348 116,841.59 No No

940879 40,849.80 Yes Yes

n o

REGKEY $

Future supoport 1995 1996

Monash University cont. Dr P. H ertzog Dr M. Tymms Dr I. Kola Centre for Early H um an D evelopm ent

The im portance of interferons in normal developm ent and in dow n syndrom e Standard Project continued from 1993 930398 95,715.86 Yes No

Dr S. H ooper Prof. G. Thorburn Dr R. Harding Physiology Effect of prolonged periods of oxygen lack on metabolism in the fetus Standard Project continued from 1993 931101 37,247.53 Yes No

Dr M. Horne Anatom y Control of sim ple movements Standard Project continued from 1992 921026 96,853.34 No No

Dr M. Horne Dr R. Iansek Anatomy A study of how the basal ganglia and supplem entary m otor area communicate Standard Project starting in 1994 940866 58,875.08 Yes Yes

Dr D. Irvine Dr R. Rajan Psychology Effects of partial deafness on the organization of

brain auditory pathw ays Standard Project continued from 1992 920483 43,242.21 Yes Yes

Dr S. Jane Prof. H. Salem Medicine Investigation of protein involved in the regulation of the hem oglobin genes Standard Project starting in 1994 940573 47,018.98 Yes Yes

111

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Future supoport 1995 1996

Monash University cont. Prof. B. Jarrott Medicine How local horm ones alter nerve transmission in the kidneys Standard Project continued from 1992 920838 42,902.06 No No

Prof. B. Jarrott Medicine How the brain senses the level of blood pressure Standard Project continued from 1992 920839 60,192.36 No No

Prof. B. Jarrott Dr R. Widdop Pharmacology How the brain controls the level of blood pressure Standard Project continued from 1993 931072· 3,673.52 Yes No

Dr R. King Mr M. Harris A /Prof. J. Lambert Prof. P. Rossiter Pharmacology Development of a m iniature microscope to view living tissue inside the body Standard Project continued from 1993 930376 39,087.21 Yes No

A /Prof. N. King Prof. B. Tonge Child Psychiatry

Evaluation of various psychological treatments for school-refusing children Standard Project starting in 1994 940572 18,429.01 Yes Yes

Dr I. Kola Dr M. Tymms Dr R. Anderson Dr V. Bolton Centre for Early H um an Development Study of a novel hum an HSP 70 gene Standard Project continued from 1992 920991 74,184.15 No No

112

REGKEY Future supoport

$ 1995 1996

M onash U niversity cont. Dr R. Lang Prof. M. Holman Physiology Studies of the m echanisms by which nerve

stim ulation controls blood vessels Standard Project continued from 1991 910542 68,656.85 Yes No

Dr J. McFarlane Dr G. Risbridger Reproductive Medicine Control of male sex horm one secretion Standard Project continued from 1993 930413 48,787.86 Yes No

A /Prof. B. McGrath Medicine Regulation of blood flow to the kidney and sodium excretion in heart failure Standard Project continued from 1993 930404 113,504.51 Yes No

Prof. J. McNeil A /Prof. B. McGrath Social and Preventative Medicine A study to determ ine w hether certain vitamins

can slow the progression of atherosclerosis Standard Project starting in 1994 940862 77,441.04 Yes Yes

Dr R. Med calf Medicine Regulation of the breakdown of blood clots Standard Project starting in 1994 940415 57,380.30 Yes Yes

Dr C. Mitchell Medicine Investigation of a novel enzyme regulating platelet function

Standard Project continued from 1993 930948 38,258.12 Yes No

Dr D. Morgan Dr U. Proske Electrical Engineering

How does training reduce the risk of injury from eccentric exercise Standard Project starting in 1994 940413 38,273.43 Yes Yes

113

REGKEY

$

Future supoport 1995 1996

M onash U niversity cont. Prof. P. O'Brien Dr F. Andrews Surgery How reducing blood flow to the stomach causes injury Standard Project continued from 1992 921017 33,889.32 No No

Dr H. Parkington Physiology Regulation of uterine activity by hormones Standard Project continued from 1993 930360 31,350.53 Yes No

Dr U. Proske Dr J. Gregory Physiology How sensory nerve endings in muscles contribute to the control of movement Standard Project starting in 1994 940593 120,329.22 Yes Yes

Dr R. Rajan Psychology Mechanisms shaping the responses of brain cells to sounds Standard Project starting in 1994 941006 94,515.79 Yes Yes

Dr S. Ralph Dr R. Devenish Prof. A. Linnane Dr K. Krauer Biochemistry Interferons, epstein barr virus and hum an cancer Standard Project starting in 1994 941001 68,682.34 Yes Yes

Dr C. Ramsden Paediatrics How the am ount of liquid in the lung is controlled Standard Project continued from 1992 921064 43,087.74 No No

Dr G. Rice Prof. S. Brennecke Prof. G. Thorburn Physiology Mechanisms controlling the onset of labour Standard Project continued from 1992 921028 109,906.18 Yes Yes

1 1 4

REGKEY

$

Future supoport 1995 1996

M onash U niversity cont. Dr G. Risbridger Reproductive M edicine Development and control of cells in the testis which produce male horm ones Standard Project continued from 1992 921042 115,641.95 Yes Yes

Dr P. Rogers O bstetrics/G ynaecology Factors that control the growth of new blood vessels in the uterus

Standard Project continued from 1993 930573 68,817.92 Yes Yes

Dr J. Rood Microbiology Evolution of genes which are from anaerobic disease causing bacteria and which confer resi Standard Project continued from 1993

Dr J. Rood Microbiology Role of bacterial toxins in gas gangrene Standard Project starting in 1994

Prof. H. Salem Dr P. Coughlin Dr R. Medcalf Dr P. Bird

Medicine Studies on a new protein involved in the regulation of blood clotting Standard Project continued from 1993 930323 60,403.26 Yes No

Dr J. Shaw Dr D. Macfarlane Dr A. Sathananthan Prof. A. Trounson

Centre for Early H um an Development Preservation of eggs by freezing Standard Project continued from 1992 920727 59,456.09 No No

931119 47,777.27 Yes No

941117 59,783.10 Yes Yes

115

REGKEY Future supoport

$ 1995 1996

M onash U niversity cont. Dr J. Smolich Centre for Early H um an Development Regulation of blood pressure and blood flow

before and after birth Standard Project continued from 1992 920736 46,891.84 No No

A /Prof. G. Taylor Dr R. Lang A /Prof. R. Bywater Physiology Mechanisms controlling spontaneous movements of the gut Standard Project continued from 1991 910529 25,509.90 No No

A /Prof. G. Taylor A /Prof. R. By water ·

Physiology Chemicals that alter gut movements Standard Project continued from 1992 920223 7,030.11 No No

Prof. G. Thorburn Physiology Is the fetus anaesthetized? Standard Project starting in 1994 940388 86,144.80 Yes Yes

Dr A. Tilbrook Prof. D. de Kretser A /Prof. I. Clarke Reproductive Medicine Hormonal interactions between the pituitary and testis Standard Project continued from 1992 920740 76,528.14 No No

Dr P. Tipping Prof. S. Holdsworth Medicine Control of anti-clotting mechanisms in glomerulonephritis Standard Project continued from 1992 920749 65,414.24 No No

116

REGKEY

$

Future supoport 1995 1996

M onash U niversity cont. Dr P. Tipping Prof. S. H oldsw orth Medicine

M echanisms of kidney dam age in severe nephritis Standard Project starting in 1994 940389 109,107.89 Yes Yes

Dr B. Toh Pathology and Immunology Role of blood lymphocytes in the autoim m une destruction of the stomach lining Standard Project continued from 1992

Dr B. Toh Dr P. Gleeson Dr I. Van Driel Pathology and Immunology

A new model for autoim m une disease Standard Project starting in 1994

Dr M. Tymms Dr P. H ertzog Dr 1. Kola Centre for Early H um an Development

Ets2 and erg genes in dow n syndrom e Standard Project continued from 1993

Dr J. U nderw ood Dr 1. Cosic Prof. M. Hearn Bioprocess Technology

Inhibition of tum our vascularization by synthetic peptides Standard Project continued from 1992

920798 48,442.60 No No

940853 116,451.73 Yes Yes

930932 57,526.39 Yes No

920304 52,206.62 No No

Dr I. Van Driel Pathology and Immunology Control of acid production in stomach and kidney Standard Project starting in 1994 940595 49,860.70 Yes Yes

Dr D. Walker Physiology Control of sleep and breathing movem ents before birth Standard Project continued from 1990 900326 110,409.97 No No

117

REGKEY $

Future supoport 1995 1996

M onash U niversity cont. A /Prof. A. Walker A /Prof. V. Yu Centre for Early Hum an Development Study of factors causing brain injury in preterm babies Standard Project continued from 1992

A /Prof. A. Walker Centre for Early H um an Development Development of fetal heart function from m id-pregnancy Standard Project continued from 1992

Dr D. Walker Dr A. Luff Physiology Factors which influence muscle development Standard Project continued from 1993

Prof. E. Walters Medicine Characterization of asthm a disease status by airw ay lymphocyte soluble factors Standard Project starting in 1994

Dr I. Wendt Dr G. Kotsanas Physiology How smooth muscles relax Standard Project continued from 1993

Dr L. Wise Psychology Neural coding of auditory motion in the cat m idbrain

Standard Project starting in 1994

920281 81,249.44 No No

920336 127,361.11 Yes Yes

930278 44,321.70 Yes No

940568 53,378.61 Yes Yes

930276 45,112.22 Yes No

940435 23,180.71 Yes No

Dr P. Wright Microbiology Replication of the genes of dengue and related viruses Standard Project continued from 1992 921116 71,702.54 No No

118

REGKEY Future supoport

1995 1996 $

N ational Research Institute of G erontology & Geriatic M edicine Dr Z. Khalil Research Studies of neurogenic inflam m ation in rat skin Standard Project continued from 1993 930611 38,076.61 Yes No

N ational V ision Research In stitu te of A ustralia Prof. R. A ugusteyn Biochemistry M aintaining the health of the eye

Standard Project continued from 1992 920459 43,087.74 No No

Prof. R. A ugusteyn Dr G. Smith Dr B. Pierscionek Research

Factors which influence the focussing capacity of the eye lens Standard Project continued from 1992 921040 18,553.08 No No

Prince H enry's Institute of M edical Research Prof. R. Atkins Nephrology

Treatment of glom erulonephritis w ith a cytokine antagonist Standard Project continued from 1993 930827 65,704.10 Yes No

Prof. R. Atkins Dr D. Nikolic-Paterson Dr P. Hill N ephrology

M echanisms by which white blood cells enter the kidney in progressive kidney disease Standard Project starting in 1994 940509 81,328.00 Yes Yes

Dr C. Chen A /Prof. I. Clarke Pharmacology M olecular m echanism of the control of growth

horm one secretion Standard Project continued from 1992 920245 51,080.96 No No

119

REGKEY Future supoport

__________________________________________________________ $_____________1995 1996

Prince Henry's Institute of Medical Research cont. A /Prof. I. Clarke Medical Research Brain control of reproduction Standard Project starting in 1994

Dr P. Fuller Endocrinology Determination of the structure of steroid horm one receptors Standard Project continued from 1992

Dr P. Fuller Medical Research Actions of adrenal steroids in the gut Standard Project continued from 1993

Dr H. Majcwski Medical Research Mechanisms of alterations of nerve activity by drugs Standard Project starting in 1994

Dr H. Majcwski Mrs M. Rcchtman Pharmacology Non cyclic AMP actions of milrinone Standard Project starting in 1994

Dr L. Salamonsen Biochemistry How the uterine lining is prepared for the im planting embryo Standard Project continued from 1992

Dr L. Salamonsen Research Local regulation of tissue breakdown in m enstruation Standard Project starting in 1994

940994 162,213.79 Yes Yes

920246 49,914.47 No No

930686 121,088.16 Yes Yes

940995 158,491.05 Yes Yes

941005 48,811.77 Yes No

920177 50,294.01 No No

940538 93,772.22 Yes Yes

120

REG KEY Future supoport

__________________________________________________________ $_____________1995 1996

Royal Children's Hospital Research Foundation Dr R. Bishop Dr G. Barnes Dr B. Coulson Gastroenterology

Rotavirus diarrhoea in young children Standard Project starting in 1994

Dr B. Coulson Dr R. Bishop Gastroenterology Parts of hum an rotavirus and target cells

im portant in protection against disease Standard Project starting in 1994

Dr A. H erington Ms S. Ymer Clinical Biochemistry Studies on the m echanisms for delivery and

action of grow th horm one Standard Project continued from 1992 920522 84,124.29 No No

Dr G. K annourakis Prof. H. Ekert H aem atology Studies on the causation of the childhood

histiocytic disorders Standard Project continued from 1992 920068 46,810.70 No No

Dr T. Nolan Ms B. Parry-Fielder Dr K. Collins Mr J. Fisher

Epidemiology The association betw een epilepsy and communication disorders in children

Standard Project starting in 1994 940432 37,097.39 Yes Yes

Ms E. N ortham Prof. R. Adler Diabetes and Endocrinology Cognitive functioning in children with diabetes Standard Project continued from 1992 920030 36,193.37 No No

940302 198,119.33 Yes Yes

940315 80,888.31 Yes Yes

121

RECKEY $

Future supoport 1995 1996

Royal Children's Hospital Research Foundation cont. Dr P. Robinson Thoracic Medicine The effect of cigarette smoke on virus infections of the lower airways Standard Project starting in 1994 940809 44,220.03 Yes Yes

Dr A. Sinclair Genetics The role of the testis determ ining gene in sex determination Standard Project continued from 1992 920316 65,422.05 No No

Dr G. Warnc Dr J. Zajac Endocrinology Novel aspects of male horm one action .

Standard Project starting in 1994 940813 42,198.03 Yes Yes

Royal Melbourne Hospital Dr G. Begley Haematology Mechanisms involved in the normal development of blood cells Standard Project continued from 1993 930605 52,559.75 Yes No

Dr G. Begley Dr A. Crigg Haematology Analysis of blood stem cells Standard Project starting in 1994 940805 47,081.36 Yes Yes

Dr P. Colman Endocrinology New m ethods for prediction of insulin-dependent diabetes

Standard Project starting in 1994 940444 68,229.56 Yes Yes

Prof. R. Fox Haematology Structure of the switch for a gene controlling cancer cell growth Standard Project continued from 1993 930813 40,159.96 Yes No

1 2 2

Royal Women's Hospital, Melbourne Prof. S. Brennecke Mr N. G ude Dr R. King

Perinatal M edicine H um an placental nitric oxide synthase Standard Project continued from 1993

A /Prof. L. Doyle Dr A. Watkins A /Prof. V. Yu Dr P. McDougall

Paediatrics Outcome for infants <1000g at birth in Victoria Standard Project continued from 1993

St. Vincent's Hospital, Melbourne Dr A. D'Apice Dr M. Pearse Clinical Im m unology Organ transplants between different species Standard Project starting in 1994

Mr A. Macleod Mr B. O'Brien Dr C. G urusinghe Microsurgery Transfer of rat knee joints with drug

im m unosuppression Standard Project continued from 1993

Prof. W. Morrison Prof. J. Hurley Mr B. O'Brien M icrosurgery Research Unit

Blood vessel grow th promoters in skin grafts with separate blood supply Standard Project continued from 1993

Dr D. Power Dr M. Pearse Clinical Im m unology M echanisms of kidney disease

Standard Project continued from 1993

REGKEY Future supoport

$ 1995 1996

930410 43,262.27 Yes No

930010 37,646.61 Yes No

940764 34,382.80 Yes Yes

930757 40,560.12 No No

930120 51,469.45 No No

930176 40,432.60 Yes No

123

REGKEY Future supoport

__________________________________________________________ $_____________1995 1996

Dr A. Stewart M icrosurgery Research Unit Chemicals that cause thickening of the airw ay tubes in asthma Standard Project continued from 1993 930777 99,586.44 Yes Yes

St. Vincent's Institute of Medical Research Dr D. Campbell Prof. A. Doyle Research H orm ones and blood pressure Standard Project continued from 1991

Dr D. Campbell Research H orm ones and blood pressure Standard Project continued from 1993

Prof. B. Kemp Biochemistry Enzymes that regulate the body's cells Standard Project continued from 1992

Prof. B. Kemp Dr P. Poumbourios Dr D. McPhee Research Structure of aids virus coat proteins Standard Project continued from 1993

Dr M. Parker Medicine Three-dimensional structures of medically-im portant proteins Standard Project starting in 1994

Dr P. Sexton Neurobiology The neurobiology of calcitonin Standard Project starting in 1994

910097 116,191.55 Yes No

930812· 38,411.41 Yes No

920004 193,238.40 Yes Yes

930169 86,603.69 Yes No

940402 93,799.81 Yes Yes

940855 46,242.03 Yes Yes

124

REGKEY Future supoport

1995 1996 $

Swinburne University Prof. R. Silberstein Prof. J. Wright Dr A. Sergejew Neurophysiology Laboratory Brain dynam ics of schizophrenia Standard Project starting in 1994 940489 61,281.82 Yes Yes

University of Melbourne A /Prof. D. Alcorn Dr P. Harris Prof. G. Ryan

Anatomy Development of structure and function of the renal m edulla Standard Project starting in 1994 940095 42,317.43 Yes Yes

Dr G. Aldred Prof. F. M endelsohn Medicine Studies on blood pressure regulation

Standard Project starting in 1994 940129 57,549.41 Yes Yes

Dr E. Anders Prof. D. White Microbiology How sugar-binding proteins contribute to

defence against virus infections

D rH . Baker Dr D. Liu O bstetrics/Gynaecology Investigating sperm abnormalities causing failure

of fertilization in vitro Standard Project continued from 1993 930628 35,227.34 Yes No

Dr J. Bateman Paediatrics Connective tissue structure and function Standard Project continued from 1992 920993 211,571.21 Yes Yes

Standard Project starting in 1994 940742 97,040.62 Yes Yes

125

REGKEY

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Future supoport 1995 1996

University of Melbourne cont. Dr J. Bateman Paediatrics Causes of brittle bones and abnormal tissue developm ent in childhood Standard Project continued from 1992 921125 83,922.11 Yes Yes

Dr J. Bertram A /Prof. D. Alcorn Dr V. Nurcombe Anatomy The role of specific molecules in kidney developm ent Standard Project continued from 1993 930633 47,353.48 Yes No

Dr P. Blarney Prof. G. Clark Dr G. Dooley ·

Otolaryngology Combining acoustic and electric sounds for hearing-impaired people Standard Project continued from 1993 930068 52,769.33 Yes Yes

Dr P. Blarney Prof. G. Clark Dr R. Cowan Mrs P. Dawson Otolaryngology Development of speech perception in children with impaired hearing Standard Project continued from 1993 930682 50,470.48 Yes Yes

Dr L. Brown Dr D. Jackson Prof. D. White Microbiology Will Synthetic T cell determ inants be a useful com ponent of influenza vaccines? Standard Project continued from 1993 930146 66,090.66 Yes Yes

Prof. E. Byrne Dr B. Jean-Francois Neurosciences Defective energy generation in human disease Standard Project starting in 1994 940206 75,526.60 Yes Yes

126

REGKEY $

Future supoport 1995 1996

University of Melbourne cont. Prof. R. Cahill Veterinary Science How cells of the im m une system recognize blood

vessel walls Standard Project continued from 1992 920822 60,423.97 No No

Dr J. Camakaris Genetics M echanism of copper transport in m am m alian cells

Standard Project starting in 1994 940082 55,884.39 Yes Yes

Dr C. Cheers Microbiology Chemical m ediators produced in response to vaccination Standard Project continued from 1992

Dr H. Cheng Biochemistry Src-family tyrosine kinases and CSK Standard Project starting in 1994

Dr M. Ching Prof. R. Smallwood Medicine How drug metabolising enzymes work

Standard Project continued from 1993

Dr T. Cocks Pharmacology Novel endogenous factors that control blood flow and the heart

Standard Project starting in 1994 940157 139,103.89 Yes Yes

Dr W. Cook Prof. G. Clunie Surgery The mechanisms of carcinogenesis by one class

of oncogenes Standard Project continued from 1990 900774 105,494.32 No No

921126 69,624.99 No No

940665 46,361.43 Yes Yes

930634 35,035.98 Yes No

127

REGKEY $

Future supoport 1995 1996

University of Melbourne cont. Dr M. Cooper Dr S. Skinner Medicine Hormones and diabetic complications Standard Project continued from 1993 930630 50,845.17 Yes No

Dr R. Cowan Prof. G. Clark Dr P. Blarney Otolaryngology Tickle talker — electrotactile aid for the deaf Standard Project continued from 1993 930675 40,184.42 Yes No

Prof. I. Darian-Smith Miss M. Galea Anatom y <

Form and function of neurons of the cerebral cortex that control movement Standard Project continued from 1993 930054 94,767.74 Yes No

A /Prof. S. Davis Prof. G. Donnan Dr M. Lichtenstein A /Prof. R. Moulds Neurology Stroke therapy and brain perfusion Standard Project starting in 1994 940741 35,888.28 Yes Yes

Dr P. Desmond Dr K. Watson Dr M. Mashford Medicine Studies on the way drugs are handled in patients with liver disease Standard Project continued from 1992 921113 42,902.06 No No

Prof. G. Donnan Dr A. Hughes Medicine Neurochemical causes of therapeutic failure in Parkinson's disease Standard Project continued from 1993 930045 47,819.57 Yes No

128

University of Melbourne cont. Dr G. Dusting Medical Research Potential new drugs for heart attacks, stroke and blocked arteries Standard Project starting in 1994

D r], Fraser Prof. V. Studdert Prof. R. Cahill Veterinary Science

Links between a novel disease of childhood and the shar-pei dog Standard Project starting in 1994

Dr M. Gething Biochemistry Protein folding in the cell Standard Project starting in 1994

Dr P. Gibson Medicine M aturation and cancer form ation in cells lining the colon and butyrate

Standard Project continued from 1992

Dr P. Gibson Medicine Urokinase and the lining of the large bowel Standard Project continued from 1993

A /Prof. A. Goodwin Anatomy Cortical mechanism s of hand function Standard Project continued from 1993

REGKEY Future supoport

$ 1995 1996

940074 73,652.01 Yes Yes

940673 94,284.20 Yes Yes

940662 115,431.13 Yes Yes

920785 47,223.09 No No

930660 39,268.72 Yes No

930626 98,738.55 Yes No

Dr A. Gundlach Prof. W. Louis Clinical Pharmacology Role of brain neuropeptides in cardiovascular control

Standard Project continued from 1992 920938 143,295.31 Yes Yes

129

REGKEY Future supoport

$ 1995 1996

University of Melbourne cont. Prof. K. Hardy Surgery Liver protection during surgery with absence of blood flow Standard Project continued from 1993 930641 26,213.56 Yes No

Dr S. Harrap Dr M. Kapuscinski Medicine Genetics of hypertension Standard Project starting in 1994 940194 34,334.36 Yes No

Dr P. Harris Dr S. Skinner Prof. F. Mendelsohn Physiology ·

How do kidney horm ones control kidney function? Standard Project continued from 1992 920269 79,440.66 No No

Dr P. Harris Dr E. Eitle Physiology Abnormal control of sodium excretion in essential hypertession Standard Project continued from 1993 930645 89,551.89 Yes No

Mr P. Hayward Surgery White blood cells and lining of vessels in muscles subjected to blood loss Standard Project starting in 1994 940200 37,464.63 Yes No

Dr J. Hill Dr A. Kaye Surgery Uptake of photosensitizers for laser therapy of

brain tum ours Standard Project continued from 1993 930776 69,972.12 Yes No

Dr G. Hirst Zoology

Control of intestinal movements, with particular em phasis on nervous control system Standard Project continued from 1993 930053 46,514.02 Yes No

130

REGKE Y $

Future supoport 1995 1996

University of Melbourne cont. Dr G. Hirst Dr F. Edw ards Zoology

N ervous control of the circulation Standard Project continued from 1993

Dr G. Hirst Dr M. Klemm Dr F. Edw ards Zoology Relationship between nerve endings calcium channels and muscle cells of heart and intestine

Standard Project starting in 1994

Dr I. Holmes Microbiology How rotaviruses get into cells Standard Project continued from 1992

930154 184,869.17 Yes Yes

940745 65,897.30 Yes Yes

920272 64,891.46 No No

Dr J. H opper Dr J. Carlin Dr L. Flander Dr G. Giles Medicine

The statistical analysis of tw in and family studies Standard Project continued from 1991 911073 115,112.62 Yes No

Dr J. H opper Dr M. McCredie Dr G. Giles Medicine

Does oral contraceptive use increase some wom en's risk for breast cancer? Standard Project continued from 1993 930082 85,712.65 Yes No

Dr D. Horne Dr M. Green Psychiatry Arousal, conditioning and ANV Standard Project starting in 1994 940667 21,346.46 Yes No

REGKEY $

Future supoport 1995 1996

University of Melbourne cont. A /Prof. B. Jackson Medicine Studies of angiotensin converting enzyme in health and disease Standard Project continued from 1993

Dr D. Jackson Dr L. Brown Microbiology Construction of designer immunogens for use as vaccines Standard Project starting in 1994

Prof. C. Johnston Dr P. Phillips Dr L. Burrell

Ms A. Hutchins Medicine Biology of vasopressin Standard Project starting in 1994

A /Prof. F. Judd Dr T. Norman Prof. G. Burrows Psychiatry Biological factors related to neurosis Standard Project starting in 1994

Dr M. Kalloniatis O ptom etry Neurochemical characteristics in an animal model of retinitis pigmentosa Standard Project starting in 1994

Dr B. Key Anatomy Identification of cues used to guide growing nerves in the brain Standard Project continued from 1992

930647 33,498.70 Yes No

940158 137,223.13 Yes Yes

940075 148,561.56 Yes Yes

940135 39,259.16 Yes Yes

940087 41,811.93 Yes Yes

920487 43,273.41 No No

132

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Future supoport 1995 1996

University of Melbourne cont. Dr B. Key Dr V. N urcom be Anatomy G row th factors in the olfactory system

Standard Project starting in 1994 940215 49,031.28 Yes Yes

Dr W. Kim pton Prof. R. Cahill Veterinary Science Role of the thym us in tissue-specific hom ing to

lym ph nodes, spleen and gut Standard Project starting in 1994

Prof. R. Knox Dr M. Singh Dr J. Rolland

School of Botany Epidemiology of grass pollen allergens Standard Project starting in 1994

Dr M. Lightowlers Veterinary Science Diagnosis and prevention of infection with hydatids and related parasites

Standard Project continued from 1993

Dr B. Livett Biochemistry Probes for the m odulatory site of the nicotinic receptor

Standard Project starting in 1994 940153 93,805.03 Yes Yes

Prof. W. Louis Dr A. Gundlach Clinical Pharmacology Characterization of a new class of brain receptors

involved in control of blood pressure Standard Project continued from 1992 920356 43,087.74 No No

940217 72,840.79 No No

940091 129,279.51 Yes Yes

930150 115,108.49 Yes Yes

133

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Future supoport 1995 1996

University of Melbourne cont. Prof. W. Louis Dr G. Jackman Pharmacology C om puter assisted m apping of the beta-adrenoceptor Standard Project continued from 1993

Prof. J. Ludbrook Surgery The role of the central nervous system in circulatory shock Standard Project continued from 1993

Dr P. Marley Biochemistry Interaction of intracellular signals in cells of the adrenal m edulla Standard Project continued from 1993

Dr P. Marley Pharmacology Nitric oxide as a novel messenger from nerves to target cells in the adrenal gland Standard Project starting in 1994

Prof. C. Masters

Mr M. McConville Biochemistry Parasite glycoconjugates Standard Project starting in 1994

Dr D. McQuillan Dr J. Bateman Paediatrics Control of bone formation Standard Project continued from 1993

930732 86,919.11 Yes No

930785 169,866.02 Yes Yes

930136 147,714.49 Yes Yes

940086 44,279.58 Yes No

900431 216,838.07 No No

940732 71,049.39 Yes Yes

930055 85,260.92 Yes No

Pathology A study of the basic causes of Alzheim er's disease Standard Project continued from 1990

134

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Future supoport 1995 1996

University of Melbourne cont. Prof. F. M endelsohn M edicine Angiotensin binding sites in the brain Standard Project continued from 1992 920238 72,214.93 No No

Prof. H. M esser D entistry Fluoride m etabolism Standard Project continued from 1992 920719 42,549.72 No No

Dr P. M olenaar Pharmacology Alterations in heart receptors in disease states and following drug treatm ent Standard Project starting in 1994 940159 102,661.92 Yes Yes

Dr D. Morgan Prof. R. Smallwood Dr M. Ching Medicine Drug elim ination by the foetal liver

Standard Project starting in 1994 940216 49,212.85 Yes Yes

Dr P. Mottram Surgery Treatment of graft rejection and disease recurrence in diabetic mice

Standard Project continued from 1992 920396 53,230.01 No No

Prof. G. Nicholson M edicine Effects of oestrogen on the form ation and activity

of bone resorbing cells (osteoclasts) Standard Project starting in 1994 940066 82,068.13 Yes Yes

Dr V. N urcom be Dr M .Ford Anatom y The means by which embryonic nerve cells capture and use grow th factors Standard Project starting in 1994 940691 93,933.93 Yes Yes

135

REGKEY $

Future supoport 1995 1996

University of Melbourne cont. Prof. A. Pittard Microbiology How do plasm ids m aintain themselves within bacterial cells Standard Project continued from 1992 920297 97,550.22 No No

Dr S. Rees Dr R. Harding Anatomy What does oxygen lack do to the brain before birth? Standard Project starting in 1994 940073 40,295.43 Yes Yes

Prof. M. Renfree Prof. R. Short Dr G. Shaw Zoology _

Effects of hormones on sex differentiation Standard Project starting in 1994 940654 44,157.85 Yes Yes

Prof. M. Renfree Dr J. H arry Zoology How is maleness and femaleness determined Standard Project starting in 1994 940658 55,884.39 Yes Yes

A /Prof. E. Reynolds Dr J. Perich Dental Medicine Potential of casein phosphopeptides to prevent tooth decay Standard Project continued from 1992 920816 74,879.66 No No

A /Prof. E. Reynolds Dr P. Sobieszczuk Dr L. Kirszbaum Mr T. Higgins Dentistry Characterization of proteolytic enzymes from a

pathogenic bacterium Standard Project continued from 1993 930687 60,409.71 Yes No

130

REGKE Y $

Future supoport 1995 1996

University of Melbourne cont. A /Prof. E. Reynolds Dr L. Kirszbaum Dr S. D ashper D entistry

The uptake of sugar by an oral bacterium associated with dental caries Standard Project starting in 1994 940069 53,609.64 Yes Yes

Dr R. Robins-Browne Microbiology M echanisms by which yersinia enterocolitica causes disease Standard Project starting in 1994 940655 81,714.28 Yes Yes

D rC .R u d d u ck Dr O. Garson Medicine The characterization of genetic changes involved

in hum an cancer Standard Project continued from 1992

Dr J. Savige Medicine Inherited diseases of the kidney filter

Standard Project continued from 1992

Prof. W. Sawyer Dr O. Rajaram Biochemistry M echanisms of lipid transport in the blood

Standard Project starting in 1994

Prof. G. Schreiber Biochemistry Passage of thyroid horm ones into the brain Standard Project continued from 19^2

A /Prof. E. Seeman Medicine What are the effects of cortisone on bone thinning and muscle strength? Standard Project continued from 1992 920260 28,596.33 No No

920806 88,918.24 No No

920289 54,045.34 No No

940221 54,098.61 Yes Yes

920262 51,977.67 No No

137

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Future supoport 1995 1996

University of Melbourne cont. A /Prof. E. Seeman Medicine D eterm inants of bone fragility Standard Project continued from 1993 930083 45,756.08 Yes No

Dr A. Shulkes Surgery H orm onal control of the stomach Standard Project continued from 1992 920853 161,621.33 Yes Yes

Dr S. Skinner A /Prof. D. Alcorn Dr D. Campbell Physiology Tissue hormones that regulate blood flow and blood pressure _

Standard Project continued from 1992 920789 76,780.84 No No

Dr D. Small Dr V. Nurcombe Prof. C. Masters Pathology The role of extracellular matrix in A lzheim er's disease Standard Project continued from 1993 930790

Dr D. Small Pathology Acetylcholinesterase and alzheim er's disease Standard Project starting in 1994 940637

Dr R. Summers Dr P. Molenaar Pharmacology Properties and drug sensitivities of novel adrenaline receptors concerned with metabolism Standard Project continued from 1993 930074

Dr R. Summers Pharmacology How drugs alter the rate and force of the heartbeat Standard Project starting in 1994 940657

98,400.75 Yes Yes

36,457.20 Yes Yes

42,118.99 Yes No

49,292.30 Yes Yes

138

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__________________________________________________________ $_____________1995 1996

University of Melbourne cont. Dr T. Suvinen Prof. P. Reade Dr J. G erschm an

D entistry Psychophysiological interactions in facial pain and jaw m alfunction Standard Project continued from 1993 930088 59,134.73 Yes No

Dr L. Sych Prof. P. Reade Dental M edicine Temporal modifications to the arrangem ent and

modification of cells during tooth growth Standard Project continued from 1992 920992 76,265.90 No No

Dr S. Tan Anatomy Animals with new genes to study chromosome function 930086 91,917.47 Yes No

930148 76,831.53 Yes Yes

920468 55,493.81 No No

900343 99,888.01 No No

Standard Project continued from 1993

Dr A. Verberne Prof. W. Louis Clinical Pharmacology Cerebral cortex and the cardiovascular system

Standard Project continued from 1993

, Dr 1. Walker

A /Prof. J. McCluskey Dr P. H udson Veterinary Science Studies on the ability of t cells to recognise

transplantation antigens i Standard Project continued from 1992

Prof. R. Wettenhall Biochemistry Regulation by insulin of gene expression and general protein synthesis in m am m alian liver

Standard Project continued from 1990

139

REGKEY

$

Future supoport 1995 1996

University of Melbourne cont. Dr D. Williams Dr G. Lynch Dr M. Hargreaves Physiology Exercise and peripheral muscle fatigue Standard Project continued from 1993 930684 44,969.28 Yes No

Dr D. Williams Dr G. Lynch Prof. B. Frueh Physiology Physiological properties of extraocular muscles Standard Project starting in 1994 940227 41,811.93 Yes Yes

Dr P. Wilson Prof. D. Bogcr _

Prof. H. Messer Dentistry The effects of crown cementation

Standard Project starting in 1994 940231 36,756.93 Yes Yes

Dr O. Woodman Dr G. Dusting Pharmacology Nitric oxide and nerves controlling blood vessels Standard Project continued from 1992 920455 49,909.99 No No

Dr O. Woodman Pharmacology The effect of ischaemia on the function of blood vessels of the heart Standard Project starting in 1994 940243 33,680.00 Yes Yes

Prof. N. Yeomans Ms M. Skcljo Dr A. Giraud Medicine How does the stomach lining avoid and repair damage?

Standard Project continued from 1993 930683 78,173.37 Yes No

140

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Future supoport 1995 1996

University of Melbourne cont. A /Prof. G. Young Dr R. James Medicine

Regulation of cellular diversity in the gut Standard Project continued from 1992 921122 54,459.97 No No

A /Prof. G. Young Dr P. Gibson Dr R. James Medicine

M echanisms of dietary prevention of bowel cancer Standard Project continued from 1993 930679 51,489.40 Yes No

QUEENSLAND

REGKEY Future supoport

$ 1995 1996

G r iffith U n iv e rs ity Dr F. Clarke Science and Technology The early detection of pregnancy Standard Project continued from 1992 920995 43,273.41 No No

Prof. R. Holmes A /Prof. I. Beacham Prof. L. Hirst Science Inherited susceptibility to uvr induced corneal diseases Standard Project starting in 1994 941098 52,751.35 Yes Yes

Dr J. Leah Dr A. Cameron Science Long-term changes in the brain following painful stimuli Standard Project continued from 1993 930883 70,501.12 Yes No

Dr A. Mackay-Sim Dr G. Bushcll Science and Technology

A study of the mechanism of odour detection Standard Project continued from 1992 921015 45,341.08 No No

James C ook U n iv e rs ity o f N o rth Queensland Dr R. Vink Dr J. Headrick Prof. M. Bendall

Chemistry Alcohol and neurotransmitters following brain injury Standard Project continued from 1993 930858 38,258.12 Yes No

142

REGKEY

$

Future supoport 1995 1996

Queensland In s titu te o f M e d ica l Research

Dr T. Antalis Molecular Biology Laboratory How a gene im portant in inflammation and cancer is suppressed

Standard Project starting in 1994 941079 40,659.39 Yes Yes

Dr P. Brindley Tropical Health Drug resistance in the hum an blood fluke Standard Project starting in 1994 941020 42,210.06 Yes Yes

Dr P. Chen Dr K. Khanna Prof. M. Lavin Cancer Research

Isolation and characterization of genes responsible for ataxia-telangiectasia Standard Project starting in 1994 941051 50,829.39 Yes Yes

Prof. K. Ellem Dr S. Brown Oncology UV causes changes in cell surface enzym es which influence cell behaviour Standard Project continued from 1993 930853 79,931.66 Yes No

Prof. K. Ellem Cancer Medicine Unusual m ethod of localizing proteins which

control formation of mitotic spindle Standard Project starting in 1994 941093 52,245.85 Yes Yes

Dr N. Hayw ard H um an Genetics Unit Isolation of a gene causing tum ours of hormone producing organs

Standard Project continued from 1993 930838 79,931.66 Yes No

Dr N. H ayward H um an Genetics Unit M apping and isolation of melanoma genes Standard Project starting in 1994 941136 106,169.05 Yes Yes

143

RECKEY $

Future supoport 1995 1996

Queensland In s titu te o f M edical Research cont.

Prof. G. Johnson Dr C. Li Pathology Development and dynamics of blood cell production Standard Project starting in 1994 941036 44,339.43 Yes Yes

A /Prof. B. Kay Mosquito Control More ross river transmission with global warming?

Standard Project starting in 1994 941078 40,538.47 Yes Yes

Dr A. Kelso transplantation biology T cell production of the hormones that control im m unity Standard Project continued from 1993 930842 73,056.39 Yes No

Dr A. Kelso Transplantation Unit Specialization among the hormone-producing T cells that control immunity

Standard Project continued from 1993 930863 27,064.18 Yes No

Dr A. Kelso Biology Control of blood cell growth factor production in T cells

Standard Project starting in 1994 941065 52,851.39 Yes Yes

Prof. M. Lavin Dr K. Khanna Cancer Research Unit Hum an genetic disorder and cancer Standard Project continued from 1993 930205 90,380.99 Yes No

Prof. M. Lavin Cancer Medicine Radiation-induced delay of cell cycles passage in human cells Standard Project starting in 1994 941074 44,157.85 Yes Yes

144

REGKEY

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Future supoport 1995 1996

Q ueensland In s titu te o f M e d ica l Research cont.

Prof. M. Lavin Dr D. Findik Dr D. Watters Cancer Research Unit Study of genes involved in cell death Standard Project starting in 1994 941168 52,325.30 Yes Yes

Dr G. Lawrence Dr D. Tudehope A /Prof. V. Yu Dr H. Jeffery Experimental Medicine

Prevention of necrotising enteritis in premature infants with hum an serum antibodies Standard Project continued from 1993 930847 47,819.57 No No

Dr N. Martin Dr A. Green Dr R. MacLennan Dr J. Aitken Epidemiology

Twin and family studies of hereditary and environmental factors in Melanoma Standard Project continued from 1993 930223 95,202.97 Yes No

Dr N. Martin Ms S. Treloar Dr M. Dunne Epidemiology Alcohol use, abuse and dependence: genetic, social and partnership influences

Standard Project starting in 1994 941177 95,781.99 Yes Yes

Dr D. McManus Tropical Health How do cestode parasites protect themselves from rejection by the host?

Standard Project continued from 1992 920441 53,011.50 No No

I

145

REGKEY

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Future supoport 1995 1996

Queensland In s titu te o f M edical Research cont.

Dr D. McManus Molecular Helminthology Antigen differences in different forms of the hydatid tapeworm Standard Project continued from 1993 930848 40,097.80 Yes No

Dr P. Parsons Dr I. Smith Dr A. Green

Dr W. Kelly Cancer Research Natural tum ours in animals as a model for hum an skin cancer Standard Project continued from 1993 930846 72,070.69 Yes No

Dr P. Parsons Dr R. Sturm Dr A. Green Dr G. Strutton Centre Molecular Biology & Medicine Understanding how melanoma and other skin cancers develop on different sites of the body Standard Project starting in 1994

Dr P. Upcroft Dr J. Upcroft Dr P. Boreham Molecular Genetics Laboratory The mechanisms of drug resistance in giardia Standard Project continued from 1992

Dr J. Upcroft Dr P. Upcroft Parasitology Heterogeneity in giardia genome Standard Project starting in 1994

Dr D. Watters Prof. M. Lavin Cancer Research Unit

New marine compounds to study cell growth regulation Standard Project starting in 1994

941077 89,932.24 Yes Yes

921067 109,629.85 No No

941202 62,613.18 Yes Yes

941019 102,010.59 Yes Yes

146

REGKEY Future supoport

__________________________________________________________ $_____________1995 1996

Queensland U n iv e rs ity o f Technology Dr J. Aaskov Life Sciences Immunological properties of composite proteins

from m osquito-borne viruses Standard Project starting in 1994 941146 48,511.17 Yes Yes

Prof. L. Carney Mr M. Collins A /Prof. D. Atchison O ptom etry Vision losses from corneal abnormalities

Standard Project starting in 1994 941110 38,061.52 Yes No

Dr P. Timms Dr L. Hafner Dr R. Epping Dr M. O'Brien Centre Molecular Biology & Medicine Use of harmless bacteria to vaccinate against

mucosal diseases Standard Project starting in 1994 941114 41,175.00 Yes Yes

R oyal Brisbane H o sp ita l

Prof. R. Mortimer Dr G. Cannell Medicine Do changes in placental blood flow or structure

change transfer of drugs from mother to fetus Standard Project starting in 1994 941027 46,789.77 Yes Yes

R oyal B risbane H o sp ita l Research Foundation

Dr P. Dodd Prof. C. Harper Clinical Research Unit H ow the brain is dam aged by alcohol abuse

Standard Project continued from 1993 930989 96,462.82 Yes Yes

147

REGKEY $

Future supoport 1995 1996

Red Cross Blood Transfusion Service, Brisbane Miss C. Hyland Dr Y- Liew Mosquito Control DNA typing for the rh factor: new tools for blood grouping Standard Project starting in 1994 941119 14,154.00 Yes Yes

R oyal C hildren's H o sp ita l, Brisbane Dr J. Pope Dr P. Young Sir Albert Sakzewski VRL Pathogenesis of viral infections: respiratory syncytial virus Standard Project continued from 1990 901075 161,523.59 No No

Prof. E. Westaway ·

Sir Albert Sakzewski VRL Infectious genetic material from Australian virus associated with encephalitis Standard Project continued from 1992 920114 60,226.30 No No

Dr P. Young Sir Albert Sakzewski VRL Antiviral agents for the control of respiratory infections Standard Project starting in 1994 941199 43,869.21 Yes Yes

U n iv e rs ity of Queensland Dr M. Aldred Dentistry X-linked amelogenesis imperfecta Standard Project starting in 1994 941054 42,375.06 Yes Yes

Prof. P. Andrews Dr D. Fairlie Dr P. Alewood Dr R. Brinkworth Drug Design and Development

New drugs for the treatment of AIDS Standard Project continued from 1993 931170 66,978.59 Yes No

148

REGKEY $

Future supoport 1995 1996

U n iv e rs ity o f Q ueensland cont.

Prof. P. Bartold Pathology Treatment for periodontal disease Standard Project continued from 1992 920711 41,205.73 No No

Dr M. Calford Physiology and Pharmacology Short-term changes in the brain following nerve injury

Standard Project continued from 1992 921045 125,444.40 Yes Yes

Dr J. Campbell Anatomy Cell biology of vascular disease Standard Project continued from 1992 921043 103,202.14 Yes Yes

Dr J. Campbell Prof. G. Campbell Anatomy Mechanisms of vascular occlusion following

arterial injury Standard Project continued from 1993 931143 58,851.53 Yes No

Dr A. Cavanagh Dr K. Summers Dr H. Morton Surgery Investigation of early pregnancy factor appearance control and function within the cell Standard Project starting in 1994 941038 54,375.35 Yes Yes

Dr A. Cody Physiology Changes in patterns of activity in the brain after damage to the cochlea

Standard Project continued from 1993 930229 29,896.57 Yes No

Dr M. Dadds Dr S. Spence Psychology Detection and prevention of child anxiety problems

Standard Project starting in 1994 941013 69,936.13 Yes Yes

149

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Future supoport 1995 1996

U n iv e rs ity of Queensland cont.

Dr T. Day Physiology and Pharmacology Brainstem mechanisms controlling hormone secretion Standard Project starting in 1994

Dr J. De Jersey Dr S. Worrall Dr P. Wilce Biochemistry Damage to tissue proteins as a marker of alcohol abuse Standard Project continued from 1992

Dr R. Dickinson Medicine The effects of unstable degradation products of certain drugs in the body Standard Project starting in 1994

Dr A. Dugdale Dr I. Ring Child Health An analysis of aboriginal health in Queensland and over 40 years Standard Project continued from 1992

Dr T. Florin Dr D. Cowley Medicine Dietary sulphate, bacteria and bowel disease Standard Project starting in 1994

941135 76,688.05 Yes Yes

920217 41,205.73 No No

941083 168,482.55 Yes Yes

920674 56,564.36 No No

941073 48,888.93 Yes Yes

A /Prof. I. Frazer Dr R. Tindle Immunology A model for understanding human papillomavirus infection, and a vaccine Standard Project continued from 1993 930309 46,766.67 Yes No

150

REGKEY $

Future supoport 1995 1996

U n iv e rs ity o f Q ueensland cont.

Dr M. Frenneaux Medicine Sudden death in heart disease possible role of ventricular baroreceptor activation

Standard Project starting in 1994 941193 45,757.97 Yes Yes

Prof. G. Geffen Clinical Research Unit Assessment of head injury: mental tests, brain electrical responses and images

Standard Project continued from 1992 921104 45,672.33 No No

Dr S. Ghosh Physiology and Pharmacology The role of touch in the control of skilled movements Standard Project continued from 1992 921033 62,647.55 No No

Prof. R. Gordon Mr T. Tunny Dr S. Klemm Medicine

Structure, function and inheritance of tum ours causing high blood pressure Standard Project continued from 1992 920590 50,172.84 No No

Prof. R. Gordon Mr T. Tunny Dr S. Klemm Endocrine Unit

Hormonal excess causing high blood pressure due to inherited defects Standard Project continued from 1993 930979 42,300.51 Yes No

A/Prof. W. Halford Prof. J. Price Psychiatry Helping wives of male problem drinkers

Standard Project continued from 1992 921065 39,672.53 No No

REGKEY Future supoport

$ 1995 1996

U n iv e rs ity of Queensland cont.

A/Prof. W. Halford Psychiatry Helping schizophrenic patients cope Standard Project continued from 1993 930872 50,679.71 Yes No

Dr D. Hume Dr T. Dunn Centre Molecular Biology & Medicine Role of the hormone CSF-1 in toxic shock syndrome and bacterial infection Standard Project continued from 1992 920071 41,205.73 No No

Dr D. Hume Dr 1. Ross Dr T. Dunn Dr A. Cassady Centre Molecular Biology & Medicine Molecular studies of macrophage differentiation Standard Project continued from 1993 930302 103,113.42 Yes No

Dr D. Hume Ms K. Stacey Molecular Biology and Biotechnology The relationship between macrophages and tum our cells Standard Project continued from 1993 931021 43,129.59 Yes No

Dr R. Jackson Dr J. Grice Dr D. Torpy Medicine Effect of drugs on stress hormone levels Standard Project continued from 1993 930305 44,616.94 Yes No

Dr D. James Centre Molecular Biology & Medicine Molecular biological studies of insulin-stimulated glucose transport Standard Project continued from 1993 930299 83,974.05 Yes No

152

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Future supoport 1995 1996

U n iv e rs ity o f Q ueensland cont.

Dr D. James Centre Molecular Biology & Medicine How does insulin stim ulate glucose transport in muscle and fat cells?

Standard Project continued from 1993 930301 49,193.16 Yes No

Dr J. Keast Physiology and Pharmacology Nerves supplying the bladder, colon and reproductive organs

Standard Project starting in 1994 941085 44,117.01 Yes Yes

Dr P. Koopman Centre Molecular Biology & Medicine Mouse models of hum an sex reversal Standard Project continued from 1993 930304 94,949.25 Yes No

A /Prof. P. Kroon A /Prof. R. Smith Biochemistry

The structure of the low-density lipoprotein receptor Standard Project continued from 1993 930597 42,300.51 Yes No

A /Prof. S. Manley Dr J. Bourke Dr G. Huxham Physiology and Pharmacology

Transport of salt and w ater by thyroid gland cells Standard Project continued from 1993 930249 52,224.95 Yes No

Dr L. Martin Physiology and Pharmacology Analysis of how uterus and oviduct muscles are regulated in early pregnancy

Standard Project continued from 1992 921031 57,231.55 No No

Prof. J. Mattick Molecular Biology and Biotechnology Assembly of surface filaments required for tissue attachment by bacteria

Standard Project continued from 1992 920588 100,420.27 No No

153

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$ 1995 1996

U n iv e rs ity of Queensland cont.

Prof. J. Mattick Dr R. Don Biotechnology Genes that control development of the mammalian embryo Standard Project continued from 1993 930252 46,342.89 Yes No

Prof. M. McManus Clinical Pharmacology Characterization of how hum an tissues metabolize carcinogens Standard Project continued from 1992 920610 136,890.35 No No

Prof. M. McManus Prof. L. Sansom Dr M. Veronese Clinical Pharmacology Characterization of human sulfotransferases involved in xenobiotic metabolism Standard Project continued from 1992 920678 49,476.44 No No

Dr B. Mo wry Dr N. Hayward Clinical Studies Unit A study of abnormalities in the genetic code that produce vulnerability to schizophrenia Standard Project starting in 1994 941087 140,081.80 Yes Yes

A/Prof. B. Murdoch Ms H. Chenery Speech and Hearing Instrumental assessment of disordered speech in head injury and stoke Standard Project continued from 1993 930957 34,390.92 Yes No

Dr G. Muscat Centre Molecular Biology & Medicine Hormonal control of muscle development Standard Project starting in 1994 941097 101,895.00 Yes Yes

154

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Future supoport 1995 19%

iI I

U n iv e rs ity of Q ueensland cont.

Dr P. Nixon Dr S. Rose Dr F. Zelaya Biochemistry

New approaches to understanding the brain damage characteristic of vitamin B1 deficiency Standard Project starting in 1994 941032 55,884.39 Yes Yes

A/Prof. M. Pender Dr P. McCombe Medicine Cell death in the nervous system in demyelinating disease Standard Project continued from 1992 920284 79,798.95 No No

A/Prof. M. Pender Dr P. McCombe A/Prof. M. Good Medicine

Studies of lymphocyte function in m ultiple sclerosis Standard Project continued from 1993 930316 54,246.14 Yes No

Prof. J. Pettigrew Physiology and Pharmacology Binocular vision during development of flying foxes and owls

Standard Project continued from 1991 910423 108,740.58 Yes No

Dr B. Polak Mr P. Bird Prof. G. Seymour Dentistry The study of im portant proteins of p. gingivalis

Standard Project continued from 1992 920756 53,629.89 No No

Prof. S. Pond Dr L. Rivory Medicine Drug treatment of liver cancer Standard Project continued from 1992 920298 64,065.52 No No

il

155

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Future supoport 1995 1996

U n iv e rs ity o f Queensland cont.

Prof. S. Pond Medicine How the liver cells from males and females extract substances from the bloodstream Standard Project continued from 1993 930966 69,413.05 Yes No

Prof. B. Raphael Dr B. O'Toole Dr P. Burnett Psychiatry Preventing psychiatric problems after very stressful experiences Standard Project continued from 1992

Dr P. Reilly Dr E. Gillam Dr W. Hooper Biochemistry Expression and regulation of some drug metabolizing enzymes in hum an liver Standard Project continued from 1993

Prof. M. Roberts Medicine Solute structure and physiological modelling of hepatic elimination Standard Project continued from 1993

Prof. M. Roberts Medicine Drug delivery through the skin Standard Project starting in 1994

A /Prof. M. Sanders A /Prof. R. Shepherd Dr G. Cleghorn Psychiatry Children with persistent feeding problems Standard Project continued from 1992

921066 73,712.99 No No

930590 50,809.06 Yes No

930388 95,906.21 Yes No

941155 63,094.99 Yes Yes

920700 56,360.88 No No

156

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$ 1995 1996

U n iv e rs ity o f Q ueensland cont.

A /Prof. M. Sanders DrW . Bor Psychiatry The prevention of antisocial behaviour problems

in children Standard Project starting in 1994 941044 101,497.52 Yes Yes

Dr N. Savage Dr L. Walsh Dentistry Development of early skin and oral mucosal disease processes Standard Project continued from 1992 920777 48,876.15 No No

A /Prof. C. Semia Physiology and Pharmacology Hormones regulating blood pressure Standard Project continued from 1992 921106 84,912.69 No No

A /Prof. C. Semia Physiology and Pharmacology A brain system that controls blood pressure Standard Project continued from 1993 930886 46,063.96 Yes No

Prof. G. Seymour Prof. R. Reinhardt Prof. P. Bartold Dentistry

Immune responses as predictors of gum disease Standard Project continued from 1993 930477 50,664.54 Yes No

Prof. P. Smith Pathology Genetic changes that lead to cancer Standard Project continued from 1992 921010 47,223.09 No No

Prof. P. Smith Dr E. Algar Pathology Studies of a gene that m ay be im portant in cancer

Standard Project continued from 1993 930882 51,819.65 Yes No

157

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__________________________________________________________ $_____________1995 1996

U n iv e rs ity o f Queensland cont.

Prof. P. Smith Ms J. Glatz Pathology Epigenetic factors in causation of human cancer Standard Project starting in 1994 941015 58,502.51 Yes Yes

A /Prof. R. Smith Biochemistry The assembly of myelin in the central nervous system Standard Project starting in 1994 941128 49,212.85 Yes Yes

A /Prof. P. Snow Dr P. Wilson Anatomy Regulation of the effects of nerve injury or limb am putation on brain pathways Standard Project continued from 1990 901045 175,887.09 No No

Dr R. Sturm Dr P. Parsons Molecular Biology and Biotechnology Control proteins in melanoma and related cells Standard Project starting in 1994 941026 84,877.24 Yes Yes

Dr R. Tindle Dr G. Fernando Medicine A vaccine for cervical cancer Standard Project continued from 1992 920330 61,221.05 No No

A /Prof. A. Tsoi Dr A. Serge jew Electrical Engineering Artificial neural net classification of EEG signals in

psychiatric disorders Standard Project continued from 1992 920224 42,479.81 No No

Dr D. Vaney Physiology and Pharmacology How the eye detects movement Standard Project continued from 1991 910414 163,248.85 Yes No

158

REGKEY Future supoport

$ Ί995 1996

U n iv e rs ity o f Q ueensland cont.

Dr B. Wainwright Molecular Biology and Biotechnology The determ ination of the cause of skin cancer Standard Project continued from 1992 920580 99,200.76 No No

Dr B. Wainwright Dr S. Delaney Molecular Biology and Biotechnology The molecular genetics of cystic fibrosis

Standard Project continued from 1993 930973 98,465.75 Yes No

Dr J. Wanstall Prof. S. O'Donnell Physiology and Pharmacology Drugs for treating pulm onary hypertension

Standard Project continued from 1991 910370 100,102.67 Yes No

Dr B. Ward Dr M. McGuckin Obstetrics/Gynaecology Examination of a substance secreted into blood

by breast and ovarian cancer Standard Project continued from 1992 921140 51,977.67 No No

Dr M. Waters Dr G. Muscat Physiology and Pharmacology An analysis of growth hormone receptor action by protein engineering

Standard Project continued from 1992 921059 85,655.39 No No

Dr M. Waters Physiology and Pharmacology Mechanisms of growth hormone action Standard Project continued from 1993 930251 86,906.77 Yes No

Prof. M. West Dr K. Summers Dr D. Burstow Medicine Genetic factors in cardiac hypertrophy and

hypertension Standard Project continued from 1993 930972 68,235.05 Yes No

159

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Future supoport 1995 1996

U n iv e rs ity of Queensland cont.

Dr P. Wilce Dr I. Matsumoto Prof. B. Shanley Biochemistry Molecular basis of ethanol-induced brain damage Standard Project starting in 1994 941075 96,137.51 Yes Yes

Dr R. Wong Dr D. Vaney vision, touch and hearing Imaging structure and function in the developing retina Standard Project continued from 1993 930295 3,704.84 Yes No

Dr J. Zhou A /Prof. I. Frazer Medicine H ow w art viruses work Standard Project continued from 1993 930982 56,098.17 Yes No

160

SOUTH AUSTRALIA

REGKEY Future supoport

__________________________________________________________ $_____________1995 1996

A delaide M e d ica l C entre fo r Women and C h ild re n Dr G. Davidson Prof. J. Dent Dr R. Haslam

Neonatal Intensive Care Unit Development of lower oesophageal sphincter and oesophageal body function in preterm infant Standard Project starting in 1994 940312 40,448.80 Yes Yes

Prof. A. Ferrante Dr A. Martin Dr L. Beard Immunology Stimulation of bacterial killing by hormone-like imm une molecules Standard Project continued from 1992 920079 43,151.32 No No

Prof. A. Ferrante Dr A. Poulos Immunology Effect of unsaturated fats on production of

substances which cause damage to body tissue Standard Project continued from 1992 920586 44,226.10 No No

Prof. A. Ferrante Dr B. Robinson Dr D. Ellis A/Prof. C. Easton

immunology Increasing body defences with fats Standard Project continued from 1993 930743 47,591.22 Yes Yes

Prof. A. Ferrante Dr I. Kowanko Dr D. Rathjen Dr R. Byard

Immunology Molecules which cause or prevent cartilage damage in the body Standard Project starting in 1994 940364 45,297.23 Yes Yes

161

REGKEY

$

Future supoport 1995 1996

A delaide M e d ica l Centre fo r Women and C h ild re n cont.

Dr C. Morris Dr W. Carey Chemical Pathology The molecular understanding of metachromatic

leukodystrophy Standard Project starting in 1994 940363 36,404.80 Yes Yes

Dr J. Pa ton Dr D. Hansman Microbiology Understanding pneumococcal disease Standard Project continued from 1993 930607 87,478.53 Yes No

Dr A. Poulos Dr H. Singh Dr B. Paton *

Chemical Pathology Peroxisomal disorders Standard Project starting in 1994 940365 127,310.20 Yes Yes

F linders U n iv e rs ity of South A ustralia Dr G. Barritt Medical Biochemistry Signals within cells which perm it hormones to control liver function Standard Project continued from 1993 931118 89,714.76 Yes No

A /Prof. D. Ben-Tovim Ms M. Walker Prof. R. Kalucy Dr P. Gilchrist Psychiatry Long-term outcome prediction in eating disorders Standard Project starting in 1994 940100 44,739.38 Yes Yes

Prof. M. Berry Dr D. Henly Dr J. Phillips Medical Biochemistry Energy-dependent regulation of metabolism in health and disease Standard Project continued from 1993 931161 166,947.80 Yes No

162

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Future supoport 1995 1996

Flinders U n iv e rs ity o f S outh A u stra lia cont.

Prof. D. Birkett Prof. J. Miners Prof. M. McManus Clinical Pharmacology Towards safe and effective drug therapy:

predicting how people break down drugs Standard Project continued from 1990

Dr W. Blessing Medicine Homeostasis and the lower brainstem Standard Project starting in 1994

Prof. M. Costa Physiology Functions of nerves controlling gut movements Standard Project continued from 1992

Prof. M. Costa Dr S. Brookes Physiology Nerve cells that control gut movement Standard Project continued from 1992

Prof. M. Costa Dr S. Brookes Human Physiology Nerve cell that controls the movement of the stomach Standard Project starting in 1994

A/Prof. A. Crocker Dr S. Johnson Clinical Pharmacology Control of behaviour by brain cells

Standard Project continued from 1992

900960 131,588.27 No No

940102 195,039.43 Yes Yes

920229 47,037.43 No No

920733 59,264.69 No No

940256 48,605.19 Yes Yes

920732 82,040.11 No No

REGKEY Future supoport

__________________________________________________________ $_____________1995 1996

F linders U n iv e rs ity o f South A ustralia cont.

A /Prof. J. Finlay-Jones Dr P. Kenny Dr P. Hart Prof. P. McDonald Microbiology and Immunology Cells of the imm une system can both promote and inhibit infection Standard Project continued from 1992

Prof. K. Forsyth Child Health Immunology of hum an endothelium Standard Project continued from 1992

Prof. 1. Gibbins Anatomy and Histology How do nerves control blood flow? Standard Project starting in 1994

Dr T. Gordon Clinical Immunology Specific im m une responses in autoimmune diseases Standard Project continued from 1993 931166 40,097.80 Yes No

Dr P. Hart A /Prof. J. Finlay-Jones Prof. P. McDonald Microbiology Studies of a mediator that may control human inflammation Standard Project starting in 1994 940189 128,842.86 Yes Yes

Dr B. Kalionis Dr W. Jones Obstetrics/Gynaecology The isolation of genes that control mammalian development Standard Project starting in 1994 940191 85,845.93 Yes Yes

920726 59,456.09 No No

920349 41,536.98 No No

940254 96,698.17 Yes Yes

104

REGKEY

$

Future supoport 1995 1996

F linders U n iv e rs ity o f S outh A u stra lia cont.

Dr K. Knights Clinical Pharmacology The role of the liver in breaking dow n drugs and chemicals in hum ans

Standard Project continued from 1993 930479 43,129.59 Yes No

Dr P. Mackenzie Clinical Pharmacology Processes in the cell that inactivate drugs and toxins Standard Project continued from 1991 910303 166,993.62 Yes No

A /Prof. J. McCluskey Dr T. Gordon Dr A. Guidolin Dr L. McNeilage

Clinical Immunology Immune self-tolerance and autoim m une disease Standard Project continued from 1992 920231 91,657.71 No No

A/Prof. J. McCluskey Dr B. Toh Clinical Immunology Characterisation of molecules which control protein

trafficking inside cells Standard Project starting in 1994 940105 58,311.85 Yes Yes

Prof. A. Morley Dr D. Turner Dr F. Firgaira Haematology

Mutations in hum an cells Standard Project continued from 1992 920656 91,819.41 No No

Prof. A. Morley Dr M. Brisco Dr P. Sykes Haematology Improving treatm ent for childhood leukaemia

Standard Project starting in 1994 940800 75,535.85 Yes Yes

165

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$

Future supoport 1995 1996

F linders U n iv e rs ity o f South A u stra lia cont.

Dr J. Morris Prof. I. Gibbins Anatomy and Histology Nerves can regulate blood flow by releasing neuropeptides Standard Project continued from 1992

Prof. A. M urray Biological Science Role of lipids in the regulation of cell behaviour Standard Project starting in 1994

Dr T. Neild Dr N. Kotecha Physiology Mechanisms by which neuropeptide Y increases blood vessel constriction Standard Project continued from 1993

Prof. T. Nicholas Dr M. Jones Physiology Physiology and pathophysiology of surfactant Standard Project continued from 1992

Prof. T. Nicholas Dr C. McDonald Mr A. Crockett Human Physiology Role of the lining of the lung in breathing in humans Standard Project continued from 1993

Dr J. Power Physiology Proteins and surfactant Standard Project continued from 1992

Dr R. Rodgers A /Prof. S. Judd Medicine How the ovary produces hormones Standard Project continued from 1993

920615 106,927.11 Yes Yes

940276 58,081.35 Yes Yes

931005 86,271.51 Yes No

920134 103,884.39 No No

930484 40,279.31 Yes No

920110 38,104.20 No No

930215 109,557.43 Yes Yes

166

REGKEY

$

Future supoport 1995 1996

F linders U n iv e rs ity o f S outh A u stra lia cont.

Dr R. Rush Physiology Function of growth factors in sensory nerves Standard Project continued from 1992

Dr R. Rush Physiology Self-regulation of nerve survival Standard Project starting in 1994

Dr R. Ryall Dr P. Grover Surgery Proteins in urine m ay play a role in kidney

stone disease Standard Project starting in 1994

Dr G. Saccone Prof. J. Toouli Surgery Nervous communication in the gut Standard Project continued from 1993

A /Prof. C. Straznicky Anatomy and Histology Monoamine-containing neurons of the retina

Standard Project continued from 1993

Dr P. Sykes Prof. A. Morley Haematology Sensitive detection of disease in leukaemia

patients after treatm ent Standard Project continued from 1993

Dr W. Tilley Prof. V. Marshall Surgery The study of factors influencing the growth of

hum an prostate cancer Standard Project continued from 1992

920250 87,642.86 No No

940792 45,420.54 Yes Yes

940283 64,203.43 Yes Yes

930822 9,186.54 Yes Yes

930586 66,522.38 Yes No

931112 39,087.21 No No

920683 116,626.14 Yes Yes

167

REGKEY

$

Future supoport 1995 1996

F linders U n iv e rs ity o f South A u stra lia cont.

Dr M. Veronese Prof. D. Birkett Clinical Pharmacology

Activation of chemicals that cause lung cancer Standard Project starting in 1994 940080 8,088.00 Yes Yes

Dr K. Williams Prof. D. Coster Ophthalmology Graft survival and visual outcome after corneal transplantation Standard Project continued from 1992 920628 15,447.26 No No

Dr K. Williams Prof. D. Coster Ophthalmology Transplantation for the treatm ent of corneal disease Standard Project starting in 1994 940175 79,766.70 Yes Yes

A /Prof. J. Willoughby Medicine The biological clock that produces growth

horm one rhythms Standard Project continued from 1992 920760 31,221.20 No No

A /Prof. J. Willoughby Dr J. Hiscock Medicine Brain disturbances underlying grand mal and petit mal epilepsies Standard Project continued from 1993 930497 60,661.15 Yes No

Prof. H. Zola Mr P. Macardle Clinical Immunology

Blood cells that make antibody: how they are turned on and controlled Standard Project continued from 1993 930594 44,310.70 Yes No

1 6 8

REGKEY

$

Future supoport 1995 1996

In s titu te o f M e d ica l and V eterinary Science Dr L. Ashman Leukemia Research & Viral Pathology A growth factor receptor involved in hum an

leukaemia Standard Project continued from 1992

Dr L. Ashman Hanson Centre for Cancer Research Hum an m ast cell differentiation Standard Project starting in 1994

Dr R. Bais Dr A. Rofe Dr K. Bannister Clinical Chemistry

Approaches to reducing kidney stone formation Standard Project continued from 1992

Dr S. Efstathiou Medical Virology Pathogenic properties of a rodent herpes virus related to Epstein-Barr virus

Standard Project continued from 1992

920252 170,070.73 Yes Yes

940195 43,794.70 Yes Yes

920604 31,889.94 No No

920917 45,341.08 No No

Dr T. Gonda Dr J. Rayner Hanson Centre for Cancer Research Use of novel gene cloning method to study blood

cell development Standard Project continued from 1993 930259 128,494.68 Yes Yes

Dr T. Gonda H um an Immunology U nderstanding how a potential cancer gene — myb — exerts its effects

Standard Project starting in 1994 940149 43,976.28 Yes Yes

Dr E. Gowans Microbiology An im proved vaccine for hepatitis B virus Standard Project continued from 1993 930141 50,809.06 Yes No

169

REGKEY

$

Future supoport 1995 1996

In s titu te o f M edical and V e te rin a iy Science cont.

Dr E. Go wans Microbiology Growth of hepatitis delta virus Standard Project continued from 1993 931124 42,147.43 Yes No

Dr E. Go wans Dr T. Macnaughton Medical Virology The cell protein which binds hepatitis B virus Standard Project starting in 1994 940275 45,774.39 Yes Yes

Dr G. Higgins Prof. C. Burrell Medical Virology Expression of wart virus in cultured cells Standard Project continued from 1992 920644 49,476.44 Yes No

Dr T. Hughes Hanson Centre for Cancer Research Importance of a novel gene 'ab l/b cr' in leukaemia Standard Project starting in 1994 940653 39,284.43 Yes Yes

Dr C. Juttner Dr C. Hutchins Dr L. To Haematology Identify residual normal cells in leukaemia Standard Project continued from 1993 930384 43,129.59 Yes No

Dr A. Simmons Dr S. Efstathiou Medical Virology Analysis of herpes latency Standard Project continued from 1992 920918 73,840.45 No No

Dr P. Simmons Dr C. Juttner Dr B. To Leukemia Research & Viral Pathology Studies of how cell suitable for transplantation are released into the blood Standard Project continued from 1993 930245 51,920.71 Yes No

170

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Future supoport 1995 1996

In s titu te o f M e d ica l and V eterinary Science cont.

Dr P. Simmons Leukemia Research & Viral Pathology To study a vital supporting (stromal) cell population in hum an bone marrow

Standard Project continued from 1993 930253 49,193.16 Yes No

Dr A. Simmons Medical Virology Regulation of im m unity to herpes Standard Project continued from 1993 930929 38,342.70 Yes No

Dr L. To Mr D. Haylock Dr P. Simmons Dr C. Juttner

Hanson Centre for Cancer Research Safer bone marrow transplantation using stimulated blood cells Standard Project continued from 1992

Queen E lizabeth H o sp ita l

Dr G. Russ Dr R. Krishnan Immunology Soluble imm une factors in kidney transplants

Standard Project starting in 1994

Royal A delaide H o sp ita l

Dr L. Blackshaw Prof. J. Dent Gastroenterology Reflexes controlling the valve between s

tomach and oesophagus Standard Project starting in 1994

A /Prof. L. Cleland Dr R. Gibson Dr M. James Rheumatology

Fatty acids and inflammation Standard Project continued from 1993

920350 48,442.60 No No

940318 47,695.59 Yes Yes

940778 74,095.56 Yes Yes

930913 51,821.83 Yes No

171

REGKEY $

Future supoport 1995 1996

Royal A d e la id e H ospital cont.

A /Prof. L. Cleland Dr B. Kirkham Rheumatology T helper cell function in arthritis

Standard Project starting in 1994 940361 41,925.26 Yes Yes

Prof. J. Dent A /Prof. M. Horowitz Medicine Muscular controls of flow of food from the stomach to the small intestine Standard Project continued from 1992 920870 65,846.89 No No

A /Prof. M. Horowitz Prof. J. Dent Dr W. Sun Dr D. Kilpatrick Medicine Effect of diabetes on stomach function — the role of stomach emptying in the control of Standard Project starting in 1994 940270 49,002.26 Yes Yes

Prof. D. Howie A /Prof. M. Pearcy Dr S. Graves Orthopaedics

Bone loss around joint replacements Standard Project starting in 1994 940793 64,444.43 Yes Yes

Dr Gr Mayrhofer A /Prof. L. Cleland Hanson Centre for Cancer Research Mechanisms of accumulation of T lymphocytes in normal and inflamed joints Standard Project starting in 1994 940520 59,449.01 Yes Yes

R epatriation General H ospital, D aw Park Dr R. McEvoy Prof. N. Saunders Sleep disorders Oxygen deprivation and breathing awake and asleep Standard Project starting in 1994 940198 41,666.23 Yes Yes

172

REGKEY

$

Future supoport 1995 1996

R epatriation General H o sp ita l, D a w Park cont.

Dr R. McEvoy Prof. N. Saunders Dr A. Bune Dr D. Sajkov

Sleep disorders Pulmonary hypertension in obstructive sleep apnea Standard Project starting in 1994 940723 47,805.18 Yes Yes

U n iv e rs ity o f A d e la id e Dr R. Barrett Psychiatry A study com paring m ental illness in tw o different

cultures Standard Project continued from 1993 930971 41,331.14 Yes No

Prof. P. Barter Dr K. Rye Medicine Relationship between the composition, structure and function of high density lipoproteins

Standard Project starting in 1994

Prof. C. Burrell Microbiology and Immunology Factors affecting the outcome of hepatitis B-like infections

Standard Project continued from 1992

Dr E. Cleary Dr J. Kumaratilake Pathology The role of ultraviolet light on premature

ageing of skin Standard Project continued from 1993

Dr P. Ey Dr G. Mayrhofer Microbiology and Immunology Surface proteins of the intestinal parasite giardia

Standard Project starting in 1994 940324 139,309.16 Yes Yes

940843 38,091.85 Yes Yes

920122 49,476.44 No No

930967 65,502.02 Yes No

173

REGKEY Future supoport

$ 1995 1996

U n iv e rs ity o f A delaide cont.

Dr M. Gibson Dr E. Cleary Pathology Microfibrils control elastin formation and function in health and diseases Standard Project continued from 1993 931106 112,475.31 Yes Yes

Prof. J. Horowitz Dr Y. Chirkov Cardiology Nitrate tolerance in arteries and platelets Standard Project starting in 1994 940289 40,699.83 Yes Yes

Dr D. Kennaway Dr R. Seamark Obstetrics/Gynaecology Interactions between the pineal gland and the brain biological clock Standard Project continued from 1992 920172 108,024.18 Yes Yes

Prof. P. Manning Dr R. Morona Microbiology and Immunology Role of surface structures in the ability of Shigella flexneri to invade and cause disease Standard Project continued from 1992 920140 48,442.60 No No

Prof. P. Manning Dr S. Williams Microbiology and Immunology Studies on bacterial factors associated with cholera infections Standard Project continued from 1992 920141 102,798.14 Yes Yes

Prof. P. Manning Microbiology and Immunology Factors affecting adherence of bacteria in diarrhoea! disease due to E.coli Standard Project continued from 1992 920652 49,105.10 No No

174

REGKEY

$

Future supoport 1995 1996

U n iv e rs ity of A d e la id e cont.

Prof. P. Manning Dr S. Attridge Microbiology Relevance of bacterial surface structure to

vaccine developm ent Standard Project continued from 1993 931125 63,294.04 Yes No

Dr B. May Biochemistry Control of heme biosynthesis and its relation to diseases

Standard Project continued from 1993

Dr B. May Dr S. Dogra Biochemistry Induction of proteins which protect the body against foreign chemicals Standard Project continued from 1993

Dr G. Mayrhofer Microbiology and Immunology A new concept in mucosal defence Standard Project continued from 1992

Prof. A. McFarlane Psychiatry Early distress response as a predictor of posttraumatic stress disorder in traum a victims Standard Project continued from 1993

930455 83,003.61 Yes No

930564 65,849.79 Yes No

920088 43,273.41 No No

930459 53,628.37 Yes No

Prof. A. McFarlane Dr C. Clark Psychiatry Biological typing in PTSD by analysis of

brainwave patterns Standard Project starting in 1994 940303 60,973.49 Yes Yes

Prof. I. McMillen Physiology Control of the fetal response to stress in the womb Standard Project continued from 1993 930401 48,182.57 Yes No

175

REGKEY $

Future supoport 1995 1996

U n iv e rs ity o f A delaide cont.

Dr R. Morona Microbiology and Immunology Identification of genes which are specifically involved in the virulence of salmonella species which cause enteric fever in man Standard Project starting in 1994

Dr R. Norman Dr M. Brannstrom Obstetrics / Gynaecology Lh and leukocytes in rodent ovary Standard Project starting in 1994

Dr J. Owens Prof. J. Robinson Obstetrics/Gynaecology Treatment of fetal growth failure with growth factors Standard Project continued from 1992

Dr H. Richardson Dr R. Saint Biochemistry The regulation of growth during development Standard Project starting in 1994

Ms S. Robertson Dr R. Seamark Obstetrics/Gynaecology Epithelial cytokines in reproduction

Standard Project starting in 1994

Prof. W. Runciman Dr G. Osborne Anaesthesia and Intensive Care M anipulating heart and brain drug levels to optimise i.v. anaesthesia Standard Project continued from 1993

940319 41,124.85 Yes Yes

940295 42,135.85 Yes Yes

920807 108,653.80 Yes Yes

940304 37,936.32 Yes Yes

940339 82,612.85 Yes Yes

930584 46,198.36 Yes No

176

REGKEY Future supoport

$ 1995 1996

U n iv e rs ity of A d e la id e cont.

Prof. F. Bochner Clinical & Experim ental Pharmacology Why are the elderly prone to exaggerated effects of codeine?

Standard Project continued from 1992 920147 36,036.53 No No

A /Prof. G. Townsend Prof. T. Brown Dr L. Richards Dr G. Travan

Dentistry Genetic studies of the teeth and faces of Australian twins Standard Project continued from 1992 920612 50,990.29 No No

Dr K. Turker Physiology Reflex control of jaw muscles

U n iv e rs ity o f S outh A u s tra lia

Dr A. Evans Prof. R. Nation Pharmacy How the liver and the kidneys handle

morphine, a drug used for the treatm ent of pain

Standard Project starting in 1994 940829 73,527.94 Yes Yes

Standard Project starting in 1994 940330 37,262.43 Yes Yes

177

WESTERN AUSTRALIA REGKEY Future supoport

1995 1996 ________________________ ____________________________ $_

A u stra lia n N eurom uscular Research In stitu te Dr M. Garlepp Prof. F. Mastaglia Medicine An analysis of the properties of lymphocytes which react with muscle Standard Project starting in 1994 940696 44,844.93 Yes Yes

Dr N. Laing Identification of a gene for the inherited disorder nemaline myopathy Standard Project starting in 1994 940122 43,328.43 Yes Yes

Dr C. Lawson Dr M. Garlepp Research '

The investigation of a possible taiget molecule for muscle reactive lymphocytes in myositi Standard Project starting in 1994 940155 81,173.28 Yes Yes

Dr R. Stell Prof. F. Mastaglia Australian Neuromuscular Research Institute Fast eye movement abnormalities in patients with focal brain lesions Standard Project continued from 1992 920906 23,583.09 No No

C u rtin U n iv e rs ity o f Technology Dr K. Singer Dr P. Breidahl Mr R. Day Biomedical Engineering Spinal structure and function: relationships in osteoporosis Standard Project continued from 1993 930465 18,484.20 Yes No

Dr J. Warmington Biological Science A study into how the pathogenic yeast Candida albicans causes infection Standard Project continued from 1992 920898 47,223.09 No No

178

REGKEY Future supoport

$ 1995 1996

M urdoch University Dr P. Drum m ond Psychology Sensitivity to noradrenaline in chronic pain

Standard Project starting in 1994 941226 33,392.32 Yes Yes

Dr J. Reynoldson A /Prof. R. Thompson Dr A. M endis Veterinary Science

New approaches to treating giardiasis and other protozoan infections Standard Project continued from 1993 930500 38,288.44 Yes No

A /Prof. J. Webb Dr D. Macey Dr T. St Pierre Physical science

Reactive iron deposits in hum an disease Standard Project starting in 1994 941233 50,121.69 Yes Yes

Royal Perth Hospital Dr P. Leedman Endocrinology Mechanisms by which thyroid horm one controls

pituitary hormone production Standard Project starting in 1994 940770 60,941.56 Yes Yes

Prof. J. Millar Medicine The nature of insulin resistance in hypertension and obesity

Standard Project starting in 1994 940126 48,914.70 Yes No

Dr C. Witt Dr L. Abraham Clinical Immunology Im proved matching for bone marrow grafting

Standard Project continued from 1992 920603 42,778.73 No No

179

REGKEY

$

Future supoport 1995 1996

Sir Charles G airdner Hospital Dr A. James Pulmonary Physiology The measurement of inflammation and tissue dam age in the airways of asthmatics Standard Project starting in 1994 940241 43,990.00 Yes Yes

Dr R. Price Dr G. Kent Prof. J. Sikorski Mr E. Scull Endocrinology Structural changes in bone leading to hip fractures Standard Project continued from 1993 930239 31,217.00 No No

Dr T. Ratajczak Endocrinology Proteins involved in steroid hormone action Standard Project starting in 1994

A/Prof. B. Robinson Dr H. Bielefeldt-Ohmann Medicine Heat shock proteins and the hum an lung Standard Project starting in 1994

University of Western Australia Dr V. Alder Dr D- Yu Dr S. Cringle Surgery Control of blood flow and oxygen supply in normal and diseased eyes Standard Project continued from 1993

Dr E. Baker Prof. E. Morgan Physiology Therapeutic potential of iron chelating agents

Standard Project continued from 1992

Dr L. Beazley Psychology The formation of nerve connections Standard Project continued from 1992

941219 79,613.82 Yes Yes

941220 39,771.63 Yes Yes

930116 221,798.60 Yes Yes

920282 149,898.70 Yes Yes

111,222.90 Yes Yes

180

920791

REGKEY

$

Future supoport 1995 1996

U n iv e rs ity o f W estern A u stra lia cont.

Dr M. Beilharz Dr C. Lai Microbiology Genetic engineering to improve interferon use in

cancers and viral diseases Standard Project continued from 1992 920978 101,220.93 No No

Dr H. Bielefeldt-Ohmann Dr D. Fitzpatrick A /Prof. B. Robinson Medicine

How interferon rescues anti-cancer immune defences to shrink mesothelioma tum ours Standard Project starting in 1994 940173 89,339.04 Yes Yes

Dr T. Chirila Prof. I. Constable Lions Eye Institute Artificial vitreous Standard Project starting in 1994 940707 45,007.90 Yes Yes

Mr J. Chleboun Prof. A. House A /Prof. W. Castleden Surgery The role of aspirin after arterial surgery

Standard Project continued from 1993 930715 31,053.44 No No

Dr S. Collin Dr L. Beazley Psychology Additions or loss of neural connections

involved in vision during growth Standard Project starting in 1994 940720 42,594.84 Yes Yes

Prof. T. Davis Medicine Studies of blood glucose and lactic acid levels in severe malaria

Standard Project starting in 1994 940279 55,356.80 Yes Yes

181

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Future supoport 1995 1996

U niversity of Western Australia cont.

Dr N. Dc Klerk Prof. A. Musk A /Prof. M. Hobbs Public Health Asbestos-related disease in former asbestos workers from wittenoom Standard Project continued from 1992

Dr S. Dunlop Psychology The formation of axonal pathways in the developing brain Standard Project starting in 1994

Dr H. Farrell Microbiology Identification of the cytomegalovirus genes responsible for causing disease Standard Project starting in 1994

Dr D. Fitzpatrick Dr H. Biclefeldt-Ohmann A /Prof. B. Robinson Medicine Inhibiting the uncontrolled growth of mesothelioma tumours Standard Project starting in 1994

A /Prof. R. Goldie Dr P. Rigby Pharmacology Influence of inflammation on airway responses to drugs Standard Project continued from 1992

Dr M. Grounds Pathology Identification of skeletal muscle precursor cells and factors controlling regeneration Standard Project starting in 1994

920600 83,002.28 No No

940693 97,355.75 Yes Yes

941248 51,840.39 Yes No

940729 50,829.39 Yes Yes

920070 146,314.09 Yes Yes

941266 147,034.18 Yes Yes

182

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Future supoport 1995 1996

U n iv e rs ity o f W estern A u stra lia cont.

A /Prof. J. Hall Dr R. McCauley Dr K. Christiansen DrW. Erber Surgery

Amino acid therapy and bacterial leakage from the gut Standard Project continued from 1993

Dr A. Harm an Dr L. Beazley Psychology The development of the retinal pigment

epithelium in the eye of man and animals Standard Project starting in 1994

A /Prof. P. Hartm ann Dr R. Owens Biochemistry Control of breast milk synthesis and the

measurement of breast volume Standard Project starting in 1994

Dr A. Harvey Anatomy and H um an Biology Stimulating the regeneration of injured nerve pathw ays in the brain

Standard Project continued from 1992

Dr P. Henry A /Prof. R. Goldie Pharmacology Mechanism of endothelin-induced contraction in airway smooth muscle Standard Project starting in 1994

A /Prof. M. Hobbs Dr K. Jamrozik Dr P. Thompson Public Health

Monitoring trends and determinants of cardiovascular disease Standard Project continued from 1993

930722 64,137.31 Yes No

940278 76,287.78 Yes Yes

940233 45,411.69 Yes Yes

920787 81,668.76 Yes Yes

940797 83,386.46 Yes Yes

930741 123,939.07 Yes No

183

RECKEY Future supoport

$ 1995 1996

U n iv e rs ity o f Western A ustralia cont.

Prof. P. Holt Microbiology Studies on lung dendritic cells Standard Project starting in 1994 940694 173,713.86 Yes Yes

Prof. A. House Mr R. Bell Mr J. Chleboun Prof. F. Mastaglia Surgery Stroke risk in peripheral vascular disease Standard Project starting in 1994 940309 32,207.43 Yes Yes

Dr M. Hum phrey Prof. I. Constable Lions Eye Institute New procedures for delaying the onset of inherited blindness Standard Project continued from 1993 930093 42,118.99 Yes No

Dr S. Klinken Biochemistry Genes that control blood cell production Standard Project continued from 1993 930098 77,012.29 Yes No

Prof. L. Landau Dr W. Macdonald A /Prof. J. Newnham Dr S. Evans Research The antecedents of lower respiratory illness in preschool children Standard Project continued from 1993 930745 94,970.98 Yes Yes

Dr W. Langdon Biochemistry The role of a cancer-causing gene in regulating the growth of cells Standard Project continued from 1993 930614 42,300.51 Yes No

184

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Future supoport 1995 1996

U n iv e rs ity o f W estern A u stra lia cont.

A /Prof. P. Le Souef Dr J. Goldblatt Dr W. Cookson Paediatrics

How do genes involved with asthma act in early life? Standard Project continued from 1993 930094 57,582.22 Yes No

A/Prof. P. Le Souef Prof. L. Landau Paediatrics How does asthm a begin in infancy and early

childhood? Standard Project starting in 1994 941222 43,180.40 Yes Yes

A /Prof. P. Le Souef Paediatrics A new test for m easuring lung function in asthmatic infants: the pum p and squeeze method

Standard Project starting in 1994

Dr J. Mamo Prof. T. Redgrave Physiology Dietary cholesterol metabolism and its

relationship to vascular disease Standard Project continued from 1992

Dr J. Mamo Physiology Lipoprotein lipid uptake by blood vessels Standard Project starting in 1994

A/Prof. P. Martin Psychology An investigation of w hat triggers headaches and how triggers cause headaches Standard Project starting in 1994 941125 21,484.46 Yes No

941239 39,140.26 Yes Yes

920119 49,105.10 No No

940308 41,426.74 Yes Yes

185

REGKEY $

Future supoport 1995 1996

U n iv e rs ity o f Western A u stra lia cont.

Dr P. McMenamin Anatomy and Human Biology Immunocompetent cells in the anterior segment of the eye Standard Project continued from 1993 930717 48,001.07 Yes No

Dr R. Minchin Pharmacology Gene delivery to specific tissues in whole animals Standard Project continued from 1993 930718 42,118.99 Yes No

Prof. E. Morgan Physiology Interactions between iron and toxic trace metal transport into the brain Standard Project continued from 1993

Dr B. Mortimer Prof. T. Redgrave Physiology How genes regulate the body's handling of dietary cholesterol Standard Project continued from 1993

Prof. C. Oxnard Anatomy and Human Biology Engineering studies of hum an spongy bone: application to osteoporosis Standard Project continued from 1993

Prof. T. Palmer Biochemistry Recovery from strenous exercise in diabetes Standard Project starting in 1994

Dr R. Prince Medicine Why do bones get thin after the menopause? Standard Project continued from 1993

930077 ' 48,203.19 Yes No

930076 85,993.10 Yes No

930209 74,194.85 Yes No

940307 46,785.39 Yes Yes

930710 43,604.98 Yes No

186

REGKEY $

Future supoport 1995 1996

U n iv e rs ity of Western A ustralia cont.

Prof. T. Redgrave Dr I. Martins Physiology Cell uptake of chylomicron remnants Standard Project starting in 1994 940821 48,405.16 Yes Yes

Dr P. Sly Clinical Science Response of the peripheral lung to challenges

Standard Project starting in 1994 941252 111,487.86 Yes Yes

Mr M. Stacey Surgery The role of topical platelet derived growth factor in the healing of chronic venous ulcers

Standard Project starting in 1994 941254 40,606.01 Yes Yes

Dr G. Stewart Prof. P. Holt WA Research Inst for Child Health Does the chemical activity of an allergen promote asthma Standard Project continued from 1993 930746 109,160.44 Yes Yes

Mr N. Swanson Prof. W. Reed Medicine Characterisation and role of a target autoantigen

in chronic active hepatitis Standard Project continued from 1992 920391 74,203.74 No No

Dr W. Thomas Division of Molecular Biology Inhibition of im m une responses by feeding antigen Standard Project starting in 1994 940311 44,339.43 Yes Yes

Dr W. Thomas Molecular Biology Laboratory Nature of house dust mite allergens Standard Project starting in 1994 941259 161,151.73 Yes Yes

187

REGKEY

$

Future supoport 1995 1996

U n iv e rs ity of Western A ustralia cont.

Mr D. Wood Dr M. Zheng Prof. J. Papadimitriou Surgery Regulation of bone resorbing cells by hormones and local factors Standard Project starting in 1994 941251 73,645.04 Yes Yes

A /Prof. G. Yeoh Physiology Does alcohol increase the likelihood of liver cancer by producing more susceptible cells? Standard Project continued from 1992 920063 121,696.09 Yes Yes

A /Prof. G. Yeoh Physiology Use of a genetically manipulated mouse model to study onset of liver cancer Standard Project starting in 1994 941253 41,306.43 Yes Yes

Western A u stra lia n Research In s titu te fo r C h ild H ealth Ltd Dr D. Coombe Dr C. Sanderson Cell Biology How is blood eosinophil production regulated Standard Project starting in 1994 940692 45,803.71 Yes Yes

Prof. P. Holt Mr M. Schon-Hegrad Dr P. McMenamin Dendritic cells in respiratory mucous membranes Standard Project continued from 1992 920741 53,817.53 No No

Prof. P. Holt Dr C. McMenamin Dr P. Sly Control of allergic sensitisation to airborne environmental allergens Standard Project continued from 1993 930716 139,447.26 Yes No

Dr U. Kees Regulation of immature cells in the thymus Standard Project continued from 1993 930844 60,128.21 Yes No

188

REGKEY

$

Future supoport 1995 1996

Western A u stra lia n Research In s titu te fo r C h ild H ealth Ltd cont.

Dr C. Sanderson Cell Biology Molecular mechanisms in the development

of asthma Standard Project starting in 1994 940123 98,550.16 Yes Yes

Dr P. Sly The restraining influence of the chest wall on the lungs of children Standard Project continued from 1993 930723 32,993.92 No No

Dr P. Sly Allergic response in lung tissue to inhaled allergen Standard Project continued from 1993 930729 38,570.40 Yes No

Prof. F. Stanley Maternal and child health data base and congenital malformations epidemiology Standard Project continued from 1991 911113 229,693.64 Yes No

189

TASMANIA

REGKEY Future supoport

1995 1996 $

U n iv e rs ity o f Tasmania Prof. M. Clark A /Prof. E. Colquhoun Dr S. Rattigan Biochemistry Studies on the cause of diabetes and obesity Standard Project continued from 1992 921081 90,137.76 No No

Prof. M. Clark A /Prof. E. Colquhoun Biochemistry Biochemistry of working vascular tissue Standard Project continued from 1993 930165 37,298.74 Yes No

Prof. I. Jones Dr D. Hay Dr B. Mo wry Psychiatry Inheritance of severe psychiatric illness Standard Project continued from 1993 930191 82,086.43 Yes No

Dr S. Kirov Pathology Attachment to the gut by summer-diarrhoea causing bacteria Standard Project starting in 1994 940376 43,976.28 Yes Yes

Prof. H. Muller Dr G. Dandie Pathology Effects of cancer agents on migration of skin defence cells Standard Project continued from 1992 921011 88,510.07 No No

Dr J. Sallis Biochemistry Restricting kidney stone formation by giving peptide prodrugs of phosphocitrate orally Standard Project starting in 1994 940383 32,866.35 Yes No

190

REGKEY $

Future supoport 1995 1996

U n iv e rs ity o f Tasmania cont.

Prof. N. Saunders Dr K. Dziegielewska Physiology Glycoproteins in the developing brain Standard Project starting in 1994 940870 36,896.25 Yes Yes

Dr A. West Molecular Biology Laboratory Characterization of hum an metallothionein genes Standard Project continued from 1993 930850 38,258.12 Yes No

AUSTRALIAN CAPITAL TERRITORY A u stra lia n N a tio n a l U n iv e rs ity Dr F. Bygrave Biochemistry

How horm ones regulate the secretion of bile Standard Project continued from 1993 930946 73,178.70 Yes No

Dr S. Chung Dr J. Broomhead Physiology Effects of heavy metal ions on the genesis of

epilepsy Standard Project continued from 1991 910654 106,892.15 Yes No

Dr 1. Clark Science Locating origins of proteins central to malarial im m unity and pathology

Standard Project continued from 1992 920206 41,020.05 No No

Dr 1. Clark Biochemistry Mechanisms of vaccination failure and anaemia in malaria

Standard Project continued from 1993 931284 125,791.65 Yes Yes

191

RECKEY $

Future supoport 1995 1996

A u stra lia n N ational U n iv e rs ity cent.

Dr L. Dalgarno Dr R. Weir Dr I. Marshall Biochemistry Molecular studies on mosquito-borne viruses Standard Project continued from 1992

Dr L. Dalgarno Dr R. Russell Dr R. Weir Entomology Growth of ross river virus in mosquitoes Standard Project continued from 1993

Dr L. Dalgarno Dr R. Weir Biochemistry A study of how murray valley encephalitis virus causes disease in mice Standard Project starting in 1994

Dr R. Martin Zoology Effect of oxygen lack on the brain Standard Project continued from 1993

U n iv e rs ity of Canberra Dr D. Saint Prof M. Irving Animal Science The m ode of action of antiarrythmic drugs

Standard Project continued from 1992

Woden V alley H ospital

Dr C. Simeonovic Dr J. Wilson Clinical Science Reversal of autoimmune-induced diabetes in nod mice by pig proislet xenotransplantation Standard Project starting in 1994

921099 59,762.01 Yes Yes

930947 44,140.19 Yes No

940916 58,405.43 Yes Yes

930920 5,598.70 Yes No

921096 56,568.77 No No

941172 32,772.44 Yes No

192

REGKEY

$

Future supoport 1995 1996

Woden Valley H ospital cont. Dr H. Warren Cancer Research Unit Molecular interactions for the development of

human natural killer cells Standard Project continued from 1992 920447 120,546.96 Yes Yes

Dr H. Warren Dr C. Parish Cancer Research Unit A new molecule im portant in cell to cell adhesion

by white blood cells Standard Project continued from 1993 930003 44,940.27 Yes No

Dr D. Willenborg Dr G. Danta Neurosciences New approaches to inhibit inflammation in the

central nervous system Standard Project continued from 1992 920130 108,612.36 Yes Yes

NORTHERN TERRITORY M enzies School o f H e a lth Research Dr B. Currie

Mr C. Burns Dr J. Currie Research Evaluating the use of harm reduction and aversion

strategies for petrol sniffers Standard Project starting in 1994 940835 53,292.73 Yes No

Prof. D. Kemp Dr J. Keen Research U nderstanding a gene that makes malaria lethal Standard Project continued from 1993 930114 81,182.77 Yes No

193

RECKEY $

Future supoport 1995 1996

Prof. D. Kemp Dr K. Sriprakash Dr A. Haase Parasitology Genetic differences between streptococci that do

and do not cause kidney disease Standard Project starting in 1994 940722 41,136.31 Yes Yes

Prof. J. Mathews Prof. D. Kemp Dr L. Asche Dr B. Currie Research Bacteria causing respiratory disease-carriage, tolerance and treatment effects Standard Project starting in 1994 940834 38,747.59 Yes Yes

SPECIAL INITIATIVE GRANTS 1994 A boriginal H ealth Queensland In stitu te o f M edical Research

Dr P. Brindley A /Prof. P. Prociv Tropical Health Human roundworm parasite biology and diagnosis Special Initiative Grant starting in 1994 941021 44,141.67 Yes Yes

U n iv e rs ity of A delaide Dr A. Somogyi Prof. F. Bochner

Dr A. Gross Clinical Pharmacology Do Australians of different ethnic groups handle medicines similarly?

Special Initiative Grant continued from 1992 920677 61,320.21 No No

194

REGKEY $

Future supoport 1995 1996

M urdoch U n iv e rs ity A/Prof. R. Thom pson A /Prof. J. Wetherall Dr J. Reynold son

Molecular Genetics & Animal Disease Studies on the intestinal pathogen giardia in aboriginal com m unities Special Initiative G rant starting in 1994 941235 42,317.43 Yes Yes

A u stra lia n N a tio n a l U n iv e rs ity

Prof. S. Serjeantson Hum an Genetics Unit The molecular characterization of transplantation antigens in Aborigines

Special Initiative G rant continued from 1992 921069 45,155.42 No No

M enzies School o f H e a lth Research Dr K. Sriprakash Molecular Genetics Laboratory Structure of streptococcal surface proteins and role

in kidney disease Special Initiative G rant continued from 1992 920977 55,079.18 No No

Dr W. Hoy Prof. J. Mathews Dr D. Pugsley Dr D. McCredie

Research How do we stop the growing epidemic of kidney renal failure in Aboriginals Special Initiative G rant continued from 1992 921134 116,861.56 No No

Alcohol a n d su b sta n c e a b u s e U n iv e rs ity o f N ew S outh Wales A /Prof. I. Neering Physiology and Pharmacology

Mechanism of addiction to opioids using nerve cells in culture Special Initiative G rant continued from 1992 920236 47,515.06 No No

Dr J. Wilson A /Prof. R. Pirola Medicine How does alcohol dam age the pancreas? Special Initiative G rant continued from 1992 920703 51,934.40 No No

Alcohol a n d su b stan ce a b u s e cent.

REGKEY

$

Future supoport 1995 1996

U n iv e rs ity o f N ew South Wales

Prof. R. Finlay-Jones Psychiatry Antisocial personality disorder and intravenous drug use Special Initiative Grant starting in 1994 941286 77,553.56 Yes Yes

U n iv e rs ity o f Sydney A /Prof. J. Saunders Dr J. Whitfield Drug and Alcohol Services An international study of new blood tests to detect alcohol abuse Special Initiative Grant continued from 1993

U n iv e rs ity o f Queensland

Dr S. Worrall Dr P. Wilce Biochemistry Possible reasons for liver dam age in long-term alcohol abuse Special Initiative Grant starting in 1994

The F linders U n ive rsity of South A ustralia A /Prof. P. Hall Dr J. Plummer

Dr M. Ahern Dr A. Ilsley Histo pathology Drugs and toxins that increase the risk of alcohol-associated liver injury Special Initiative Grant continued from 1992

U n iv e rs ity o f Western A ustralia Prof. T. Palmer Biochemistry Mechanisms in alcohol related malnutrition Special Initiative Grant starting in 1994

930423 33,616.86 Yes No

941175 55,884.39 Yes Yes

920248 37,070.36 No No

940282 40,864.01 Yes Yes

196

REGKEY Future supoport

__________________________________________________________ $_____________1995 1996

AIDS A u stra lia n N a tio n al U n iv e rs ity Dr I. Ramshaw Cytogenetics

Immunity and virus infections Special Initiative G rant continued from 1992 921077 42,239.57 No No

A sthm a U n iv e rs ity o f N ew South Wales Dr A. Collins Microbiology and Immunology

The effect of dietary antibodies on the immune system Special Initiative G rant continued from 1992 920227 45,961.39 No No

Dr E. Burcher Physiology and Pharmacology Functions of neuropeptide in the lung Special Initiative G rant continued from 1992 921135 23,973.39 No No

D eakin U n iv e rs ity Prof. M. Howden Dr D. Hill Biological Science

How inhaled proteins from mites and pollens trigger allergic asthm a attacks Special Initiative Grant continued from 1992 920812 40,621.61 No No

U n iv e rs ity o f M elb o u rn e

Dr R. O'Brien Dr W. Thomas Medicine Immune abnormalities in respiratory disease due

to house dust mite allergy Special Initiative Grant continued from 1992 920882 36,508.55 No No

U n iv e rs ity of Western A ustralia Dr H. Mitchell A /Prof. M. Sparrow Physiology

Lung size and sensitivity Special Initiative Grant continued from 1992 920293 39,676.06 No No

197

REGKEY Future supoport

$ 1995 1996

B reast a n d p ro s ta te cancer U n iv e rs ity of Sydney

Dr B. Morris Dr A. Schrader Molecular Biology Laboratory Control of a gene highly expressed in prostate tum our cells Special Initiative Grant starting in 1994 940004 44,763.39 Yes Yes

U n iv e rs ity of Sydney Dr E. Dclikatny Dr D. Rideout Dr C. Mountford Cancer Medicine

Lipid and carbohydrate changes induced by anticancer drugs Special Initiative Grant starting in 1994 940630 70,789.57 Yes Yes

Prof. C. Tennant A/Prof. R. Smith Dr M. Kossoff D rM .Jones Psychiatry Stress factors in breast cancer Special Initiative Grant starting in 1994 940687 52,912.20 Yes Yes

Peter M acC allum Cancer In stitu te Dr D. Dorow Dr T. dc Krctscr Dr R. Simpson Molecular Sciences Group Studies on a novel family of enzymes from

human epithelia Special Initiative Grant continued from 1993 931280 45,756.08 Yes No

U n iv e rs ity o f A delaide Dr E. Cleary Dr V. Franzon Dr J. Kumaratilake Dr E. Vernon-Roberts Pathology How new blood vessels and special types of collagen are formed within breast cancers Special Initiative Grant starting in 1994 940286 45,774.39 Yes Yes

198

REGKEY

$

Future supoport 1995 1996

The F linders U n iv e rs ity o f South A u stra lia Dr W. Tilley Dr J. Bentel Surgery Control of prostate cancer growth by vitamins and hormones

Special Initiative G rant continued from 1993 931113 51,819.65 Yes No

B eh av io u ral M edicine U n iv e rs ity o f Sydney Dr P. Langeluddecke Prof. C. Tennant

Mr M. Jones Prof. S. H unyor Psychiatry Relationship of psychological stress to cardiac

arrythmia and sudden death Special Initiative G rant continued from 1992 920421 50,879.76 No No

D entistry a n d D ental Services U n iv e rs ity of Sydney Prof. Y. Mai A/Prof. R. Bryant

Mechanical Engineering Adaptation, fracture and wear of dental composite resin restorations Special Initiative Grant continued from 1992 920909 33,599.84 No No

Prof. I. Klineberg Dr G. Murray Dentistry The influence of the teeth on jaw joint

movement in hum ans Special Initiative Grant continued from 1992 920910 36,236.61 No No

Mr J. Ironside Dr T. Mori Prof. M. Swain Dentistry Biocompatible and aesthetic crowns

Special Initiative Grant continued from 1993 930437 26,801.40 Yes No

199

REGKEY $

Future supoport 1995 1996

D entistry a n d D ental Services cant.

U n iv e rs ity o f Adelaide

Dr A. Rogers Dentistry Studies on bacteria associated with destructive gum disease in humans Special Initiative Grant continued from 1993 930452 30,195.19 No No

Dr L. Richards A/Prof. G. Townsend Dr G. Tansley Dr P. Telfer Dentistry The causes of wear of the teeth Special Initiative Grant continued from 1993 930458 27,213.93 Yes No

M enopausal H ealth '

U n iv e rs ity of Queensland Prof. M. Eadie Dr R. Dickinson Dr W. Hooper Medicine Optimising the drug treatment of epilepsy Special Initiative Grant continued from 1993 930341 68,703.73 Yes No

In s titu te o f M edical and Veterinary Science Dr H. Morris Dr T. Durbridge Dr A. Need Clinical Chemistry

Finding the basis of rapid bone loss at the menopause Special Initiative Grant continued from 1993 930900 40,279.31 Yes No

S ir Charles G airdner H ospital Dr D. Gutteridge Dr R. Price Dr R. Will Diabetes and Endocrinology Menopausal osteoporosis — treatment roles of hormones and vitamin D Special Initiative Grant starting in 1994 941262 57,776.58 Yes Yes

2 0 0

Public a n d P rev en tiv e H ealth

REGKEY

$

Future supoport 1995 1996

U n iv e rs ity o f Newcastle

Dr A. Girgis Dr S. Redman Prof. R. Sanson-Fisher Prof. A. Reid

Behavioural Medicine Health record of preventive behaviours Special Initiative Grant continued from 1992 920920 58,588.20 No No

Royal C h ild re n 's H ospital Research Foundation Dr A. Catto-Smith Dr G. Barnes Gastroenterology The role and effects of mast cells in the stomach

Special Initiative Grant continued from 1992 920537 16,907.30 No No

Queensland In s titu te o f M edical Research Dr D. McManus Dr W. Tiu Dr S. Liu

Molecular Helminthology Molecular studies on the Asian blood fluke Special Initiative Grant continued from 1992 920964 58,398.05 No No

U n iv e rs ity o f Queensland A /Prof. P. Prociv Dr J. Opdebeeck Dr J. Croese

Parasitology Molecular biology to help unravel dogs' disease Special Initiative Grant continued from 1992 921117 41,205.73 No No

R ehabilitation U n iv e rs ity of Queensland Dr J. Wynne

Mrs R. Sapsford Dr N. Saines A /Prof. I. Jones Surgery

Does perineal weakness from childbirth recover? Special Initiative Grant continued from 1992 920191 42,239.57 No No

201

PRIMING GRANTS 1994 REGKEY Future supoport

1995 1996 $

NEW SOUTH WALES Royal Alexandra H ospital fo r C h ild re n Dr C. Cowell Dr M. Bellemore Endocrinology Effects of growth factors on bone Priming Project Grant continued from 1992 920432 38,539.99 No No

Royal N o rth Shore H ospital Dr J. Ryan Human Reproduction Unit Factors affecting the metabolism of embryos Priming Project Grant continued from 1992 920450 40,607.67 No No

Rozelle H o sp ita l A /Prof. J. Snowdon Mrs P. Liddell Psychogeriatric Use of tranquillisers, sedatives and antidepressants in nursing homes Priming Project Grant continued from 1993 930909 36,355.62 No No

Royal Prince A lfre d H ospital Sr M. McGill Ms P. Hoskins Endocrinology How should diabetic complications be discussed with patients?

Priming Project Grant continued from 1992 920040 34,450.85 No No

St. Vincent's H ospital, Sydney Dr P. Macdonald Clinical Pharmacology The behaviour of diseased hum an coronary arteries

Priming Project Grant continued from 1992 920637 28,169.88 No No

U n iv e rs ity o f Newcastle Dr P. Brent Clinical Pharmacology New and unique animal model of dystonia Priming Project Grant continued from 1993 930358 37,280.13 Yes No

2 0 2

REGKEY

$

Future supoport 1995 1996

Dr P. Hazell Psychiatry Mental effort in disorders of attention in children Priming Project Grant continued from 1992 920385 36,658.49 No No

U n iv e rs ity o f N ew South Wales Dr A. Bye Dr K. Chee Neurology Effect of drugs on neonatal fits monitored by video

and brainw ave analysis Priming Project Grant continued from 1992 920228 33,598.88

Dr G. Marshall Leukemia Research & Viral Pathology An investigation of the cause of the childhood cancer, neuroblastom a

Priming Project Grant starting in 1994 940944 46,785.39

Prof. C. McGilchrist Statistics Allowing for patient frailty when assessing

risk factors for survival Priming Project Grant continued from 1993 930530 39,213.53

U n iv e rs ity of S ydney Dr M. Allman Human Nutrition Vegetable omega 3 fatty acids and heart

disease risk factors Priming Project Grant starting in 1994 940014 39,770.79

Dr J. Brand Miller Dr P. McVeagh Biochemistry The digestion of complex sugars of hum an milk

Priming Project Grant continued from 1993 930623 45,180.33

Dr H. Jeffery Fetal Medicine The development of coordinated breathing and swallowing in preterm infants

Priming Project Grant continued from 1992 920837 35,181.90

No No

Yes Yes

Yes No

Yes Yes

Yes No

No No

203

REGKEY $

Future supoport 1995 1996

U n iv e rs ity of Sydney cont.

Dr C. Lid die Gastroenterology Control of human liver enzymes by hormones Priming Project Grant starting in 1994 940026 44,279.61 Yes Yes

Dr H. Lloyd Pharmacology Understanding how the brain can survive after a stroke Priming Project Grant continued from 1993 930039 25,454.31 Yes No

U n iv e rs ity of W ollongong Dr J. Carver Chemistry U nderstanding the mechanism of human cortical contact

Priming Project Grant continued from 1992 920617 ' 31,517.21 No No

Westmead H ospital Dr W. Rawlinson Virology Study of HCMV (A Herpes virus) and how it multiplies — aiming to reduce its impact on AIDS Priming Project Grant continued from 1993 930073 40,432.60 Yes No

VICTORIA

D eakin U n ive rsity Dr M. Morris Biological Science Brain mechanisms of blood pressure control Priming Project Grant continued from 1992 920156 23,415.31 No No

U n iv e rs ity o f M elbourne Dr C. Anderson Cell Biology How the autonomic nervous system is organised in the spinal cord Priming Project Grant continued from 1992 920154 40,688.80 No No

204

REGKEY $

Future supoport 1995 1996

U n iv e rs ity of M e lb o u rn e cont.

A /Prof. P. Morris Psychiatry A study of the brain dam age and brain chemistry characteristics of depressed mood after stroke

Priming Project G rant starting in 1994

QUEENSLAND

940064 21,158.71 Yes Yes

Queensland In s titu te of M edical Research Dr A. Suhrbier Tropical Health The role of im m une cells in ross river disease

Priming Project Grant starting in 1994 941148 39,632.01 Yes Yes

Queensland U n iv e rs ity o f Technology Dr P. Giffard Dentistry Analysis of a surface component of a microbe that

causes tooth decay and gum disease Priming Project Grant continued from 1992 920951 44,286.57 No No

U n iv e rs ity o f Queensland Dr P. Colditz Perinatal Medicine A study of some causes of brain dam age in

preterm infants Priming Project Grant continued from 1992 920322 34,232.67 No No

Dr J. Curlewis Physiology and Pharmacology Control of horm one levels by the brain Priming Project Grant continued from 1993 930240 39,268.72 Yes No

Dr P. McCombe Medicine Recurrences of demyelinating disease Priming Project G rant continued from 1992 921139 28,551.80 No No

Dr A. Symons Dentistry The molecules involved in regulating tooth eruption and development

Priming Project Grant continued from 1992 920755 40,621.61 No No

205

REGKEY Future supoport

$ 1995 1996

SOUTH AUSTRALIA U n iv e rs ity of A delaide Dr L. Bignold Pathology

Movements of white blood cells in arthritis Priming Project Grant continued from 1992 920696 44,740.79 No No

Dr J. Trahair Anatomy and Histology How ingestion before birth benefits development of the gut

Priming Project Grant continued from 1992

The F linders U n iv e rs ity o f South A ustralia A /Prof. J. Crawford

920682 36,110.57 No No

Psychology Assessment and modelling of frontal lobe dysfunction · Priming Project Grant starting in 1994 940758 40,943.28 Yes Yes

Dr U. Mueller O bstetrics/ Gynaecology Detection of Down's Syndrome from a blood sample of a pregnant woman Priming Project Grant continued from 1992 920660 45,341.08 No No

Dr D. Wattchow Prof. M. Costa Physiology The nervous system of the hum an gut in health and disease Priming Project Grant continued from 1992 920165 22,149.89 No No

R oyal A d e la id e H ospital Dr P. Hoban A /Prof. A. Beddoe Medical Physics Accurate radiotherapy dose calculations Priming Project Grant starting in 1994 940650 23,965.98 Yes No

206

PROGRAM GRANTS 1994 REGKEY Future supoport

__________________________________________________________ $_____________1995 1996

NEW SOUTH WALES Centenary In s titu te o f Cancer M e d icin e and C ell B io lo g y Prof. A. Basten Dr R. Scollay

Clinical Immunology Cellular and molecular aspects of im m une respones Program Grant continued from 1991 913222 673,477.57 Yes No

U n iv e rs ity of N ew South Wales Prof. C. Chesterman A/Prof. B. Chong Haematology The function of the blood and blood vessel

which maintains blood fluidity Program Grant starting in 1994 943213 460,000.97 Yes Yes

U n iv e rs ity o f S ydney

Prof. G. Johnston Dr R. Allan Pharmacology Neurochemical pharmacology of synaptic transmission in the brain

Program Grant continued from 1991 913211 463,991.87 Yes No

VICTORIA

A u s tin Research In s titu te

Prof. I. McKenzie Dr P. Hogarth Pathology Studies in cell surface antigens by hybridoma

and other techniques Program Grant continued from 1991 913224 879,780.68 Yes No

Prince H enry's In s titu te of M edical Research Prof. H. Burger A/Prof. J. Findlay Reproductive Medicine

Hormones and the control of fertility Program Grant starting in 1994 943208 721,808.17 Yes Yes

207

REGKEY Future supoport

$ 1995 1996

R oyal M elbourne In s titu te of Technology Prof. D. Story Dr J. Reid Medical Laboratory Science Modulation of synaptic transmission by prejunctional and postjunctional mechanisms Program Grant continued from 1993 933212 264,307.26 Yes Yes

U n iv e rs ity o f M e lbourne Prof. J. Furness Dr J. Bornstein Physiology Structure, neurochemistry and function of the enteric nervous system Program Grant continued from 1992 923211 437,071.01 Yes Yes

Dr J. Hamilton Dr I. Campbell Medicine Towards an understanding of leukemia and arthritic disease Program Grant continued from 1993 933210 629,896.86 Yes Yes

Prof. R. Larkins Dr J. Proietto Medicine Studies on the pathogenesis and complications of diabetes mellitus Program Grant continued from 1992 923210 502,478.77 Yes Yes

Prof. T. Martin Dr D. Findlay Medicine Hormonal & cellular regulation of bone resorption & formation Program Grant continued from 1992 923214 534,442.98 Yes Yes

QUEENSLAND

Q ueensland In s titu te o f M edical Research Dr D. Moss Dr T. Sculley Tropical Health

Epstein-Barr virus in hum an disease Program Grant continued from 1993 933207 450,261.16 Yes Yes

208

REGKEY Future supoport

_____________________________________ $ 1995 1996

Prof. L. Powell Prof. J. Halliday Medicine Iron metabolism and liver disease

Program Grant continued from 1991

Dr A. Saul A/Prof. M. Good Immunology Malaria and vaccine research

Program Grant starting in 1994

SOUTH AUSTRALIA A delaide C h ild re n 's H ospital Prof. G. Sutherland Dr D. Callen

Cytogenetics and Molecular Genetics Understanding the mechanisms of hum an inherited diseases Program Grant starting in 1994

A delaide M e d ica l Centre fo r Women and C hildren Dr J. H op wood Chemical Pathology Diagnosis and treatm ent of genetic disorders

Program Grant continued from 1992 923209 499,304.94 Yes Yes

The F linders U n iv e rs ity o f South A u stra lia

Prof. J. Chalmers Dr I. Llewellyn-Smith Medicine The brain and blood pressure

Program Grant starting in 1994 943202 503,215.05 Yes Yes

In stitu te o f M edical and Veterinary Science Prof. M. Vadas Dr A. Lopez

Human immunology Program Grant continued from 1993 933202 880,947.96 Yes Yes

913226 534,274.87 Yes No

943201 560,397.53 Yes Yes

943210 450,045.31 Yes Yes

209

WESTERN AUSTRALIA

REGKEY $

Future supoport 1995 1996

R oyal Perth H ospital

Prof. R. Dawkins A /Prof. F. Christiansen Clinical Immunology Genetic and controlling factors important in immunological diseases Program Grant continued from 1990 903212 318,106.98 No No

U n iv e rs ity of Western A ustralia Prof. L. Beilin A /Prof. I. Puddey Medicine Studies in hypertension and vascular disease Program Grant starting in 1994 943217 429,292.52 Yes Yes

Dr D. Robertson *

Dr G. Yates Physiology Physiology and biophysics of hearing and deafness Program Grant continued from 1992 923213 313,761.75 Yes Yes

Prof. G. Shellam A /Prof. J. Mackenzie Microbiology Studies of how viruses cause disease and how

the im m une response is protective Program Grant continued from 1991 913205 586,820.28 Yes No

EQUIPMENT GRANTS 1994 NEW SOUTH WALES

C entenary In stitu te of Cancer M edicine and C e ll B iology Prof. A. Basten Dr R. Scollay Ms C. Fazekas De St. Groth Dr J. Sedgwick Research Double beam UV-VIS (190-9000NM) spectrophotometer Equipment Project starting in 1994 941329 12,000.00 No No

2 1 0

REGKEY $

Future supoport 1995 1996

C h ild re n 's M e d ica l Research In s titu te Prof. P. Rowe Dr P. Jeffrey Dr P. Gunning

Dr P. Tam Research FTS-IS FAS capillary equencer Equipment Project starting in 1994 941330 8,000.00 No No

Garvan In s titu te of M e d ica l Research Prof. J. Shine Prof. D. Chisholm Prof. J. Eisman

Prof. R. Sutherland Metabolic Unit Automated DNA sequencing system Equipment Project starting in 1994 941343 45,000.00 No No

Heart Research In s titu e

Dr K. Stanley A /Prof. G. McCaughan Molecular Biology Laboratory Phosphor image analyser BAS 1000

Equipment Project starting in 1994 941322 12,000.00 No No

M acquarie U n iv e rs ity A /Prof. J. Whalley Dr G. Lawrence Prof. K. Williams

Dr K. Emslie Biological Science C 02 incubators and lamoinar flow cabinet for virus research

Equipment Project starting in 1994 941298 5,200.00 No No

Royal Prince A lfre d H ospital Dr P. Bye Dr S. Anderson Dr G. Bautovich

Mr D. Bailey Nuclear Medicine Staf MKII spinning top aerosol generator Equipment Project starting in 1994 941320 15,140.00 No No

REGKEY $

Future supoport 1995 1996

Dr G. Halmagyi Dr I. Curthoys Mr M. Todd Neurology Silicon graphics computer additions Equipment Project starting in 1994 941321 6,000.00 No No

St. Vincent's H ospital, Sydney Prof. P. Brooks Prof. R. Day ,

Medicine Mammalian cell culture facility Equipment Project starting in 1994 941328 4,500.00 No No

U n iv e rs ity of Newcastle A /Prof. D. Powis Dr S. Bunn . '

Dr D. Van Helden A /Prof. P. Dunkley Medicine Luminescence spectrometer for fluorescence Equipment Project starting in 1994 941314 33,000.00 No No

U n iv e rs ity of N ew South Wales Dr G. Halliday Prof. E. McLachlan Medical Research Com puter — video camera system for quantitative neuropathological analyses Equipment Project starting in 1994 941300 60,429.00 No No

Dr G. Mendz Dr G. King Dr S. Hazell Biochemistry Upgrade of biomedical NMR facility at UNSW Equipment Project starting in 1994 941301 20,000.00 No No

2 1 2

REGKEY

$

Future supoport 1995 1996

U n iv e rs ity o f Sydney Prof. L. M ather Prof. M. Cousins Dr C. Duke Anaesthesia Gas-liquid chromatograph: HP system II-PC based

Equipment Project starting in 1994 941306 53,744.00 No No

Dr B. Morris Dr J. Hoh Dr W. Phillips Dr R. Mason

Physiology Orbital incubator Equipment Project starting in 1994 941307 13,278.00 No No

Prof. B. Roufogalis A /Prof. G. Holder Dr D. Cutler Dr C. Armour

Pharmacy Imaging analysis system Equipment Project starting in 1994 941308 60,000.00 No No

U n iv e rs ity of W ollongong Dr G. Wickham Dr M. Walker Dr M. Sheil

Dr M. Baker Chemistry DNA synthesizer Equipment Project starting in 1994 941325 3,700.00 No No

VICTORIA Baker M e d ica l Research In stitu te Prof. J. Funder Dr W. Anderson

Dr A. Smith Dr N. Fidge Research Phosphoimage analyser system

Equipment Project starting in 1994 941365 53,000.00 No No

213

REG KEY $

Future supoport 1995 1996

Peter M acC allum Cancer In stitu te Dr R. Martin Molecular Sciences Group Molecular graphics system Equipment Project starting in 1994 941344 4,500.00 No No

D e a kin U n iv e rs ity

Prof. K. O O ea Dr G. Collier A /Prof. D. Briggs Dr J. Muir Nutrition Ulra-cold upright freezer Equipment Project starting in 1994 941341 3,000.00 No No

H ow ard Florey In stitu te '

Prof. J. Coghlan Physiology Robotic liquid handling system and centrifuge Equipment Project starting in 1994 941364 80,000.00 No No

La Trobe U n ive rsity, V IC Prof. C. Bernard Dr N. Kerlero de Rosbo Dr T. Johns Psychology Model PS3 automated peptide synthesizer Equipment Project starting in 1994 941345 13,000.00 No No

M e n ta l H ealth Research In s titu te o f Victoria Mr B. Dean Dr D. Wan Neurosciences Olym pus microscope with photography Equipment Project starting in 1994 941362 9,000.00 No No

M u rd o ch In s titu te fo r Research in to B irth Defects Prof. D. Danks Research Tracktel image documentation system

Kodak X-OMATIC au tom atic film developer Equipment Project starting in 1994 941324 19,000.00 No No

214

REGKEY

$

Future supoport 1995 1996

M onash U n iv e rs ity Prof. M. Hearn Dr C. Handley Dr W. Comper Prof. A. Linnane Biochemistry

Low angle laser light scattering apparatus Equipment Project starting in 1994 941331 95,000.00 No No

Prince H enry's In s titu te o f M edical Research Prof. H. Burger Research Liquid scintillation counter Equipment Project starting in 1994

Royal M e lb o u rn e In s titu te of Technology Prof. D. Story Prof. M. Rand

Medical Biology Tri-carb 1900TR liquid scintillation analyser Equipment Project starting in 1994

St. Vincent's H o s p ita l, M elb o u rn e

Dr A. Stewart Prof. W. Morrison Mr A. Macleod Mr P. Hayward

Microsurgery Olympus Cue image analysis system Equipment Project starting in 1994

St. Vincent's In s titu te of M edical Research Dr M. Parker Research

Alpha workstation and terminal server Equipment Project starting in 1994

941363 29,000.00 No No

941361 20,000.00 No No

941357 6,800.00 No No

941360 9,500.00 No No

RECKEY $

Future supoport 1995 1996

U n iv e rs ity o f M elbourne Prof. R. Larkins Prof. C. Masters Dr W. Cook Dr V. Nurcombe Medicine Phosphor imager Equipment Project starting in 1994 941349 96,900.00 No No

Dr M. Lightowlers Parasitology Molecular dynamics denitometer, software and dye-sublimation printer

Equipment Project starting in 1994 941350 58,956.00 No No

Prof. W. Louis Dr E. Conway ·

Dr G. Jackman Mr T. Nero Clinical Pharmacology IRIS INDIGO XZ, a unit computer graphics workstation Equipment Project starting in 1994 941351 10,000.00 No No

W alter and Eliza H a ll In s titu te Prof. G. Nossal Electron Microscopy Unit Cryopreparation equipment for EM Biosym II software and Silicon Graphs Equipment Project starting in 1994 941342 108,000.00 No No

QUEENSLAND

Queensland In stitu te of M edical Research Dr A. Saul Dr D. Moss Prof. J. Halliday Dr P. Upcroft Research Applied Biosystem Model 373 DNA Sequencer Equipment Project starting in 1994 941388 45,000.00 No No

216

REGKEY

$

Future supoport 1995 1996

Queensland U n iv e rs ity o f Technology Dr T. Vandoorn Dr T. Barker Health Sciences Com puter Graphics Equipment for Processing and Display of Medical Images

Equipment Project starting in 1994 941384 5,000.00 No No

Royal C h ild re n 's H o sp ita l, Brisbane Dr J. Pope Prof. E. Westaway Sir Albert Sakzewski VRL

Cryotome for frozen sections Equipment Project starting in 1994 941401 7,500.00 No No

U n iv e rs ity of Queensland Dr P. Alewood Prof. P. Andrews Dr R. Brinkworth

Prof. S. Pond Drug Design and Development Pharmacia Biacore-Analysis of intermolecular interactions in drug discovery & development

Equipment Project starting in 1994 941389 60,000.00 No No

Dr J. Curlewis Dr L. Bryan-Lluka Dr D. Vaney Dr E. Hampson

Physiology and Pharmacology HPLC with Electrochemical Detection for Assay of Catecholamines Equipment Project starting in 1994 941390 45,000.00 No No

SOUTH AUSTRALIA A delaide M edical Centre fo r Women and C hildren Dr J. Pa ton Microbiology

Refrigerated Centrifuge and Gel Documentation System Equipment Project starting in 1994 941369 20,000.00 No No

REGKEY Future supoport

$ 1995 1996

U n iv e rs ity o f A delaide Dr E. Cleary Dr J. Kumaratilake Pathology Monochromated light system Equipment Project starting in 1994 941372 33,600.00 No No

Dr B. May Dr J. Wallace Dr R. Saint Dr P. Rathjen Biochemistry Heraeus Sepatech Megafuge 1.0 Equipment Project starting in 1994 941373 10,927.00 No No

The F lin d e rs U n iv e rs ity o f South A ustralia Dr P. Pilowsky Dr 1. Llewellyn-Smith Dr W. Blessing A /Prof. J. Willoughby Medicine Eutectic neuron reconstruction system Equipment Project starting in 1994 941366 40,000.00 No No

Dr J. Plummer Dr A. Ilsley A /Prof. P. Hall Dr M. Ahern Anaesthesia and Intensive Care FOXB IA-BAI Miran Air Monitor Model 1A Equipment Project starting in 1994 941367 22,000.00 No No

In s titu te o f M edical and V eterinary Science Dr L. Ashman Dr P. Simmons Dr C. Hutchins Dr T. Hughes Leukemia Research & Viral Pathology Bench Top Ultracentrifuge and Rotors Equipment Project starting in 1994 941380 33,500.00 No No

218

REGKEY $

Future supoport 1995 1996

R oyal A d e la id e H o sp ita l A /Prof. L. Cleland Dr G. Mayrhofer Research Cryostat for Preparation of Frozen Tissue Section

Equipment Project starting in 1994 941382 12,000.00 No No

WESTERN AUSTRALIA C u rtin U n iv e rs ity o f Technology

Dr K. Singer Dr P. Breidahl Mr R. Day Medical Physics

Struers Rotopol bone sample polisher for histom orphom etry Equipment Project starting in 1994 941403 6,000.00 No No

U n iv e rs ity o f Western A ustralia Dr R. Coelen Dr M. Beilharz A /Prof. J. Mackenzie

Microbiology Genbank database server, SUN SPARC station 2 Equipment Project starting in 1994 941409 25,000.00 No No

A /Prof. G. Yeoh Dr S. Klinken Dr A. Harvey Physiology

Phospor imager Equipment Project starting in 1994 941408 75,000.00 No No

Western A u stra lia n Research In s titu te fo r C h ild H ealth L td

Dr W. Thomas Dr U. Kees Molecular Biology Laboratory Type NVT65 near vertical tube rotor package

Equipment Project starting in 1994 941358 7,000.00 No No

TASMANIA

REGKEY $

Future supoport 1995 1996

U n iv e rs ity o f Tasmania Prof. M. Clark A /Prof. E. Colquhoun Dr S. Rattigan Biochemistry Diode array detector Equipment Project starting in 1994 941406 10,400.00 No No

NORTHERN TERRITORY M enzies School o f H ealth Research Prof. D. Kemp Dr K. Sriprakash Dr L. Asche Prof. J. Mathews Research *

Beckman J2-M1HS high speed centrifuge Equipment Project starting in 1994 941405 10,000.00 No No

220

M edical P o s tg ra d u a te Research S cholarships a n d D ental P o s tg ra d u a te Research S cholarships for 1994 Name and

Re%Key

Institution Title of Study

M edical First Y ear A w a rd s Dr J.R. Bessell University of Adelaide New Endosurgical procedures

948108 for the treatment of peptic

ulcer disease

Dr T.K. Blackmore Flinders University of South Construction and analysis 948109 Australia of chimeric complement

regulatory proteins

Dr W.A. Brown Monash University Vasco Endothelial growth

948111 factor in reproductive medicine

Dr M.J. Burt Queensland Institute Positional cloning of the

948113 of Medical Research haemochromatosis gene

Dr F.J. Cameron Royal Children's Correlation between intersex

948114 Hospital Research phenotype, gonadal malignancy

Foundation and the presence of the SRY gene

Dr S.B. Campbell Queensland Institute Tolerance induction in normal

948116 of Medical Research T lymphocytes

Dr R.K.M. Chan University of Melbourne Imaging modalities for the

948122 assessment of coronary artery

disease

Dr P.D. Clouston Westmead Hospital Digital stimulation and motor

948123 neuron excitability in

Parkinson's disease

Dr S.J. Cohney Austin Research Institute Production of transgenic

948124 mice as a model for

humanxenografts

221

Name and Reg Key

Institution Title of Study

M edical First Y ear A w ard s cant.

Dr A.M. Corbould Hinders University of South Alprazolam as an inhibitor 948126 Australia of central corticotropin­

releasing hormone (CRH)

Dr D.J. Curtis Walter and Eliza Disruption of the GM-CSF/IL-

948127 Hall Institute of Medical 3/IL-5 common b-chain

Research receptor gene

Dr P.J. Dawson University of Melbourne The cardiovascular actions

948130 of propofol and its use in

cardiac surgery

Dr Hooi C Ee University of Melbourne The Cdx-2homebox gene in

948133 intestinal epithelium

Dr D Eisen Monash University Protective antigens of

948134 plasmodium falciparum

Dr S.F. Fanning Queensland Institute Acute promyelocytic

948136 of Medical Research leukaemia — Pathogenesis and

resistance to retinoic therapy

Dr I.G. Faragher Ludwig Institute of The molecular genetics of

948137 Cancer Research a hereditary non-polyposis

colon cancer family

Dr J.A. Fleming Monash University Gabaa receptors modulating

948142 nociciption in the dorsal

horn of the spinal cord

Dr G.M. Forbes Royal Perth Hospital The immunopathology of

948143 gastrointestinal graft-

versus-host disease

D rJ.G .Fox Austin Research Institute The development of fully

948144 human antibodies to cancer

associated antigens

Dr D.F. Gray Royal North Shore Hospital Effects of lipids on the

948147 sarcolemmal sodium-

potassium pump

222

Institution Name and Reg Key M edical First Y ear A w a rd s c an t.

Title of Study

Dr P.J. Harvey Flinders University of South Blood pressure control 948149 Australia in prim ary hyperaldoster-onism

Dr S Sook-H eng Ho U niversity of M elbourne Single Photon Emission 948155 Com puted Tomography

(SPECT) in extratemporal epilepsies

Dr D.J. Holland University of Sydney Herpes simplex viral

948156 replication and transport

in neurones and keratinocytes

Dr R.V. Jamieson Choildren's Medical X chromosome activity in

948160 Research Institute turner syndrome and

regulation of x-inactivation

Dr L.M. Johnstone Royal Melbourne Antibodies to endothelial

948161 Hospital cells and fibroblasts in

renal transplant recipients

Dr P. Kovoor Westmead Hospital Radiofrequency ablation for

948167 ventricular tachycardia

Dr B.J. Kuss Adelaide Medical Molecular and Gene expression

948168 Centre for Women studies of the q arm breakpoint

and Children in inv(16) of M4Eo

Dr W. Lam Austin Hospital Role of supramedullary

948170 structures in cardiovascular

response to airjet stress

Dr P.S.P. Lee University of Melbourne Proatherogenic changes in the

948173 lipoprotein composition in chronic

renal failure

Dr C.R. Levi Austin Hospital Risk of cerebral ischaemia

948174 with structural cardiac and aortic

diseases

Dr D.P. Macgregor University of Melbourne Chemical neuroanatomy and 948180 hum an neuropathology

223

Name and Reg Key

Institution Title of Study

M edical First Y ear A w ard s cant.

Dr C.R. MacIntyre University of Sydney The epidemiology of

948181 microbacterium avium complex

infection in aids

Dr P.T. Morley Royal Melbourne Hospital Pathophysiology of

948184 ventilator dependence in

critical illness

Dr I.D. Norton University of New Alcohol and the pancreas

948190 South Wales

Dr Kun-Ying Pan University of Sydney Pathogenesis of urticaria

948191 investigations into RFLP of

Ige gene and molecular characterisation

Dr G.M. Patrick Queen Elizabeth Hospital T lymphocyte cytokines and 948193 and immunosuppression of

allografts

Dr M.R. Patrick Austin Research Institute The production and biological 948194 activity of engineered

monoclonal antibodies in cancer

Dr N. Petrovsky Walter and Eliza T cell responses in identical

948196 Hall Institute of Medical twins in insuline dependent

Research diabetes

Dr C.M. Pyke Queensland Institute Cell cycle anomalies in

948198 of Medical Research ataxia telangiectasia

Dr C. Rakjumar Monash University Pathogenesis of diastolic

948199 dysfunction in the elderly with

heart failure and silent myocard

Dr A.T. Reutens Garvan Institute of Oestrogen regulation of

948201 Medical Research growth hormone action in adult

humans

224

Name and Institution Title of Study

Re* Key__________________________________________________________

M edical First Y ear A w a rd s cant.

Dr E. Romas University of Melbourne Interactions between

948203 glucocorticoids and cytokines

in osteoblast function

Dr G.B. Rudy Walter and Eliza A second hum an mhc class ii

948206 Hall Institute dq molecule: biological and

clinical significance

Dr E. Segelov University of Sydney DNA repair and cisplatin

948207 sensitivity

Dr M.A. Stoodley Royal Adelaide Investigation of the patho­

948214 Hospital physiology of syrinx formation

in syringomyelia

Dr C.M. Sue Westmead Hospital Diversity of expression of

948215 mitochondrial cytopathy

Dr A.F. Tan University of Melbourne Thalamic connections for

948216 sensorimotor integration in

primates

Dr D.R. Taupin University of Melbourne The role of the trefoil

948218 peptides and peptide tyrosine

leucine am ide in gastro­ intestinal growth

Dr H.L. Thomson University of Queensland Baroreceptor function in 948220 health and disease

Dr J. Torres! MacFarlane Burnet Antibody responses following

948221 Centre for Medical

Research

hepatitis E virus infection

Dr M.A. Wake Royal Children's Tympanostomy tubes: do they

948225 Hospital Research affect young children's

Foundation language and behaviour

Dr RD. West St Vincent's Effect of antiarrhythmic

948228 Hospital,Sydney drugs on ion channels in

ischaemia

225

Name and Reg Key

Institution Title of Study

M edical Second-year renewals Dr T. Yen Heart Research Institute Regulation of cell adhesion

948233 by SI00 proteins

Dr G.N. Ali St George Hospital Afferent and efferent

938102 control of the oral-

pharyngeal swallow

Dr M.J. Arens Institute of Medical Hepatitis D (HDV) —

938101 and Veterinary Science related interference

Dr J.O. Aspinall Flinders University of The role of the androgen

938103 South Australia sensitive protein,

apolipoprotein-D, in prostate cancer

Dr S.T. Aw Royal Prince Alfred The 3 dimensional spatial

938104 Hospital properties of the hum an

vestibulo-ocular reflex

Dr R.L. Balleine University of Sydney Molecular basis of

938105 resistance to hormonal

agents in human breast cancer

Dr M.C. Bowman Royal North Shore Pelvic adhesions:

938107 Hospital aetiology, associations

and prevention

Dr F.M. Boyle Royal North Shore Prevention of cytotoxic-

938108 Hospital induced neuropathy with

glutamic acid

Dr D.G.P. Carey Garvan Institute of NIDDM and insulin

938112 Medical Research resistance: roles of liver

and muscle metabolism

Mr R.A. Danks University of Melbourne A transgenic mouse model

938124 of glioma using P53 and

SV40 large T gene constructs

2 2 6

Name and Reg Key

Institution Title of Study

M edical Second-year renewals cont. Dr M. Dziegielewski University of New Interaction of normal and

938123 South Wales m alignant epithelial cells

with extracellular matrix

Dr P.A. Foley St Vincent's Institute Vitamin D and parathyroid

938129 of Medical Research hormone-related protein

in skin keratinization

Dr K.M. Fong University of Queensland The molecular biology

938130 on non-small cell lung cancer

Dr G.S. Hebbard Royal Adelaide Hospital Mechanics and control of

938136 normal and disordered

gastric emptying

DrP.J.H o Royal Prince Alfred Regulation of insulin-

938139 Hospital like growth factor-binding

proteins

Dr D.M. Hoffman Garvan Institute of Metabolic abnormalities

938224 Medical Research in growth hormone

deficient adults

Dr D.A. Kandiah University of New Antiphospholipid

938142 South Wales antibodies and their

interaction with B2Glycoprotcin-l

Dr A.D. Kelleher University of New Study of the immune

938145 South Wales response to a HIV vaccine

Dr S.R. Lewin Macfarlane Burnet Aveolar macrophanges in

938151 Centre for Medical HIV infected patients and

Research their response to

pneumocystis carinii

Dr G.L. Ludbrook Royal Adelaide Hospital The cerebral

938156 pharmacokinetics and

pharmacodynamics of opioids

Dr M.M. Marsh Prince Henry's Institute Endothelin in the

938159 of Medical Research endometrium and its role

in menorrhagia

227

Name and Re%Key

Institution Title of Study

M edical Second-year renewals cont. Dr G .J. McColl Walter and Eliza Hall Synovial antigens in

938162 Institute of Medical Research rheumatoid arthritis

Dr A.J. McDougall University of Sydney Autonomic function in

938163 multiple sclerosis

Dr E.F. Morand Monash University Corticotrophic releasing

938165 factor and the mediation

of inflammation

Dr W.H. Morgan University of Western Pressure gradients across

938166 Australia the optic disk: a new

approach to glaucoma

Dr G.B. Napoli Royal Prince Alfred Molecular basis of chronic

938169 Hospital liver disease: role of

cytokines

Dr K.M. Newton University of Queensland Pharmacokinetics and 938170 pharmacodynamics of

central nervous system depressants

Dr K. Paizis St Vincent's Hospital Epidermal growth factor

938175 receptor signalling in

glomerulonephritis

Dr S.J. Preston Royal North Shore Methotrexate in rheumatic

938180 Hospital disease — bone and

gastrointestinal side effects

Dr J.B. Prins Princess Alexandra Determinants of regional

938181 Hospital fat distribution

Dr S.M. Riordan Prince Henry and Prince Small intestinal bacterial

938185 of Wales Hospital contamination,

malabsorption and malnutrition

Dr M. Rischmueller Flinders University of Human immune responses 938186 South Australia to the Ro(SSA) and La(SSB)

autoantigens

228

Name and Institution Title of Study

Re^Key___________________________________________________________________

M edical Second-year renewals cont. Dr A.W. Roberts University of Melbourne Quantitation of lymphoma 938187 cells in peripheral blood

progenitor cell harvests

Dr S. Rogerson Walter and Eliza Hall Resetting and

938188 Institute of Medical Research cytoadherence in

plasm odium falciparum malaria

Dr D. Samarasinghe 938192 University of Sydney Role of hepatic cell types

in ischaemia — reperfusion injury

Dr R.M. Selzer 938193

University of Melbourne Prospective study of eating disorders in a high risk population

Dr K.G.C. Smith 938194 Walter and Eliza Hall Institute of Medical Research

Cellular and molecular interaction in a humoral im m une response

Dr J. Snider 938195

Austin Research Institute Production of Fc receptors and investigation of their application in vivo

Dr L. Tian 938202

University of Sydney Role of placental MHC

and adhesion molecules in implantation of the murine embryo

Dr D.J. Torpy 938203

University of Queensland Effect of psychoactive drugs on ACTH release in humans

DrJ.W. Upham 938205

University of Western Australia T cells in asthmatic airways: allergen

specificity and cytokine production

Dr D.G. Walker 938206

Queensland Institute of Medical Research Tumour suppressor genes in astrocytoma

Name and Institution Title of Study

Second-year renewals cont. Dr M.D. Weltman University of Sydney Cytochrome p450 2el and

938210 the pathogenesis of hepatic non­

alcoholic steatonecrosis

Dr S. Whyte University of Melbourne Biochemical aspects of

938213 amyloid precursor protein

and Alzheimer's Disease

Dr N. Wilckcn Garvan Institute of Retinoids and breast

938214 Medical Research cancer

Dr K.D. Winkel Walter and Eliza Hall Dendritic cells and the

938216 Institute of Medical Research control of im m une responses

Dr K.K. Wong University of Queensland Mapping of genes which

938219 predispose to hypertension

Dr P.P. Youssef Flinders University of Mechanism of action of

938222

Third-year renewals

South Australia pulse methylprednisolone

therapy on cellular traffic

Dr A. E. Baird University of Melbourne HMPAO spect in acute

928106 ischaemic stroke

Dr J.A. Barbara Institute of Medical and The role of PAF in the

928108 Veterinary Science signal-transduction

pathway of 6M-CSF in human monocytes

Dr N. W. Cheung Westmead Hospital , Inhibitory effects of

928115 somatostatin on cell

function and proliferation

Dr A. Chrysostomou University of Melbourne Thin basement membrane 928117 disease: a study of the

aetiology pathogenesis and prognosis

Dr P. A. Cistulli Royal Prince Alfred Sleep-disordered

928119 Hospital breathing in Marfan's Syndrome

Dr P. L. Dabkowski The Austin Research Cloning of lymphocyte

928123 Institute surface antigens by COS

cell transfection

Reg Key Medic

230

Name and Institution Title of Study

M edical Third-year renewals cant. Dr P. M. Dennington Red Cross Blood Bank Studies of platelet

928124 structure & function in

platelet concentrates

Dr J. H. Erlich Monash University Dysregulation of

928129 coagulant & fibrinolytic

molecules in glomerulonephritis

Dr D. Fatkin St Vincent's Hospital Atrial fibrillation -

928130 management, complications

and mechanisms

Dr V. M. Gordon University of New South Pathways mediating

928134 Wales afferent impulses from the

cerebral vessels in the cat

Dr S. Greenaway Westmead Hospital Cellular and molecular

928135 characterisation of a

leucocyte antigen

Dr J. D. Greenstein Prince Henry Hospital, Studies of complement

928136 Sydney function in mesangial

IgA nephropathy

Dr N.S. Harley University of Melbourne The role of hyperlipidaemia

928138 in renal disorders

Mr J.R. Iredell University of Adelaide Antigenic variability in

928141 toxic co-regulated pilus of

v. cholerae

Dr G. Jones Garvan Institute of Dubbo osteoporosis

928142 Medical Research epidemiological study

Dr S. A. Koblar Walter & Eliza Hall Regulation of neural

928145 Institute of Medical differentiation

Research by growth factors

Dr Μ. N. D. Lassere St George Hospital Predictors of disease in

928148 rheumatoid arthritis

DrW. Lau Heart Research SI00 proteins in

928149 Institute inflammatory disease

Dr S. Lim-tio Prince Henry's Characterization of

928151 Institute of Medical mineralocorticoid

Research response elements

231

Name and Reg Key

Institution Title of Study

M edical Third-year renewals cant. Dr M. S. Lit win Institute of Medical & Regulation of the

928152 Veterinary Science adhesion of leukocytes

Dr H. G. Mack Howard Florey Institute of

to endothelium

Molecular study of

928154 Experimental Physiology pattern formation in the

& Medicine, eye

Dr T. P. Markovic Garvan Institute of The role of the liver and

928156 Medical Research lipid metabolism in the

Dr N. M avaddat University of Western

development of insulin resistance & NIDDM

Gamma delta T cell

928160 Australia heterogeneity and function

Dr C. R. Mayo Flinders University of Computer model of neuronal

928161 South Australia mechanisms underlying intestinal

Dr M. Mclean University of Newcastle

motor reflexes

Prediction of preterm

928162 labour by hormone

Dr S. G. McNamara Royal Prince Alfred

measurement in pregnancy

Upper airway reflexes in

928164 Hospital sleep apnea

Dr A. R. McNeil University of Melbourne Molecular events

928165 involved in cellular

Dr R. B. Oelrichs Ludwig Institute for

phospholipase A2 activation

Growth factors and growth

928169 Cancer Research factor receptors in

Dr S. L. Peake Queen Elizabeth

colonic epithelium

Anti neutrophil adhesion

928171 Hospital molecule antibodies in

Dr S. M. Proudman Royal Adelaide Hospital

ovine E.coli septic shock

Models for testing the

928176 arthritogenicity of T

Mr J. E. J. Rasko Walter & Eliza Hall

lymphocytes

Characterisation of

928179 Institute of Medical genes in the genesis of

Research myeloid leukaemia

232

>

Name and Institution Title of Study

Reg Key_________________________________________________________

M edical Third-year renewals cant. Dr A. C. Restifo Westmead Hospital Immunological profile of

928181 sensitised and high risk

renal transplant recipients

Dr M. A. Rosenthal Ludwig Institute for Myb proto-oncogene

928184 Cancer Research expression during colon

development and tumorigenesis

Dr J. Savulescu Monash University The concept of quality

928188 of life in medicine

Dr I. E. Scheffer University of Melbourne Genetic analysis of

928190 multiplex families with

epilepsy

Dr R. S. Schmidli Walter & Eliza Hall Improved techniques for

928191 Institute of Medical pre-clinical type 1

Research diabetes screening

Dr W. B. Smith Institute of Medical & Mechanisms and regulation

928196 Veterinary Science of neutrophil

transendothelial migration

Dr M. Stowasser University of Queensland Biochemical, morphological 928197 and genetic aspects of

prim ary aldosteronism

Dr S. 1. Strasser University of Melbourne Hormonal regulation of

928198 UDP-glucuronosyl

transferase in health & in liver disease

Dr A. M. Walker Prince Henry's Pathogenetic mechanisms

928203 Institute of Medical of glomerular and

Research interstitial scarring

Dr C. M. Ward Baker Medical Research Molecular determinants

928204 Institute of Von Willebrand Factor

dependent platelet adhesion

Dr C. P. White Garvan Institute of The role of osteocalcin

928206 Medical Research in bone cell biology

Dr G. M. Wood University of Queensland Adherence and

928209 immunomodulation

of branhamella catarrhalis

233

Name and Reg Key

Institution T itle o f S t u d y

D ental First Year Awards

Dr R.E. Mascord Institute of Dental Research The role of streptococcal 948007 proteins in the induction

autoantibody responses

Dr G.D. Walker University of Melbourne Localisation of trypsin-like 948009 protease from P Gingivalis

periodontitis

Second-year renewals Dr S.W.Y. Chan University of Melbourne Experimental oral

938001 mucosal carcinogenesis

and ascorbic acid deficiency

Dr A.M. Kilpi University of Melbourne The local inflammatory

938004 process in oral mucosal

lichen planus

Third-year renewals Dr A. Laslett University of Melbourne The oral health of young

928001 adults in rural Victoria

Dr Μ. I. Nataatmadja University of Melbourne Stem cells and tissue 928002 interactions in

odontogenesis and odontogenic cysts

Fourth-year renewals Miss J. Chandler University of Melbourne Influence of certain dental

918004 biomaterials on connective

tissue matrix in vitro

Mr J.A. Kaidonis University of Adelaide Human tooth wear:

918006 aetiological factors and

clinical significance

Dr R.Y.L. Zee University of Sydney Molecular genetic

918003 abnormalities in human

essential hypertension

234

Dora Lush SCHOLARSHIPS (Biomedical) Name and Reg Key Institution Title of Study

First Y ear A w a rd s Ms A.M. Beardsley Royal Adelaide Neuropeptide metabolites and

947412 Hospital and joint inflammation

Miss K.J. Blight Institute of Medical A study of the hepatic

947416 & Vetinary Science expression of hepatitis C virus

markers

Miss B Cancilla University of Melbourne The role of growth factors in

947423 kidney development

Mr R.J. Center St Vincent's Institute Structure and function of HIV

947425 of Medical Research and SIV envelope glycoproteins

Dr Y Chu Lions Eye Institute Cellular and molecular

947430 mechanisms which delay

photoreceptor dystrophy

Dr Z Chu University of Study of mechanisms of

947431 Western Australia pregnancy-induced

vasodilation in the rats

Dr W.P. Gai The Flinders Neuronal vulnerability in

947456 University of South

Australia

Parkinson's disease

Miss C.E. Gustafson University of Complementation of suppressor

947464 Queensland gene defects incolorectal cancer

cell lines

Miss S Houssami St Vincent's Synthesis and regulation of

947480 Institute of Medical the calcitonin receptor in

osteoclast development

Miss C.A. Jackson University of Melbourne Characterisation of methyl-947483 malonyl-CoA mutase in

Porphyromonas gingivalis

Ms N Konstantopolous University of Melbourne 947495

235

Structural requirements for insulin receptor tyrosine kinase activation

Name and Reg Keg

Institution Title of Study

First Year Awards cant. Mrs J.H. Leonard Queensland Institute Market cell carcinoma

947504 of Medical Research

Ms G.B. Luckensmeyer University of The role of the pelvic

947508 Queensland ganglia in the innervation

of the large intestine

Ms M.A. Ogierman University of A structural/functional

947518 Adelaide analysis of the haemolysin

of El Tor V.cholerae 01

Mr D.J. Pearce University of Collagen metabolism in

947528 Western Australia metabolic disease of bone

cartilage

Miss M.P.K. Sarna Western Australian The migration of tum our cells

947542 Research Institute

for Child Health Ltd

across endothelia

Ms K.J. Sweeney Garvan Institute of Regulation of cyclin function

947557 Medical Research in breast epithelial cells

Ms J.T. Tellam University of Role of synaptic vesicle

947559 Queensland proteins in insulin-regulated

Nr N.J. Whitaker University of The role of the retinoblast-

947572 Queensland oma gene in immortalisation

of human cells

Mr R.L. Young Austin Hospital Altered gene expression in

947582 cardiac hypertrophy

Second-year renewals Ms K.E. Anderson Baker Medical Research The phosphatidylinositol 937403 Institute turnover pathway in

myocardial ischaemia

Ms T.M. Bryan Children's Medical Immortalisation of human

937422 Research Foundation cells

Ms K. Cullen University of Sydney Comparative neuropathology

937437 of the human nucleus basilis

236

Name and Re% Key

Institution Title of Study

Second-year renewals cont. Mr P.J. Davies Monash University The involvement of the

937438 pelvic ganglia in the

urinogenital system

Mrs A. Fox University of MElboume Immunology of TCRt

937453 intraepithelial lympocytes

Ms J. Graham University of Sydney Identification of markers

937460 of progestin in human

breast cancer

Ms E.V.L. Grgacic Macfarlane Burnet Role of surface antigens

937461 Centre for Medical and N-Myristylation in

Research Hepatitis B virus replication

Ms D.L. Hailstones Children's Medical Regulation of nonmuscle

937483 Research Foundation isoforms of cytoskeletal

proteins during myogenesis

Ms A.G. H arpur Ludwig Institute for The structural and

937464 Cancer Research functional analysis of the

JAK family of protein kinases

Mr R.M. Hopkins Murdoch University Giardia from Aboriginal

937474 communities — genetic

diversity and DNA fingerprinting

Ms M.T. Lane Monash University Elevation and

937499 determination of mouse

embryo viability after culture in vitro

Miss J.A. Mckenzie Queensland Institute Cloning and function

937531 of Medical Research of a hum an melanoma antigen

Ms I. Moeller Royal Children's Molecular basis of

937513 Hospital, Victoria reduced collagen synthesis

in osteogenesis imperfecta type 1

Name and Institution Title of Study

Reg Key__________________________________________________________

Second-year renewals cent. Mr S.T. Moore Royal Prince Alfred An image processing system

937516 Hospital for real time binocular

3-d eye measurement

Miss M. Rakopoulos St Vincent's Institute Osteoclast activation and

937545 of Medical Research differentiation by

C-Terminal PTHrP peptide

Miss S.J. Ramus M urdoch Institute for Use of illegitimate

937547 Research into Birth transcripts to detect

Defects mutations causing genetic

diseases

Ms M.C. Ryan Austin Hospital Localisation and regulation

937554 of natriuretic peptide

systems in brain

Mr D.C. Tscharke Institute of Medical & Immune control of neural herpes

937578 Veterinary Science simples virus infection

Third-year renewals Mrs L.J. Bendall University of Sydney Cell adhesion molecule

927415 expression in malignant

haematological disorders

Ms J.A. Boothman U niversity of Melbourne In vitro and in vivo studies 927421 on the role of cytokines in

glomerular disease

Ms L.C. Daws Flinders University of Ontogeny of cholinergic

927435 South Australia hyperactivity in an animal

model of depression

Miss R.M. Kluck Queensland Institute of The biochemistry of

927486 Medical Research apoptosis — the role of

intracellular calcium and proteins

Miss L.A. Knodler University of New South Arginine metabolism in 927487 Wales parasitic protozoa

Miss K.L. Jenkins 927476 University of Technology Specific inhibitors of metalloproteinases

produced by rat carcinoma cell lines

238

Name and Reg Key

Institution Title of Study

Third-year renewals cant. Mr G.W. Lambert Baker Medical Research Biochemical indicators 927493 Institute of hum an CNS function

Mrs K.K. Lienert Queen Elizabeth Hospital Immunogenetic analysis of 927498 the HLA region in

Australian Aborigines

Dr C.B. Little University of Sydney The effects of abnormal

927499 mechanical loading on

the metabolism of cartilage proteoglycans

Ms H.E. Maclean Royal Children's Hospital The molecular mechanisms 927501 Research Foundation of abnorm al male sexual

differentiation

Mr D.A. Pan Royal Prince Alfred M embrane lipid effects

927513 Hospital on muscle insulin action

and metabolic rate

Miss S.J. Richardson University of Melbourne Studies of the 927527 evolution of the thyroid

horm one system

Mr D.I. Stapleton St Vincent's Institute Purification and

927549 of Medical Research regulation of the

AMP-activated protein kinase

Mr S.S.T. To Royal North Shore Endothelial activation

927560 Hospital molecules in rheumatoid

arthritis

Miss K. Traianedes St Vincent's Institute Effects on osteoblasts

927563 of Medical Research of components of the

bone extracellular matrix

Ms H.A. Vaughan Austin Research Institute The isolation and

927565 characterisation of cell

surface antigens

Ms V.J.C. Villiere University of New South Pharmacological 927567 Wales mechanism in neuronal

dependence

Ms ]. Zhan Monash University O dour processing: the

927581 role of newly-identified

membrane molecules

239

AUSTRALIAN AND OVERSEAS TRAINING FELLOWSHIPSC J MARTIN FELLOWSHIPS 1994 Name

Dr A. Yap

Dr R. Brink

Mr R. O'Shea

Ms K. Dora

Proposed Institute

For two years study at the Sloan-Kettering Institute for Cancer Research, New York and two years study at the University of Queensland

For two years study at the Whitehead Institute for Biomedical Research, USA and two years at the Centenary Institute of Cancer Medicine and Cell Biology

For two years study at the Scripps Research Institute, USA and two years at the University of Melbourne, Department of Medicine

For two years study at the University of Virginia, USA and two years at the University of Tasmania, Department of Biochemistry

P r o p o s e d s t u d y a n d

c o m m e n c in g s t i p e n d

Role of cadherins in cell-cell communication

Stipend: S36,285 plus airfares and allowances

Cellular signalling through the erythropoietin receptor

Stipend: 536,285 plus airfares and allowances

Neurological consequences of transgenic overexpression of nitric oxide synthase in brain

Stipend: $36,285 plus airfares and allowances

Alpha-adrenergic regulation of microvascular function

Stipend: 536,285 plus airfares and allowances

240

Namι Proposed Institute Proposed study and

commencing stipend

Dr B. Vissel For two years study at Effects of altered

the Salk Institute, USA calcium flux

and two years at the through mutated

Garvan Institute of glutamate receptors

Medical Research in transgenic mice

Stipend: $36,285 plus

airfares and allowances

Mr R. McKinnon For two years study at Hum an AH-receptor

the University of transgenic mice for

Cincinnati Medical risk assessment

Center, USA and two years at the Flinders Stipend: $36,285 plus

University of South airfares and allowances

Australia

Ms A. Verhagen For two years study at Role of the CD2

Deutsches extracellular domain

Krebsforschungszentrum in signal transduction Angewandte Immunologie, Germany and two years Stipend: $36,285 plus

at the Walter and Eliza airfares and allowances

Flail Institute for Medical Research

Mr T. Cox For two years study at Cloning and

the Institute for characterisation of

Molecular Genetics the gene(s) for

Baylor College of microphthalmia with

Medicine, USA and two linear skin defects

years at Adelaide (MLS) syndrome

Women's and Children's Hospital Stipend: $36,285 plus

airfares and allowances

Mr R. Johnstone For two years study at Mechanism of

Harvard Medical School, transcriptional

USA and two years at repression mediated

the Austin Research by YY1

Institute

Stipend: $36,285 plus

airfares and allowances

241

Name Proposed Institute Proposed study and

commencing stipend

Dr C. Sobey

Dr W. Greene

Mr J. Hunt

Dr W. Smith

For two years study at the College of Medicine, University of Iowa,

USA and two years at the University of Melbourne

For two years study at the MRC Laboratory of Molecular Biology, UK and two years at the Princess Margaret Hospital for Children

For two years study at Harvard Medical School, USA and two years at the University of NSW

For two years study at the Wright-Fleming Institute, London, and two years at the

Institute of Medical and Veterinary Science

Effect of sympathetic nerves on cerebral vascular tone in vivo: importance of endothelium

Stipend: $36,285 plus airfares and allowances

Human acute T-cell leukaemia: role of the rhombotin (Ttg) gene family

Stipend: $36,285 plus airfares and allowances

Regulation of transcription of the mouse mast cell protease gene, mMCPl

Stipend: $36,285 plus airfares and allowances

Allergic inflammation in asthma

Stipend: $36,285 plus airfares and allowances

242

NEIL HAM ILTON FAIRLEY FELLOWSHIPS 1 9 9 4 Name Proposed Institute Proposed study and

commencing stipend

Dr N. Della For two years study at Isolation of RPE-

the Wilmer specific genes and

Ophthalmological evaluation of their

Institute, John Hopkins possible role in

University, USA and two retinal disease

years at the Flinders Medical Centre Stipend: $36,285 plus

airfares and allowances

Mr J. Mattingley For two years study at Assessment and

the University of rehabilitation of

Cambridge, UK and two attentional and

years at Monash University motor deficits in unilateral neglect

Stipend: $36,285 plus airfares and allowances

Dr D. Piper For two years study at Microvascular injury

Victoria Hospital in sepsis

Research Institute, Canada and two years at Stipend: $36,285 plus

the Royal North Shore Hospital airfares andallowances

Dr F. Cicuttini For two years study at A twin study of

St Thomas' Hospital, osteoarthritis

UK and two years at the Royal Melbourne Hospital Stipend: $36,285 plus airfares and allowances

Dr D.L. Duffy For two years study at Yale Genetic epidemiology asthma

University USA, and two years at milignant melanoma

Queensland Institute of Medical Research Stipend: $36,285 plus

airfaires and allownces

Dr C. Fairley For two years study at Experience in

PHLS Communicable infectious disease

Diseases Serveillance epidemiology

Centre, UK and two years at the Monash University Stipend: $36,285 plus airfares and allow ances

243

AUSTRALIAN POST-DOCTORAL FELLOWSHIPS 1994 Name

Mr M. Hulett

Proposed Institute

For four years study at the Austin Research Institute

Proposed study and commencing stipend A novel natural killer cell gene: characterization and transcriptional control

Ms J. Bowles

Dr T. Johns

Miss V. Avery

Dr J. Whitley

For four years study at the Centre for Molecular Biology and Biotechnology, University of Queensland

For four years study at the Monash Medical Centre

For four years study at the University of Adelaide

For four years study at the Austin Hospital

Stipend: $36,285 plus maintenance

Molecular genetics of human sexual development: transgenic mouse models

Stipend: $36,285 plus maintenance

Characterization of proteins associated with myelination

Stipend: $36,285 plus maintenance

Molecular and cellular studies of the type II IGF receptor

Stipend: $36,285 plus maintenance

The role of gastrin-releasing peptide during pregnancy and foetal development

Stipend: $36,285 plus maintenance

Dr I. Matsumoto For four years study at The Alcohol Research Unit, University of Queensland

Molecular neurobiology of ethanol withdrawal and ethanol-induced brain damage

Stipend: $36,285 plus maintenance

244

FELLOWSHIPS FOR RESEARCH IN DEMENTIA AND DEMENTIA CARE 1994 Name Proposed Institute Proposed study and

commencing stipend

Mr M. Bird For four years study Psycho-social

at the Social interventions for

Psychiatry Research behavioural problems

Unit, Australian in senile dementia

National University

Stipend: $36,285 plus maintenance

Dr E. Storey For four years study Alzheimer's disease:

at Melbourne University APP function and beta

A4 toxicity in hippocampal and cortical cultures

Stipend: $36,285 plus maintenance

SOROPTIMIST POSTDOCTORAL FELLOWSHIP IN DEMENTIA RESEARCH 1994

Name Proposed Institute Proposed study and

commencing stipend

Dr D. Lo Giudice For four years study The utility of a

at the Northwest memory clinic in

Hospital reducing carer stress

Stipend: $36,285 plus maintenance

245

RESEARCH FELLOWSHIPS APPOINTMENTS PROMOTIONS AND RE-APPOINTMENTS 1994 Name and K LU KLY Institution Level of Appointm ent

In itia l A ppointm ents Dr E M Anders 940742 University of Melbourne Research Fellow Level 3

Dr G S Baldwin Ludwig Institute for Senior Research Fellow Level 1

940924 Cancer Research

Dr P J Blarney 930068

University of Melbourne Senior Research Fellow Level 5

Dr T Chan-Ling 940011

University of Sydney Research Fellow Level 1

Dr P J Fuller Prince Henry's Institute Senior Research Fellow Level 4

930686 of Medical Research

Dr N K Hayward Queensland Institute of Research Fellow Level 2

941136 Medical Research

Dr R 1 McLachlan Prince Henry's Institute Senior Research Fellow Level 1

943208 of Medical Research

Dr A J Mackinnon Australian National Research Fellow Level 3

933301 University

Dr P Molenaar 940159

University of Melbourne Research Fellow Level 1

Dr R Rajan 941006

Monash University Research Fellow Level 1

Dr R G Ramsay Ludwig Institute for Research Fellow Level 1

940936 Cancer Research

Prof M S Roberts 941155

University of Queensland Senior Principal Research Fellow

Dr L A Salamonsen Prince Henry's Institute Research Fellow Level 2

940538 for Cancer Medicine

Dr Μ B Singh 940091

University of Melbourne Senior Research Fellow Level 2

246

Name and KEGKEY Institution Level of Appointment

D rP D Sly University of Western Senior Research Fellow Level 6

941252 Australia

Dr R Stocker Heart Research Institute Senior Research Fellow Level 4

940915

Prom otions A /Prof J L Black 1

University of Sydney Principal Research Fellow Level

940051

Dr P L Ey University of Adelaide Senior Research Fellow Level 2

940324

Dr J E Gready University of Sydney Principal Research Fellow

940616 Level 1

Dr P H Hart Flinders University of Senior Research Fellow

940189 South Australia Level 1

Dr P I Mackenzie Flinders University of Principal Research Fellow

910303 South Australia Level 1

Dr H Majewski Prince Henry's Institute Principal Research fellow

940995 of Medical Research Level 1

Dr M M urray University of Sydney Principal Research Fellow

910592 Level 1

Dr P G Tipping Monash University Senior Research Fellow

940389 Level 1

R eappointm ents

Dr B A Baldo University of Sydney Principal Research Fellow

940036 Level 4

Dr P J Berger Monash University Senior Research Fellow

940487 Level 3

Dr R F Bishop Royal Children's Hospital Senior Principal Research

940302 Research Foundation Fellow

247

Name and KEGKEY Institution Level of Appointment

Dr W W Blessing Flinders University of Principal Research fellow

940102 South Australia Level 4

A /Prof IJ Clarke Prince Henry's Institute Principal Research Fellow

940994 of Medical Research Level 4

Dr T M Cocks University of Melbourne Senior Research Fellow

940157 Level 3

Dr B S Coulson Royal Children's Hospital Research Fellow Level 3

940315 Research Foundation

Dr R G Dickinson University of Queensland Principal Research Fellow

941083 Level 4

Dr S A Dunlop University of Western Research Fellow Level 3

940693 Australia

Dr A M Gero University of New South Senior Research Fellow

940589 Wales Level 6

Dr J E Gregory Monash University Senior Research Fellow

940593 Level 3

Dr M D Grounds University of Western Senior Research Fellow

941266 Australia Level 4

Prof P Holt University of Western Senior Principal Research

940694 Australia Fellow

Dr D C Jackson University of Melbourne Principal Research Fellow

940158 Level 4

Dr A J McLean University of Adelaide Principal Research Fellow

943301 Road Accident Research Unit Level 4

Dr C D Scott Royal Prince Alfred Research Fellow Level 3

940472 Hospital

Dr W Thomas University of Western Principal Research Fellow

941259 Australia Level 2

Dr K S Turker University of Adelaide Research Fellow Level 3

940829

248

APPENDIX VI — A su m m a ry of Public H ealth R esearch a n d D evelopm ent g ra n ts fo r 1994

New Awards STATE Projects Small grants Development prgram

grants

Fellowships

NSW 7 350,383 3 55,260 1 184,115 1 52,845

VIC 7 334,722 4 75,440 1 206,645 9 437,725

QLD 6 284,630 1 20,000

SA 5 207,249 1 19,747

WA 3 144,986 1 45,269

TAS 1 9,175 1 52,845

ACT 2 18,113

NT 1 65,889

Sub Total 1,387,859 197,735 390,760 588,684

Scholarships

3 66,235

4 86,414

1 23,028

2 40358

1 23,028

1 23,028 262,091

Continuing Awards STATE Projects Development Aboriginal Fellowships Post training Scholarships Other Cont.

______________________ program grants research grants_________________ fellowships____________________________

NSW 7 328,051 2 490,033

VIC 7 329,189 1 184,495

QLD 1 250,656

SA 2 39,696

WA 4 266,252

TAS

ACT .

NT 4 198,053

Sub Totals 1,161,241 925,184

4 176,714

2 248,256 2 98,181

1 34346

3 87,536

1 76,564 1 57,243

1 54,890

1 41,578 366,398 417321 91,589

5 91,459

2 28,073

4 74,900

1 20,179

3 63386

1 40,000

1 20,179

298,176 373,571

N E W PROJECT G RA N TS 1 9 9 4

Name, Institution and REGKEY Title of study Amount of sup

$

Dr M.J. Abramson Asthma M anagement and Mortality

Monash University from Asthma 65,526

944033

Dr R.J. Bell A randomised trial of reduced

Royal Women's Hospital, Vic antenatal exerciseto increase 944009 birthweight 29,616

Dr J.A. Bowman Alcohol intervention by Community

Hunter Area Health Service Counsellors: A randomised clinical 944065 trial 50,246

Professor G.A. Broe Predictors of successful and

University of Sydney unsuccessful ageing in relation to

944038 service use 64,415

Professor P.M. Brooks Cost and Cost Effectiveness of

University of NSW treatment of Rheumatoid and

944099 Osteoarthritis 51,163

Dr R.A. Cummins An evaluation of life-quality for

Deakin University people with intellectual

944107 disabilities 66,653

A /P rof L. Dennerstein The Melbourne Women's Midlife University of Melbourne Health Project 36,069

944006

Dr R.A. Gibson A critical examination of formulas in

Flinders University of SA the nutrition of term infants 48,829

944143

Dr S.M. Gifford Perceptions of risk for STDs among

La Trobe University women from non-English speaking

944125 backgrounds 55,022

Dr P.A. Hamdorf The fitness and habitual activity

Royal Adelaide Hospital patterns of 80-90 year old females: 944042 effects of a 6 month training program

and subsequent follow-up 22,343

250

N ew Project G ran ts cont. Name, Institution and REGKEY Title of study Amount of support

$

Dr J.N. Hanna An evaluation of the Aboriginal

Peninsula and Torres Strait infant Hepatitis B Immunisation Regional Health A uthority programme 43,146

944052

Professor B.A. Hayes Perinatal Dysphoria: recognition

James Cook University of and management at three sites in North Queensland Australia 46,294

944134

Dr J.L. H opper A prospective twin study of risk

University of Melbourne behaviours from adolescence to 944028 adulthood 33,524

Dr K. Jamrozik Follow up cases and controls in the

University of WA Perth Community Stroke study 20,372

944083

Dr N.H. de Klerk Environmental exposure to asbestos

University of WA and malignant disease 62,509

944051

A /Prof J.B. Lowe Evaluating a Secondary School

University of Queensland Program to Increase Sun-Protective 944112 Behaviour 58,493

Dr J.M. Lumley Postnatal and infancy study of

Monash University Vietnamese, Turkish and Filipina

944128 Women 48,312

Mr D.B. McPherson Effectiveness of New Technology in

University of Queensland community based infant hearing 944138 screening 38,091

Dr P.J. Phillips Diabetes Care in general practice —

Queen Elizabeth Hospital, SA risk factors, complications and 944058 quality of life 59,175

Ms J.E. Ritchie The Health Promoting Worksetting 40,560

University of NSW 944098

251

N ew Project G ran ts cont. Name, Institution and REGKEY Title of study

Dr M. Sawyer Women's and Children's Hospital, SA 944135

A Prospective Study of the Psychosocial Sequelae of childhood cancer

Amount of support $

18,864

Dr S.M. Sayers Menzies School of Health Research 944053

Risk factors and outcome of Aboriginal infants born at Royal Darwin Hospital 65,889

Dr M.C. Sheehan The Health and Well being of

University of Queensland Hairdressers 60,515

944115

A /P rof L.A. Simons University of NSW 944067

Prospective study of Heart and other diseases in the elderly: Dubbo Study

Dr B.J .Smith Queen Elizabeth Hospital SA 944119

Prevalence of Asthma, smoking and high risks (N 02 Producing) Household appliances in the Le-Fevre Peninsula Region, SA

43,018

58,038

Dr V. Smyth University of Queensland 944114

Prof F.J. Stanley University of WA 944081

Mr R.A. Walsh H unter Area Health Service 944072

DrJ.E. Ward University of NSW 944068

The use of new Otoacoustic emission technology for testing hearing in neonates

The Aetiology and Prevention of Cerebral Palsy

Trial of Dissemination strategies for antenatal smoking cessation programs

Evaluation of Doctors' reminders in casualty to encourage Pap smears

38,091

62,105

63,388

37,593

252

C O N T IN U IN G PROJECT GRANTS Dr R F Bishop Rotavirus serotypes causing

Royal Children's Hospital (VIC) epidemics of diarrhoea in 932037 Australian children 52,197

Dr J B Carlin Case-control study of child

Royal Children's Hospital bicycle injuries/risks, exposure 932029 and education 43,432

Mr A A Catanese Efficacy of conductive

Royal Children's Hospital (VIC) education for children with motor 932028 disorders 47,195

Mr M Davies Effect of reduced w ater fluoridation

University of Adelaide 922050

on dental caries in children

17,039

Prof C E Ewan Com m unity perceptions of

University of Wollongong environmental health risk — lead 932101 as a case study 66,913

Ms J Hall Cost-utility analysis of the

Westmead Hospital treatm ent of early stage breast

932001 cancer 59,830

Dr JH anna Post-licensure evaluation of

University of WA haemophilus influenzae vaccines in

922051 Australia 87,933

Dr B Jalaludin Ambient air pollution and asthma

Western Sydney Area Health Service morbidity in Western Sydney 48,052

932084

Dr D Jenner Evaluation of school nutrition and

University of WA 922053

physical activity programs

44,262

Dr M W Knuiman Familial aggregation and regression

University of WA 932089

dilution of CVD risk factors

53,507

Dr H Kuhse Ethical issues in resource allocation

Monash University 932031

on the basis of Quality of Life

60,638

253

C O N T IN U IN G PROJECT G RA N TS c o n i

Name, Institution and REGKEY Title of study Amount of support

$

Ms A Lee Evaluation and improvement of

Menzies School of Health nutrition intervention strategies in Research (NT) aboriginal communities 59,020

922042

Ms F Lovejoy Health Care and prevention

University of NSW practices among private female

932124 prostitutes in New South Wales 39,658

Prof J D Mathews Strategies for communicable disease

Menzies School of Health control in Aboriginal Australians Research (NT) 66,355

932120

Prof A McMichael The long-term effects of exposure to

University of Adelaide environmental lead in childhood —

932054 extended follow-up of Port Pirie cohort 22,657

Prof J J McNeil The efficacy of oral beta-carotene for

Monash University human papillomavirus infection

932097 50,012

Dr M Mira The prevalence of serological

Royal Prince Alfred Hospital evidence of immunity to measles, (NSW) mumps and rubella in two to five year

932079 old children 35,304

Dr C Mountford Assessment of human biopsy

University of Sydney specimens by magnetic resonance

922074 spectroscopy 69,607

Prof K O'Dea Interventions to produce sustained

Deakin University weight loss in overweight

93209 Aborigines 52,610

Dr A Read Respiratory illness in early

University of WA childhood: social and biological

922063 determinants 80,550

254

C O N T IN U IN G PROJECT GRANTS c o n t.

Name, Institution and REGKEY Title of study Amount of support

$

Dr D J Scrimgeour Menzies School of Health Research (NT) 932022

Evaluation of diabetes control activities in Central Australia

33,738

Dr S A Thomas La Trobe University 932033

The rehabilitation of older injured workers 23,105

NEW SMALL GRANTS 1994 Name, Institution and REGKEY Title of study Amount of support

$

Prof G Vimpani Hunter Area Child and Family Health Service (NSW) 922033

Greater Newcastle asthma in schools prevention project (GASP)

8,687

Dr M.A. Bermingham University of Sydney 944803

Risk factors for Coronary Heart Disease and diabetes in Aboriginal women 20,000

Dr L.F. Brown University of Melbourne 944805

Measuring the impact of differing forms of periodontal diseases 16,018

Mr D.A. Crawford Australian National University 944810

Body weight and its control in Adults

8,902

Dr L.M. Day Monash University 944811

Epidemiology of injury to adults 25-65 years of age 20,000

Professor G. Geffen University of Queensland 944817

Evaluation of early measures of severity of closed head injury 20,000

Dr A.L. Herczeg CSIRO, Division of Water Radon and Radium in drinking water: Is there a health risk? 19,747

Resources

NEW SMALL GRANTS 1 9 9 4 cont, Name, Institution and REGKEY Title of study Amount of support

$

Mr J.W. Langford Understanding and preventing

University of Tasmania injuries in a rural community

944826 9,175

Dr M.N.D. Lassere Predictors of carer stress in arthritis 15,743

St George Hospital, NSW 944827

Mr J.M. Lewis Dental Services Evaluation 19,509

University of Melbourne 944828

Dr J.W. Meehan Visual detection of Melanoma 19,913

Anti-Cancer Council of Victoria 944834

Mr Z. Steel Mental Health Service Needs of On-

University of NSW Shore Asylum seekers

944855 19,517

Dr J.F. Thompson Premature Infants: Mother's

Australian National University Experiences and Parenting Stress 944856 9,211

NEW DEVELOPMENT PROGRAM GRANTS Professor]. McNeil Prevention of Cataract in the elderly

Monash University with low-dose aspirin and Vitamin E

944610 206,645

Dr B. Oldenburg Behavioural and structural

University of Sydney interventions for workplace health

944605 promotion 184,115

256

CONTINUING DEVELOPMENT PROGRAM GRANTS Dr A Green Queensland Institute of Medical Research 922608

Trial of sunscreen and beta carotene in the prevention of skin cancer, photoageing and cataract 250,656

Prof R Sanson-Fisher University of Newcastle 922602

Community development in rural communities 267,652

Prof R Heller University of Newcastle 902657 D rJW ark

University of Melbourne 902667

Prevention of coronary heart disease 222,381

Dietary interventions & bone mass: studies in twins 184,495

OTHER CONTINUING GRANTS Consumers' Health Forum On-going annual contribution 40,000

NHMRC Research Unit in Health 1994 payment of five year Program Evaluation commitment to fund this Unit 333,571

CONTINUING ABORIGINAL HEALTH RESEARCH PROJECT GRANTS Name, Institution and REGKEY Title of study

Dr J.H. McKendrick Rumbalara Aboriginal Cooperative Ltd 944503

Assessment of mental health and service needs in an Aboriginal community

Amount of support $

159,515

Professor K. O'Dea Deakin University 944502

Susceptibility of Australian Aborigines to obesity and diabetes 88,741

Professor P. Prociv Galiwinku Com m unity Council 944505

Professor F.J. Stanley Western Australia Research Institute for Child Health

944504

Anaemia and hookworm infection - the benefits of a treatment programme

'Mooditj Mums' — a program of enhanced antenatal and postnatal care

41,578

76,564

257

NEW FELLOWSHIPS 1994 Name, Institution and REGKEY Title of study Amount of support

$

Dr L.M. Alessandri Studies in perinatal, infant and childhood

Western Australian Research mortality Institute for Child Health 45,269

944218

Dr F. Cicuttini Safety and efficacy of chronic

Monash University acetaminophen use in individuals

944221 aged >65 years for the treatment of 52,845

osteoarthritis

Dr M. Crotty Musculoskeletal disability and

University of NSW occupational therapy — a controlled trial

944222 52,845

Dr L.M. Day Epidemiology of rural injury in Victoria

Monash University and the potential for prevention

944302 45,269

Mr J.R.W. Fisher Obstetric intervention: A Once and Future

University of Melbourne Thing? Psychological aspects of Obstetric 944224 Intervention in Multiparous women 45,269

Dr J.L. Fitzgerald Contextualising illegal drug use: Instituting

University of Melbourne 944225 Use in hidden population 45,269

Mr M. A. Jenkins A Study of Asthma in Pedigrees of three

University of Melbourne generations sampled from a population 944308 survey 45,269

Dr A.L. Ponsonby Sudden Infant Death Syndrome and

University of Tasmania asthma — a prospective cohort study 944215 52,845

Dr J. Savulescu Good reasons to die

Monash University 944203 52,845

Ms J.M. Smith Integrated field, clinical and molecular

MacFarlane Burnet Centre studies on Hepatitis C virus infection in for Medical Research injecting drug users

944226 45,269

258

Name, Institution and REGKEY Title of study Amount of support

$

NEW FELLOWSHIPS 1994 cont. Dr J.A. Thomson Prevention of Cataract in the elderly

Monash University 944204

with low dose aspirin and Vitamin E 52,845

Dr A.J. Venn Monash University 944304

Health and Pregnancy outcomes after assisted conception 52,845

CONTINUING FELLOWSHIP AWARDS 1994 Ms C Bookless-Pratz Flinders University of SA 919216

The effect of appraisal on psychiatric patient social functioning 39,184

Dr C K Fairley Monash University 919206

Role of human papillomavirus in cervical cancer 58,997

Dr M D Gliksman University of Sydney 919224

Preventable risk factors for stroke in the elderly 58,997

Dr P R Lewis University of Newcastle 932213

Validation of comprehensive surveillance system for asthma 54,911

Dr T S W eeramanthri Menzies School Health Research 929221

Preventable factors in adult Aboriginal deaths in the Northern Territory 54,890

Dr D P Weller University of Adelaide 909226

Evaluation of bowel cancer screening project in primary care 27,432

Ms E J Wright University of Melbourne 919222

Australian changing food industry — a regulatory scheme for the future 39,184

259

Name, Institution and REGKEY Title of study Amount of support

$

CONTINUING POST TRAINING FELLOWSHIP 1994 Dr J Pick Curtin University of Technology 932305

The analysis of spontaneous motor rhythms in infants as a means of early detection of cerebral palsy. 57,243

Dr K L Radimer University of Queensland 929301

Implication of dietary guidelines for Women's health 34,346

NEW SCHOLARSHIPS 1994 Mr O.A. Abdulwadud Monash University 944970

Evaluation of asthma management strategies in the hospital and community 20,179

Dr N. Badawi Western Australian Research Institute for Child Health 944973

Antecedents and outcome of newborn encephalopathy in term infants 23,028

Dr J.R. Carapetis Mcnzies School of Health Research 944958

Streptococcal surveillance and disease prevention in Aboriginal Australians 23,028

Miss C.L. Chock University of Sydney 944962

Optimal designs for comparing screening tests 20,179

Dr S.M. Crockett La Trobe University 944966

An ethnographic study of sexual health issues among Vietnamese and Turkish bom women living in Melbourne 23,028

Dr W.A. Fisher Monash University 944946

The effects of prophylactic treatment with Vitamin E on the progression of Carotid Atheroma 23,028

Ms j.M. Lewis University of Melbourn 944310 Public Health Policy and evaluation 20,179

260

Name, Institution and REGKEY Title of study

NEW SCHOLARSHIPS 1994 cont.

Amount of support $

Ms V.M. Moore University of A delaide 944938

The antenatal origins of chronic disease: an investigation of new opportunities for prevention 20,179

Ms J.M. M udge University of Adelaide 944940

The long term effects of lead exposure on the psychosocial development of children 20,179

Mr L. Straker University of Sydney 944303

A psychosocial, physiological and biomechanical comparison of single and combined manual handling tasks 23,028

Dr B.A. Walsh Syncope in the elderly: A community

University of Newcastle based prevalence and clinical study 23,028

944905

Dr D.C. W hiteman Risk factors for Site-specific

Queensland Institute of melanoma in older men

Medical Research 944906

23,028

CONTINUING SCHOLARSHIPS 1994 Dr S A Aldridge Evaluation of new infant hearing

Royal Children's Hospital (VIC) screening program in the state of Victoria 23,028 929100

Ms J M Barratt Improved quality of home care services

University of Western Australia for people with continuing disabilities 23,028 929102

Ms H A Burchmore Australian mental health service systems:

University of N ew South Wales Structure, function, organisation and 929110 effectiveness 20,179

Mr C B Burns Social and medical predictors of

Menzies School of Health Research remission, mortality and morbidity 932111 in petrol sniffers with emphasis on

positive outcomes 20,179

261

Name, Institution and REGKEY Title of study Amount of support

__________________________________ $

CONTINUING SCHOLARSHIPS 1994 coni. Mr M Dobson University of Sydney 919119

Evaluation of psychiatric treatment services for victims of traumatic stress 20,179

Dr D L Duffy Asthma and allergy in Australian twins

Queensland Institute of Medical and their families Research 11,514

919105

Dr P Dugdale University of Sydney 932204

Relating health objectives, data service patterns in health policy development 23,028

Mr J Grossman University of Sydney 932119

Ms J L Halliday Murdoch Institute Victoria 929110

Ms L J Lambert University of Western Australia 932129

Sampling properties of some simple Bayesian m ethods for meta-analysis and other hierarchial problems in epidemiology 23,028

Utilisation of amniocentesis and chorion villous sam pling in Victoria and subsequent perinatal outcome 5,045

Hysterectomy, Hormones and acute myocardial infarction: A case control study 20,179

Ms D M Lloyd An intervention to reduce the burden of

University of Newcastle illness due to post natal depression 5,045

929114

Dr W J McBride James Cook University 932134

Mr L J Palmer University of Western Australia 932141

Ms J H Patterson University of Adelaide 932142

Ms K M Thurecht University of Queensland' 932149

Mr P C Veitch University of Queensland 932150

Health impact of aboviral infections in North Queensland 23,028

The role of antenatal and postnatal maternal smoking in modulating genetic atopic potential 20,179

Complaints system as a mechanism for consumer participation in health care setting 20,179

Social context surrounding pap smear screening for cervical cancer 20,179

Factors influencing rural consumers health care decisions

262

20,179

APPENDIX VII — List of publications issued b y Council 1993 Epidural use of steroids in the management of back pain and sciatica of spinal origin

Standard for the uniform scheduling of drugs and poisons No. 7 + am endm ents 1, 2,3 &4

MRL Standard: Standard for maximum residues of pesticides, agricultural chemicals, feed additives, veterinary medicines and noxious substances in food and anim al feedstuffs

National im m unisation strategy

Nationally notifiable diseases and surveillance case definitions

General guidelines of providing information to patients

Screening for the prevention of cervical cancer — guidelines for the m anagement of wom en with screen detected abnormalities

Life-sustaining home ventilation for children and young adults

Mental disorders in the older person — recognition and management

Report on m aternal deaths in Australia 1988-90

Treatment of obstructive sleep apnea

Exercise and the older person

Case study of screening blood donations for hum an T-Cell lymphotropic virus Type 1 (HLTV-1)

Ethical considerations relating to health care resource allocation decisions

Musculoskeletal disorders in the older person

Incontinence and the older person

Falls and the older person

Perinatal m orbidity

Diabetes and exercise

Oral health care for older adults

Minimising adverse consequences of hospitalisation in the older person

Report on conductive education and its applicability in Australia

Towards elimination of tuberculosis

Malaria prophylaxis

National fram ework for environm ental and health impact assessment

Staying healthy in child care

263

APPENDIX VIII— M edia re le a s e s issu e d b y Council 1993 Medical research scholarship to honour wom en scientists World laboratory animal week: NHMRC calls expert meeting Bronchodilators not to be rescheduled New guidelines for notifiable diseases National imm unisation strategy called for to protect our children Setting indoor air quality levels Action on lead levels Parents cautioned on treatm ent for children with cerebral palsy Folic acid — protecting unborn children against spina bifida New guidelines set out patients' role in decision-making

Children on home ventilators — small num ber, large issues Your pap smear result is normal!!! W hen should action be taken?? NHMRC sets national standards for screening and m onitoring of child health Mental health care for the e ld e rly ....complex issue Eye treatment

Exercise and the elderly — use it or lose it!!! Preserving the health of Australia's expectant mothers Restrictions called for on skin care products NHMRC calls for more attention to w om en's health Screening and m onitoring of child health under review National health body w arns on hazards of boxing National framework to control tuberculosis Travellers advised to protect against m alaria Child care services helped to control infectious diseases Parents urged to im m unise children against whooping cough Target date set for reduced lead levels in Australia Plain English guide to hum an gene therapy Hospitals urged to update care of elderly patients Dental health changing in Australia National guidelines for clinical practice NHMRC moves to reduce perinatal m orbidity

Diabetics advised to plan exercise carefully Community views sought on organ donation, and on care in childbirth Brain tum or treatm ent — early stages, positive results Brain maps key to treatm ent of Parkinson's disease New research paves the way for better treatm ent of asthma Too much too little calcium bad for the body

264

APPENDIX IX— A nnual re p o rt of the NHMRC Com m issioner of Com plaints In accordance w ith Section 68 of the National Health and Medical Research Act Ί992 no applications were received.

Contact: Phone FAX:

9 - March 1994

Dr Diana Horvath Chairperson National Health and Medical Research Council Box 9848 CANBERRA ACT 2601

Dear Dr Horvath

Annual Report of Commissioner of Complaints

I am writing, in accordance with Section 68 of the National Health and Medical Research Council Act 1992, to report to the Council that during the period 24 June 1993 to 31 December 1993 no applications for me to investigate a complaint were received.

Yours sincerely

P G Livingstone AO Commissioner of Complaints

265

APPENDIX X— Inquiries b y P a r lia m e n ta r y Committees

There were no inquiries of Parliamentary Committees which were concluded during 1993 which examined any aspect of the operation of the National Health and Medical Research Council or were of significant relevance to the operation of the Council.

The NHMRC did not contribute a submission to any inquiry of a Parliamentary Committee during 1993.

2 6 0

A com plaint w as received by the Ombudsman concerning the actions of the NHMRC w ith regards to the report 'Conductive education and its applicability in Australia'. The com plaint related to the processes followed in the preparation of the report and the complainant asked that the report be withheld from the public.

The O m budsm an concluded that there had not been substantial defective adm inistration and that the complainant was not justified in seeking the w ithholding of the publication of the document as it now stands.

There were no recom m endations from the Ombudsman that am ounts be paid as Act of Grace paym ents following an investigation of a complaint.

APPENDIX XI — Comments by the O m budsm an

267

There were no judicial decisions or decisions of administrative tribunals handed dow n during the year which significantly affected the operation of the National Health and Medical Research Council.

APPENDIX XII — Decisions of Courts a n d A dm inistrative Tribunals

2 6 8

A description of the NHMRC and its functions required under Section 8 of the Freedom of Inform ation Act can be found elsewhere in this report. Details of the docum ents held by the NHMRC are covered by the description of docum ents held by the D epartm ent of H um an Services and Health and published in its Annual Report. Therefore this statem ent is restricted to access information and a

sum m ary of requests under the FOI Act 1982 during 1993.

A request under the Freedom of Information Act for access to NHMRC documents should be m ade in writing to:

The Executive Secretary National H ealth and Medical Research Council GPO Box 9848 Canberra City

ACT 2601

Telephone: (06) 289 7019

Facsimile: (06) 289 7802

There were three requests under the Freedom of Information Act 1982 during 1993.

One of those requests was completed within the timeframe allowed and a waiver was m ade on the paym ent of fees.

The second request was m ade in August 1993. As the initial request was very broad in scope (referring to all documents and records of information in possession by the NHMRC since its establishment), it was redefined in order for it to be able to be processed. Consultation on a num ber of documents took place and

this extended the timeframe of the request. The request was finally completed on 28 February 1994. The total of fees paid in relation to the request was $487.55.

The third request was received in December 1993 and had not been completed by the end of the period of this report.

APPENDIX XIII — Freedom of Information

269

No reports have been served on the NHMRC by the Privacy Commissioner under Section 30 of the Privacy Act 1988 during 1993.

No determ inations have been served on the NHMRC by the Privacy Commissioner under Section 57 of the Act during 1993.

No public interest determinations, in relation to the act or practice of the departm ent, have been m ade by the Privacy Commissioner under Section 72 of the Act during 1993.

APPENDIX XIV — Privacy

270

APPENDIX XV — E n v iro n m e n ta l a n d E nergy Issu e s

Lead

The dom inant activity during the year has related to lead, culm inating in the adoption of new lead in blood guidelines by the National Health and Medical Research Council (NHMRC).

At its June 1993 meeting, the NHMRC adopted a goal for all Australians of less than 10 m icrograms per decilitre of lead in blood, with particular urgency in achieving this for children aged 1 to 4 years.

This w as seen as considerably more stringent than the previous 'level of concern' of 25 m icrograms per decilitre set in 1987.

Along with the goal, a set of graduated responses was recommended for individuals and communities at a range of blood lead levels.

Exposure to lead is particularly detrim ental to young children whose intellectual developm ent can be impaired as a result of sustained exposure. Its main sources are petrol, paint and industry.

At its Novem ber 1993 meeting, the NHMRC recommended that the first target in achieving the goal should be a reduction of lead in all Australians to less than 15 micrograms per decilitre by 1998, w ith the exception of those occupationally exposed. NHMRC also recom mended that strategies in place to achieve the first

target should be such that 90% of children aged between 1 and 4 years will have blood lead levels below 10 micrograms per decilitre by the end of 1998.

In 1994, a national survey of children's blood lead levels will be initiated in co­ operation with State and Territory health agencies. M onash University has developed a m ethodology to guide the survey.

H e a lth a n d E n v iro n m e n ta l Policy

The Public Health Committee of the National Health and Medical Research Council, on the advice of its Environmental Health Standing Committee, is responsible for addressing environm ental issues which affect public health. This is undertaken by setting appropriate guidelines or developing recommendations that

the States and Territories can implem ent.

Current activity falls within four main areas: air, water and land quality and waste management.

Air Q u a lity

Guideline revisions are presently being undertaken for ambient and indoor air goals for nitrogen dioxide, form aldehyde, sulphur dioxide, ozone, and particulate matter.

271

W a t e r Q u a lity

Water quality issues include the revision of the drinking water guidelines, guidelines for use of reclaimed water, control of Legionella infections, health effects of toxic blue-green algae and rural and remote centre water supplies.

Land Q u a lity

A national workshop on contaminated sites was held for governm ent agencies in April 1993 to facilitate information exchange between agencies, and to develop a national strategy to further augment the National Guidelines for the Management of Contaminated Sites. National funding was provided for research projects to address issues related particularly to Australian conditions e.g. uptake of soil contaminants by home-grown produce. National research priorities have been agreed. These include the development of Australian models for risk assessment and evaluating community concerns about the significance of contaminated sites.

W a s te M a n a g e m e n t

Priority has been given to revise the current national guidelines on clinical and related wastes in 1993-1994. It is expected that the revision will include elements such as audit, segregation and minimisation, disposal methods and new technologies.

Disposal of sewage sludge to the ocean is no longer accepted by the Australian community. The challenge for sewage sludge management is to improve sludge quality so that sludge is recognised and used as a valuable resource if properly treated. Draft national guidelines are being prepared in conjunction with the

Agricultural Resource Management Council of Australia and New Zealand and the Australian and New Zealand Environment Council.

272

APPENDIX XVI — A cronym s u sed in this re p o rt

AHEC A ustralian Health Ethics Committee

AHMAC Australian Health Ministers' Advisory Council

AHTAC A ustralian H ealth Technology Advisory Committee

HCC H ealth Care Committee

IEC Institutional Ethics Committee

MRC Medical Research Committee

NHMRC National Health and Medical Research Council

PHC Public Health Committee

PHRDC Public Health and Research Development Committee

QHC Standing Committee on Quality of Health Care

273